Population pharmacokinetics analysis in Lixoft Monolix softwares
The article has discussed a step-by-step algorithm for developing population pharmacokinetics models in the Lixoft Monolix software. Features of population pharmacokinetics study’s methodology have described. Special attention is paid to the advantages of the compartmental approach and nonlinear mix...
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| Format: | Article |
| Language: | Russian |
| Published: |
LLC “Publisher OKI”
2022-02-01
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| Series: | Фармакокинетика и Фармакодинамика |
| Subjects: | |
| Online Access: | https://www.pharmacokinetica.ru/jour/article/view/292 |
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| _version_ | 1849345367650336768 |
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| author | A. I. Platova |
| author_facet | A. I. Platova |
| author_sort | A. I. Platova |
| collection | DOAJ |
| description | The article has discussed a step-by-step algorithm for developing population pharmacokinetics models in the Lixoft Monolix software. Features of population pharmacokinetics study’s methodology have described. Special attention is paid to the advantages of the compartmental approach and nonlinear mixed effects modeling in study of pharmacokinetics. Methods for estimating population pharmacokinetic parameters and its implementation in software are described. |
| format | Article |
| id | doaj-art-a5d243dc6b3d4131892fe308b9449858 |
| institution | Kabale University |
| issn | 2587-7836 2686-8830 |
| language | Russian |
| publishDate | 2022-02-01 |
| publisher | LLC “Publisher OKI” |
| record_format | Article |
| series | Фармакокинетика и Фармакодинамика |
| spelling | doaj-art-a5d243dc6b3d4131892fe308b94498582025-08-20T03:42:30ZrusLLC “Publisher OKI”Фармакокинетика и Фармакодинамика2587-78362686-88302022-02-0103365110.37489/2587-7836-2021-3-36-51281Population pharmacokinetics analysis in Lixoft Monolix softwaresA. I. Platova0The Mental Health Research Center (MHRC)The article has discussed a step-by-step algorithm for developing population pharmacokinetics models in the Lixoft Monolix software. Features of population pharmacokinetics study’s methodology have described. Special attention is paid to the advantages of the compartmental approach and nonlinear mixed effects modeling in study of pharmacokinetics. Methods for estimating population pharmacokinetic parameters and its implementation in software are described.https://www.pharmacokinetica.ru/jour/article/view/292monolixnlmemsaemmcmcbayesian functionalmlepkppk |
| spellingShingle | A. I. Platova Population pharmacokinetics analysis in Lixoft Monolix softwares Фармакокинетика и Фармакодинамика monolix nlmem saem mcmc bayesian functional mle pk ppk |
| title | Population pharmacokinetics analysis in Lixoft Monolix softwares |
| title_full | Population pharmacokinetics analysis in Lixoft Monolix softwares |
| title_fullStr | Population pharmacokinetics analysis in Lixoft Monolix softwares |
| title_full_unstemmed | Population pharmacokinetics analysis in Lixoft Monolix softwares |
| title_short | Population pharmacokinetics analysis in Lixoft Monolix softwares |
| title_sort | population pharmacokinetics analysis in lixoft monolix softwares |
| topic | monolix nlmem saem mcmc bayesian functional mle pk ppk |
| url | https://www.pharmacokinetica.ru/jour/article/view/292 |
| work_keys_str_mv | AT aiplatova populationpharmacokineticsanalysisinlixoftmonolixsoftwares |