Tumor-to-tumor metastasis: an extremely rare combination with renal cell carcinoma as the donor and a pancreatic neuroendocrine tumor as the recipient
Abstract Background Tumor-to-tumor metastasis is a rare phenomenon in which primary tumor cells metastasize hematogenously into another tumor. Herein, we report an extremely rare case of a renal cell carcinoma metastasis into a pancreatic neuroendocrine tumor exhibiting a tumor-to-tumor metastasis....
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Japan Surgical Society
2022-01-01
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| Series: | Surgical Case Reports |
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| Online Access: | https://doi.org/10.1186/s40792-022-01361-5 |
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| author | Shunryo Minezaki Takeyuki Misawa Hiroyuki Tsukayama Makoto Shibuya Keita Wada Keiji Sano Makoto Mochizuki Yuko Sasajima Hiroshi Kondo |
| author_facet | Shunryo Minezaki Takeyuki Misawa Hiroyuki Tsukayama Makoto Shibuya Keita Wada Keiji Sano Makoto Mochizuki Yuko Sasajima Hiroshi Kondo |
| author_sort | Shunryo Minezaki |
| collection | DOAJ |
| description | Abstract Background Tumor-to-tumor metastasis is a rare phenomenon in which primary tumor cells metastasize hematogenously into another tumor. Herein, we report an extremely rare case of a renal cell carcinoma metastasis into a pancreatic neuroendocrine tumor exhibiting a tumor-to-tumor metastasis. Ours is the third reported case worldwide. Case presentation The patient, a 72-year-old male, was referred to our hospital for further examination and treatment due to high levels of prostate-specific antigen. A left renal tumor and pancreatic head tumor were revealed incidentally on screening computed tomography. There were suspected to be a renal cell carcinoma and primary pancreatic neuroendocrine tumor or pancreatic metastasis from the renal cell carcinoma according to preoperative examination. The left nephrectomy and subtotal stomach-preserving pancreaticoduodenectomy were performed because of the pancreatic tumor indicated for operation in either case of diagnosis. Postoperative pathological examination showed a diagnosis of clear cell renal cell carcinoma for the left renal tumor. The pancreatic tumor was diagnosed with clear cell renal cell carcinoma metastasis into the pancreatic neuroendocrine tumor, that is to say tumor-to-tumor metastasis. Conclusion In some cases, conservative approach is selected for pancreatic neuroendocrine tumor patients who meet some requirements. However, if such patients exhibit tumor-to-tumor metastasis which combines with renal cell carcinoma and pancreatic neuroendocrine tumor as this case, conservative approach leads to progression of renal cell carcinoma. Therefore, conceiving the possibility of tumor-to-tumor metastasis, it is necessary to carefully choose a treatment plan for pancreatic neuroendocrine tumor patients associated with renal cell carcinoma, not easily choosing conservative approach. |
| format | Article |
| id | doaj-art-a5ca432bc580443ca613b1e18ded1b6b |
| institution | Kabale University |
| issn | 2198-7793 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-a5ca432bc580443ca613b1e18ded1b6b2025-08-20T03:56:58ZengJapan Surgical SocietySurgical Case Reports2198-77932022-01-01811610.1186/s40792-022-01361-5Tumor-to-tumor metastasis: an extremely rare combination with renal cell carcinoma as the donor and a pancreatic neuroendocrine tumor as the recipientShunryo Minezaki0Takeyuki Misawa1Hiroyuki Tsukayama2Makoto Shibuya3Keita Wada4Keiji Sano5Makoto Mochizuki6Yuko Sasajima7Hiroshi Kondo8Department of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineDepartment of Surgery, Teikyo University School of MedicineDepartment of Pathology, Teikyo University HospitalDepartment of Pathology, Teikyo University HospitalDepartment of Radiology, Teikyo University School of MedicineAbstract Background Tumor-to-tumor metastasis is a rare phenomenon in which primary tumor cells metastasize hematogenously into another tumor. Herein, we report an extremely rare case of a renal cell carcinoma metastasis into a pancreatic neuroendocrine tumor exhibiting a tumor-to-tumor metastasis. Ours is the third reported case worldwide. Case presentation The patient, a 72-year-old male, was referred to our hospital for further examination and treatment due to high levels of prostate-specific antigen. A left renal tumor and pancreatic head tumor were revealed incidentally on screening computed tomography. There were suspected to be a renal cell carcinoma and primary pancreatic neuroendocrine tumor or pancreatic metastasis from the renal cell carcinoma according to preoperative examination. The left nephrectomy and subtotal stomach-preserving pancreaticoduodenectomy were performed because of the pancreatic tumor indicated for operation in either case of diagnosis. Postoperative pathological examination showed a diagnosis of clear cell renal cell carcinoma for the left renal tumor. The pancreatic tumor was diagnosed with clear cell renal cell carcinoma metastasis into the pancreatic neuroendocrine tumor, that is to say tumor-to-tumor metastasis. Conclusion In some cases, conservative approach is selected for pancreatic neuroendocrine tumor patients who meet some requirements. However, if such patients exhibit tumor-to-tumor metastasis which combines with renal cell carcinoma and pancreatic neuroendocrine tumor as this case, conservative approach leads to progression of renal cell carcinoma. Therefore, conceiving the possibility of tumor-to-tumor metastasis, it is necessary to carefully choose a treatment plan for pancreatic neuroendocrine tumor patients associated with renal cell carcinoma, not easily choosing conservative approach.https://doi.org/10.1186/s40792-022-01361-5Clear cell renal cell carcinomaPancreatic neuroendocrine tumorTumor-to-tumor metastasis |
| spellingShingle | Shunryo Minezaki Takeyuki Misawa Hiroyuki Tsukayama Makoto Shibuya Keita Wada Keiji Sano Makoto Mochizuki Yuko Sasajima Hiroshi Kondo Tumor-to-tumor metastasis: an extremely rare combination with renal cell carcinoma as the donor and a pancreatic neuroendocrine tumor as the recipient Surgical Case Reports Clear cell renal cell carcinoma Pancreatic neuroendocrine tumor Tumor-to-tumor metastasis |
| title | Tumor-to-tumor metastasis: an extremely rare combination with renal cell carcinoma as the donor and a pancreatic neuroendocrine tumor as the recipient |
| title_full | Tumor-to-tumor metastasis: an extremely rare combination with renal cell carcinoma as the donor and a pancreatic neuroendocrine tumor as the recipient |
| title_fullStr | Tumor-to-tumor metastasis: an extremely rare combination with renal cell carcinoma as the donor and a pancreatic neuroendocrine tumor as the recipient |
| title_full_unstemmed | Tumor-to-tumor metastasis: an extremely rare combination with renal cell carcinoma as the donor and a pancreatic neuroendocrine tumor as the recipient |
| title_short | Tumor-to-tumor metastasis: an extremely rare combination with renal cell carcinoma as the donor and a pancreatic neuroendocrine tumor as the recipient |
| title_sort | tumor to tumor metastasis an extremely rare combination with renal cell carcinoma as the donor and a pancreatic neuroendocrine tumor as the recipient |
| topic | Clear cell renal cell carcinoma Pancreatic neuroendocrine tumor Tumor-to-tumor metastasis |
| url | https://doi.org/10.1186/s40792-022-01361-5 |
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