Factors influencing serum concentrations of soluble interleukin-2 receptor: a general adult population study
Introduction: Measuring soluble interleukin-2 receptor (sIL-2R) might be useful for diagnosis and monitoring of immune-mediated diseases. The study investigated factors associated with serum sIL-2R concentrations in adults. Methods: Serum sIL-2R concentrations were measured in 1499 randomly selected...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Online Access: | http://dx.doi.org/10.1080/26895293.2023.2169958 |
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| author | Vanessa Alende-Castro Manuela Alonso-Sampedro Carmen Fernández-Merino Bernardo Sopeña Carmen Vidal Francisco Gude Arturo Gonzalez-Quintela |
| author_facet | Vanessa Alende-Castro Manuela Alonso-Sampedro Carmen Fernández-Merino Bernardo Sopeña Carmen Vidal Francisco Gude Arturo Gonzalez-Quintela |
| author_sort | Vanessa Alende-Castro |
| collection | DOAJ |
| description | Introduction: Measuring soluble interleukin-2 receptor (sIL-2R) might be useful for diagnosis and monitoring of immune-mediated diseases. The study investigated factors associated with serum sIL-2R concentrations in adults. Methods: Serum sIL-2R concentrations were measured in 1499 randomly selected individuals (44.6% male, median age 52 years, range 18–91 years). Lifestyle factors (alcohol consumption, smoking, and physical activity) were assessed by questionnaire. Body mass index and data defining metabolic syndrome were measured in all participants. Atopy was defined by skin tests to aeroallergens. Results: Serum sIL-2R concentrations displayed wide variation (2.5–97.5 percentile range, 209–950 U/mL). A total of 230 (15.3%) individuals showed values higher than the standard reference range (158–623 U/mL). After adjusting for covariates, sIL-2R concentrations increased with age, particularly after 65 years. Serum sIL-2R concentrations were higher in males than in females, were higher in smokers than in never smokers, and were higher in atopic than in non-atopic individuals. Serum sIL-2R concentrations were positively associated with metabolic syndrome, particularly with abdominal obesity, and with a history of ischemic heart disease. Light alcohol drinkers showed lower sIL-2R concentrations than abstainers. Conclusion: Aging, sex, lifestyle factors, atopy, metabolic abnormalities, and ischemic heart disease might influence serum sIL-2R concentrations in adults. |
| format | Article |
| id | doaj-art-a5cce52c163b4eb4b7b313bf631448ff |
| institution | Kabale University |
| issn | 2689-5307 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | All Life |
| spelling | doaj-art-a5cce52c163b4eb4b7b313bf631448ff2024-11-15T10:36:01ZengTaylor & Francis GroupAll Life2689-53072023-12-01160110.1080/26895293.2023.21699582169958Factors influencing serum concentrations of soluble interleukin-2 receptor: a general adult population studyVanessa Alende-Castro0Manuela Alonso-Sampedro1Carmen Fernández-Merino2Bernardo Sopeña3Carmen Vidal4Francisco Gude5Arturo Gonzalez-Quintela6Complejo Hospitalario Universitario, University of Santiago de CompostelaComplejo Hospitalario Universitario, Santiago de CompostelaA EstradaComplejo Hospitalario Universitario, University of Santiago de CompostelaComplejo Hospitalario Universitario, Santiago de CompostelaComplejo Hospitalario Universitario, Santiago de CompostelaComplejo Hospitalario Universitario, University of Santiago de CompostelaIntroduction: Measuring soluble interleukin-2 receptor (sIL-2R) might be useful for diagnosis and monitoring of immune-mediated diseases. The study investigated factors associated with serum sIL-2R concentrations in adults. Methods: Serum sIL-2R concentrations were measured in 1499 randomly selected individuals (44.6% male, median age 52 years, range 18–91 years). Lifestyle factors (alcohol consumption, smoking, and physical activity) were assessed by questionnaire. Body mass index and data defining metabolic syndrome were measured in all participants. Atopy was defined by skin tests to aeroallergens. Results: Serum sIL-2R concentrations displayed wide variation (2.5–97.5 percentile range, 209–950 U/mL). A total of 230 (15.3%) individuals showed values higher than the standard reference range (158–623 U/mL). After adjusting for covariates, sIL-2R concentrations increased with age, particularly after 65 years. Serum sIL-2R concentrations were higher in males than in females, were higher in smokers than in never smokers, and were higher in atopic than in non-atopic individuals. Serum sIL-2R concentrations were positively associated with metabolic syndrome, particularly with abdominal obesity, and with a history of ischemic heart disease. Light alcohol drinkers showed lower sIL-2R concentrations than abstainers. Conclusion: Aging, sex, lifestyle factors, atopy, metabolic abnormalities, and ischemic heart disease might influence serum sIL-2R concentrations in adults.http://dx.doi.org/10.1080/26895293.2023.2169958interleukin-2 receptoragealcoholsmokingmetabolic syndromeatopy |
| spellingShingle | Vanessa Alende-Castro Manuela Alonso-Sampedro Carmen Fernández-Merino Bernardo Sopeña Carmen Vidal Francisco Gude Arturo Gonzalez-Quintela Factors influencing serum concentrations of soluble interleukin-2 receptor: a general adult population study All Life interleukin-2 receptor age alcohol smoking metabolic syndrome atopy |
| title | Factors influencing serum concentrations of soluble interleukin-2 receptor: a general adult population study |
| title_full | Factors influencing serum concentrations of soluble interleukin-2 receptor: a general adult population study |
| title_fullStr | Factors influencing serum concentrations of soluble interleukin-2 receptor: a general adult population study |
| title_full_unstemmed | Factors influencing serum concentrations of soluble interleukin-2 receptor: a general adult population study |
| title_short | Factors influencing serum concentrations of soluble interleukin-2 receptor: a general adult population study |
| title_sort | factors influencing serum concentrations of soluble interleukin 2 receptor a general adult population study |
| topic | interleukin-2 receptor age alcohol smoking metabolic syndrome atopy |
| url | http://dx.doi.org/10.1080/26895293.2023.2169958 |
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