Familial adenomatosis coli: surgical treatment with cellular transplantation
Aim of investigation. To develop reconstructed mucosa of the rectum for improvement results of surgical treatment of familial adenomatosis polyposis coli (FAP).Material and methods. Overall 27 patients with FAP underwent surgical treatment including colectomy, demucosation of rectum and allogenic tr...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Gastro LLC
2012-11-01
|
| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| Subjects: | |
| Online Access: | https://www.gastro-j.ru/jour/article/view/1337 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823860218162839552 |
|---|---|
| author | Yu. A. Shelygin A. M. Kuzminov D. V. Vyshegorodtsev L. L. Kapuller G. T. Sukhikh |
| author_facet | Yu. A. Shelygin A. M. Kuzminov D. V. Vyshegorodtsev L. L. Kapuller G. T. Sukhikh |
| author_sort | Yu. A. Shelygin |
| collection | DOAJ |
| description | Aim of investigation. To develop reconstructed mucosa of the rectum for improvement results of surgical treatment of familial adenomatosis polyposis coli (FAP).Material and methods. Overall 27 patients with FAP underwent surgical treatment including colectomy, demucosation of rectum and allogenic transplantation of fetal intestinal epithelium cells and mesenchyma of various origin to develop reconstructed mucosa. In 5 patients the ileorectal anastomosis, in 22 – small-intestinal reservoirs were created.Results. During period from 4 to 12 wks development of rectal mucosa was observed in all patients. At follow-up from 1 year to 5 years no proliferation of polyps was revealed in 26 (96,3%) patients.Conclusions. Cell transplantation can successfully be applied for development of reconstructed rectal mucosa. Keeping part of rectum after colectomy and formation of smallintestinal reservoir allows to keep natural intestinal passage with good functional results. |
| format | Article |
| id | doaj-art-a5ca32f892db4f6dbf1344a88fc69aab |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2012-11-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-a5ca32f892db4f6dbf1344a88fc69aab2025-02-10T16:14:32ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732012-11-012265358909Familial adenomatosis coli: surgical treatment with cellular transplantationYu. A. ShelyginA. M. KuzminovD. V. VyshegorodtsevL. L. KapullerG. T. SukhikhAim of investigation. To develop reconstructed mucosa of the rectum for improvement results of surgical treatment of familial adenomatosis polyposis coli (FAP).Material and methods. Overall 27 patients with FAP underwent surgical treatment including colectomy, demucosation of rectum and allogenic transplantation of fetal intestinal epithelium cells and mesenchyma of various origin to develop reconstructed mucosa. In 5 patients the ileorectal anastomosis, in 22 – small-intestinal reservoirs were created.Results. During period from 4 to 12 wks development of rectal mucosa was observed in all patients. At follow-up from 1 year to 5 years no proliferation of polyps was revealed in 26 (96,3%) patients.Conclusions. Cell transplantation can successfully be applied for development of reconstructed rectal mucosa. Keeping part of rectum after colectomy and formation of smallintestinal reservoir allows to keep natural intestinal passage with good functional results.https://www.gastro-j.ru/jour/article/view/1337familial adenomatosis polyposis colicell transplantationmesenchymaintestinal epithelium |
| spellingShingle | Yu. A. Shelygin A. M. Kuzminov D. V. Vyshegorodtsev L. L. Kapuller G. T. Sukhikh Familial adenomatosis coli: surgical treatment with cellular transplantation Российский журнал гастроэнтерологии, гепатологии, колопроктологии familial adenomatosis polyposis coli cell transplantation mesenchyma intestinal epithelium |
| title | Familial adenomatosis coli: surgical treatment with cellular transplantation |
| title_full | Familial adenomatosis coli: surgical treatment with cellular transplantation |
| title_fullStr | Familial adenomatosis coli: surgical treatment with cellular transplantation |
| title_full_unstemmed | Familial adenomatosis coli: surgical treatment with cellular transplantation |
| title_short | Familial adenomatosis coli: surgical treatment with cellular transplantation |
| title_sort | familial adenomatosis coli surgical treatment with cellular transplantation |
| topic | familial adenomatosis polyposis coli cell transplantation mesenchyma intestinal epithelium |
| url | https://www.gastro-j.ru/jour/article/view/1337 |
| work_keys_str_mv | AT yuashelygin familialadenomatosiscolisurgicaltreatmentwithcellulartransplantation AT amkuzminov familialadenomatosiscolisurgicaltreatmentwithcellulartransplantation AT dvvyshegorodtsev familialadenomatosiscolisurgicaltreatmentwithcellulartransplantation AT llkapuller familialadenomatosiscolisurgicaltreatmentwithcellulartransplantation AT gtsukhikh familialadenomatosiscolisurgicaltreatmentwithcellulartransplantation |