Neurotrophin-3 as a mediator in the link between PM2.5 exposure and psychiatric disorders: A Mendelian randomization study
Background: The causal relationship between PM2.5 (particulate matter with an aerodynamic diameter ≤2.5 μm) and common mental disorders, along with its neuropathological mechanisms, remains unclear. Methods: We used genome-wide association study datasets from the UK Biobank and Psychiatric Genomics...
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Elsevier
2025-01-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324017342 |
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| author | Yuan Zhang Wei Wang Xuening Zhang Ran Jing Xin Wen Peng Xiao Xinjie Liu Zengle Zhao Tongmin Chang Yufei Li Wen Liu Chenxi Sun Xiaorong Yang Lejin Yang Ming Lu |
| author_facet | Yuan Zhang Wei Wang Xuening Zhang Ran Jing Xin Wen Peng Xiao Xinjie Liu Zengle Zhao Tongmin Chang Yufei Li Wen Liu Chenxi Sun Xiaorong Yang Lejin Yang Ming Lu |
| author_sort | Yuan Zhang |
| collection | DOAJ |
| description | Background: The causal relationship between PM2.5 (particulate matter with an aerodynamic diameter ≤2.5 μm) and common mental disorders, along with its neuropathological mechanisms, remains unclear. Methods: We used genome-wide association study datasets from the UK Biobank and Psychiatric Genomics Consortium to systematically investigate the causal relationship between PM2.5 and nine common psychiatric disorders using two-sample Mendelian randomization (TSMR) methods. Subsequently, we used two-step MR to investigate the mediating effect of 108 potential mediators in the association between PM2.5 and mental disorders. Results: Our findings indicated that PM2.5 was positively associated with major depressive disorder (odds ratio (OR): 1.33, 95 % confidence interval (CI): 1.11–1.55), anxiety disorder (OR: 2.96, 95 % CI: 2.13–3.79), schizophrenia (OR: 1.55, 95 % CI: 1.29–1.81), and attention deficit hyperactivity disorder (ADHD) (OR: 1.95, 95 % CI: 1.66–2.24). Unexpectedly, PM2.5 was inversely associated with bipolar disorder (OR: 0.65, 95 % CI: 0.37–0.93). Additionally, PM2.5 was not significantly associated with autism spectrum disorders (OR: 1.24, 95 % CI: 0.83–1.65), post-traumatic stress disorder (OR: 1.51, 95 % CI: 1.11–1.91), obsessive-compulsive disorder (OR: 0.81, 95 % CI: −0.07–1.69), or anorexia nervosa (OR: 1.42, 95 % CI: 0.86–1.98). Further analysis using two-step MR revealed that Neurotrophin-3 mediated 9.86 % of the PM2.5-ADHD association and 5.88 % of the PM2.5-schizophrenia association. Sensitivity analyses supported these findings. Conclusions: This TSMR analysis provides a comprehensive examination of the causal relationship between PM2.5 exposure and nine common psychiatric disorders, with mediation analysis offering insight into the underlying mechanisms. This study aims to raise public awareness of how air quality affects mental health through empirical evidence. |
| format | Article |
| id | doaj-art-a5cd1328d9cd445b8d89cfc5770e2e4a |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-a5cd1328d9cd445b8d89cfc5770e2e4a2025-01-23T05:26:00ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01289117658Neurotrophin-3 as a mediator in the link between PM2.5 exposure and psychiatric disorders: A Mendelian randomization studyYuan Zhang0Wei Wang1Xuening Zhang2Ran Jing3Xin Wen4Peng Xiao5Xinjie Liu6Zengle Zhao7Tongmin Chang8Yufei Li9Wen Liu10Chenxi Sun11Xiaorong Yang12Lejin Yang13Ming Lu14School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Psychology, Qilu Hospital of Shandong University, Jinan, ChinaSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, ChinaPsychology department, Mount Holyoke College, South Hadley, MA, USANHC Key Laboratory of Otorhinolaryngology, Qilu hospital and School of Basic Medical Sciences, Shandong University, Jinan, China; Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo college of Medicine, Shandong University, Jinan, ChinaKey Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo college of Medicine, Shandong University, Jinan, ChinaSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, ChinaSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, ChinaSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, ChinaSchool of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, ChinaThe First Clinical School of Medicine, Cheeloo College of Medicine, Shandong University, Jinan, ChinaDepartment of Anatomy and Neurobiology, Research Center for