Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Promotes Delayed Wound Healing in Diabetic Rats
In this paper, we established a delayed wound healing model on diabetic rat to mimic the pathophysiology of clinical patients who suffered from diabetic foot ulcers. We also evaluated if transplantation of allogeneic bone marrow-derived mesenchymal stem cells could promote the delayed wound healing...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2013/647107 |
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| _version_ | 1850169094283722752 |
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| author | Jiangbo Wan Liulu Xia Wenjia Liang Yi Liu Qian Cai |
| author_facet | Jiangbo Wan Liulu Xia Wenjia Liang Yi Liu Qian Cai |
| author_sort | Jiangbo Wan |
| collection | DOAJ |
| description | In this paper, we established a delayed wound healing model on diabetic rat to mimic the pathophysiology of clinical patients who suffered from diabetic foot ulcers. We also evaluated if transplantation of allogeneic bone marrow-derived mesenchymal stem cells could promote the delayed wound healing and investigated the possible underlying biological mechanisms and stem cell behavior involved in this process. The results showed that bone marrow-derived mesenchymal stem cells had a positive effect on delayed wound healing in diabetic rats. Intramuscular transplantation demonstrated the best efficacy. This effect is associated with granulation tissue formation, angiogenesis, cellular proliferation, and high vascular endothelial growth factor expression in wound tissues. In addition, bone marrow-derived mesenchymal stem cells have been shown to mobilize and find home for ischemic and wounded tissues to participate in the process of wound healing. Intramuscular transplantation of exogenous isogeneic stem cells may be suitable for clinical application in the treatment of diabetic foot ulcers although the safety of this therapy should be considered. |
| format | Article |
| id | doaj-art-a5daf818ccd2495a92a4e8161a180fff |
| institution | OA Journals |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-a5daf818ccd2495a92a4e8161a180fff2025-08-20T02:20:49ZengWileyJournal of Diabetes Research2314-67452314-67532013-01-01201310.1155/2013/647107647107Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Promotes Delayed Wound Healing in Diabetic RatsJiangbo Wan0Liulu Xia1Wenjia Liang2Yi Liu3Qian Cai4Department of Burns and Plastic Surgery, Lanzhou General Hospital of Lanzhou Command, 333 Binhe Road, Lanzhou, Gansu 730050, ChinaDepartment of Emergency, Baoji Central Hospital, Shaanxi 721008, ChinaDepartment of Burns and Plastic Surgery, Lanzhou General Hospital of Lanzhou Command, 333 Binhe Road, Lanzhou, Gansu 730050, ChinaDepartment of Burns and Plastic Surgery, Lanzhou General Hospital of Lanzhou Command, 333 Binhe Road, Lanzhou, Gansu 730050, ChinaDepartment of Burns and Plastic Surgery, Lanzhou General Hospital of Lanzhou Command, 333 Binhe Road, Lanzhou, Gansu 730050, ChinaIn this paper, we established a delayed wound healing model on diabetic rat to mimic the pathophysiology of clinical patients who suffered from diabetic foot ulcers. We also evaluated if transplantation of allogeneic bone marrow-derived mesenchymal stem cells could promote the delayed wound healing and investigated the possible underlying biological mechanisms and stem cell behavior involved in this process. The results showed that bone marrow-derived mesenchymal stem cells had a positive effect on delayed wound healing in diabetic rats. Intramuscular transplantation demonstrated the best efficacy. This effect is associated with granulation tissue formation, angiogenesis, cellular proliferation, and high vascular endothelial growth factor expression in wound tissues. In addition, bone marrow-derived mesenchymal stem cells have been shown to mobilize and find home for ischemic and wounded tissues to participate in the process of wound healing. Intramuscular transplantation of exogenous isogeneic stem cells may be suitable for clinical application in the treatment of diabetic foot ulcers although the safety of this therapy should be considered.http://dx.doi.org/10.1155/2013/647107 |
| spellingShingle | Jiangbo Wan Liulu Xia Wenjia Liang Yi Liu Qian Cai Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Promotes Delayed Wound Healing in Diabetic Rats Journal of Diabetes Research |
| title | Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Promotes Delayed Wound Healing in Diabetic Rats |
| title_full | Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Promotes Delayed Wound Healing in Diabetic Rats |
| title_fullStr | Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Promotes Delayed Wound Healing in Diabetic Rats |
| title_full_unstemmed | Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Promotes Delayed Wound Healing in Diabetic Rats |
| title_short | Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Promotes Delayed Wound Healing in Diabetic Rats |
| title_sort | transplantation of bone marrow derived mesenchymal stem cells promotes delayed wound healing in diabetic rats |
| url | http://dx.doi.org/10.1155/2013/647107 |
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