An Unusual Case of Acute-on-Chronic Liver Failure Leading to Liver Transplantation: Case Report

We report a case of acute-on-chronic liver failure manifesting as fulminant hepatitis caused by acute infection with hepatitis C virus in a patient with chronic cirrhosis secondary to former alcohol use. As a treatable cause with readily accessible testing, acute infection should be considered as a...

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Main Authors: Brianna Coogle, Stephen Waller, Stephanie Wood, Joshua Smith, Ryan M. Taylor
Format: Article
Language:English
Published: American College of Physicians 2024-07-01
Series:Annals of Internal Medicine: Clinical Cases
Online Access:https://www.acpjournals.org/doi/10.7326/aimcc.2023.1338
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author Brianna Coogle
Stephen Waller
Stephanie Wood
Joshua Smith
Ryan M. Taylor
author_facet Brianna Coogle
Stephen Waller
Stephanie Wood
Joshua Smith
Ryan M. Taylor
author_sort Brianna Coogle
collection DOAJ
description We report a case of acute-on-chronic liver failure manifesting as fulminant hepatitis caused by acute infection with hepatitis C virus in a patient with chronic cirrhosis secondary to former alcohol use. As a treatable cause with readily accessible testing, acute infection should be considered as a possible cause in all cases of acute-on-chronic liver failure. Hepatitis C virus viral load testing should be the test of choice to avoid missing a diagnosis in the window period of acute infection.
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publisher American College of Physicians
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series Annals of Internal Medicine: Clinical Cases
spelling doaj-art-a5df91fdb85c41e49d074637aaf74d8b2025-08-20T03:18:46ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642024-07-013710.7326/aimcc.2023.1338An Unusual Case of Acute-on-Chronic Liver Failure Leading to Liver Transplantation: Case ReportBrianna Coogle0Stephen Waller1Stephanie Wood2Joshua Smith3Ryan M. Taylor41Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas2Department of Internal Medicine, Division of Infectious Diseases, University of Kansas Medical Center, Kansas City, Kansas3Awanui Labs, Wellington Regional Hospital, Wellington, New Zealand4Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas5Department of Internal Medicine, Division of Gastroenterology, University of Kansas Medical Center, Kansas City, KansasWe report a case of acute-on-chronic liver failure manifesting as fulminant hepatitis caused by acute infection with hepatitis C virus in a patient with chronic cirrhosis secondary to former alcohol use. As a treatable cause with readily accessible testing, acute infection should be considered as a possible cause in all cases of acute-on-chronic liver failure. Hepatitis C virus viral load testing should be the test of choice to avoid missing a diagnosis in the window period of acute infection.https://www.acpjournals.org/doi/10.7326/aimcc.2023.1338
spellingShingle Brianna Coogle
Stephen Waller
Stephanie Wood
Joshua Smith
Ryan M. Taylor
An Unusual Case of Acute-on-Chronic Liver Failure Leading to Liver Transplantation: Case Report
Annals of Internal Medicine: Clinical Cases
title An Unusual Case of Acute-on-Chronic Liver Failure Leading to Liver Transplantation: Case Report
title_full An Unusual Case of Acute-on-Chronic Liver Failure Leading to Liver Transplantation: Case Report
title_fullStr An Unusual Case of Acute-on-Chronic Liver Failure Leading to Liver Transplantation: Case Report
title_full_unstemmed An Unusual Case of Acute-on-Chronic Liver Failure Leading to Liver Transplantation: Case Report
title_short An Unusual Case of Acute-on-Chronic Liver Failure Leading to Liver Transplantation: Case Report
title_sort unusual case of acute on chronic liver failure leading to liver transplantation case report
url https://www.acpjournals.org/doi/10.7326/aimcc.2023.1338
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