Sectional and Imaging Anatomy, Shandong Key Laboratory of Mental Disorders, Shandong Key Laboratory of Digital Human and Clinical Anatomy, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, ChinaClinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, China; Clinical Research Center of Shandong University, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China; Corresponding authors at: Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, China.Department of Psychology, Qilu Hospital of Shandong University, Jinan, China; Corresponding author.School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China; Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, China; Clinical Research Center of Shandong University, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China; Corresponding authors at: Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, China.Background: The causal relationship between PM2.5 (particulate matter with an aerodynamic diameter ≤2.5 μm) and common mental disorders, along with its neuropathological mechanisms, remains unclear. Methods: We used genome-wide association study datasets from the UK Biobank and Psychiatric Genomics Consortium to systematically investigate the causal relationship between PM2.5 and nine common psychiatric disorders using two-sample Mendelian randomization (TSMR) methods. Subsequently, we used two-step MR to investigate the mediating effect of 108 potential mediators in the association between PM2.5 and mental disorders. Results: Our findings indicated that PM2.5 was positively associated with major depressive disorder (odds ratio (OR): 1.33, 95 % confidence interval (CI): 1.11–1.55), anxiety disorder (OR: 2.96, 95 % CI: 2.13–3.79), schizophrenia (OR: 1.55, 95 % CI: 1.29–1.81), and attention deficit hyperactivity disorder (ADHD) (OR: 1.95, 95 % CI: 1.66–2.24). Unexpectedly, PM2.5 was inversely associated with bipolar disorder (OR: 0.65, 95 % CI: 0.37–0.93). Additionally, PM2.5 was not significantly associated with autism spectrum disorders (OR: 1.24, 95 % CI: 0.83–1.65), post-traumatic stress disorder (OR: 1.51, 95 % CI: 1.11–1.91), obsessive-compulsive disorder (OR: 0.81, 95 % CI: −0.07–1.69), or anorexia nervosa (OR: 1.42, 95 % CI: 0.86–1.98). Further analysis using two-step MR revealed that Neurotrophin-3 mediated 9.86 % of the PM2.5-ADHD association and 5.88 % of the PM2.5-schizophrenia association. Sensitivity analyses supported these findings. Conclusions: This TSMR analysis provides a comprehensive examination of the causal relationship between PM2.5 exposure and nine common psychiatric disorders, with mediation analysis offering insight into the underlying mechanisms. This study aims to raise public awareness of how air quality affects mental health through empirical evidence.http://www.sciencedirect.com/science/article/pii/S0147651324017342Mendelian randomizationPM2.5Mental disordersMajor depressive disorderAnxiety disorderSchizophrenia |
| spellingShingle | Yuan Zhang Wei Wang Xuening Zhang Ran Jing Xin Wen Peng Xiao Xinjie Liu Zengle Zhao Tongmin Chang Yufei Li Wen Liu Chenxi Sun Xiaorong Yang Lejin Yang Ming Lu Neurotrophin-3 as a mediator in the link between PM2.5 exposure and psychiatric disorders: A Mendelian randomization study Ecotoxicology and Environmental Safety Mendelian randomization PM2.5 Mental disorders Major depressive disorder Anxiety disorder Schizophrenia |
| title | Neurotrophin-3 as a mediator in the link between PM2.5 exposure and psychiatric disorders: A Mendelian randomization study |
| title_full | Neurotrophin-3 as a mediator in the link between PM2.5 exposure and psychiatric disorders: A Mendelian randomization study |
| title_fullStr | Neurotrophin-3 as a mediator in the link between PM2.5 exposure and psychiatric disorders: A Mendelian randomization study |
| title_full_unstemmed | Neurotrophin-3 as a mediator in the link between PM2.5 exposure and psychiatric disorders: A Mendelian randomization study |
| title_short | Neurotrophin-3 as a mediator in the link between PM2.5 exposure and psychiatric disorders: A Mendelian randomization study |
| title_sort | neurotrophin 3 as a mediator in the link between pm2 5 exposure and psychiatric disorders a mendelian randomization study |
| topic | Mendelian randomization PM2.5 Mental disorders Major depressive disorder Anxiety disorder Schizophrenia |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324017342 |
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