Heteronymous feedback from quadriceps onto soleus is influenced by limb loading and task context
Abstract Heteronymous reflexes from quadriceps can increase and/or decrease soleus activity; yet few studies have examined factors influencing reflex strength. This study examined the independent influence of limb loading, posture, and task context on heteronymous feedback from quadriceps onto soleu...
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Nature Portfolio
2025-04-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-98220-8 |
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| author | Mark A. Lyle Steven L. Wolf Cristian Cuadra |
| author_facet | Mark A. Lyle Steven L. Wolf Cristian Cuadra |
| author_sort | Mark A. Lyle |
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| description | Abstract Heteronymous reflexes from quadriceps can increase and/or decrease soleus activity; yet few studies have examined factors influencing reflex strength. This study examined the independent influence of limb loading, posture, and task context on heteronymous feedback from quadriceps onto soleus. The influence of limb loading and posture was determined by comparing femoral nerve elicited heteronymous excitation and inhibition of soleus in a semi-recumbent position with and without 50% body weight limb loading and while standing with back support (n = 16). Task context was examined by comparing heteronymous reflex magnitudes while standing with back support to maintaining an unsupported squat posture which requires tonic soleus activity to maintain the posture (n = 12). Heteronymous inhibition decreased by 20% with limb loading in both semi-recumbent and standing postures, while excitation remained unchanged suggesting that limb loading, rather than postural orientation, independently modulates heteronymous inhibition. Inhibition decreased by 50% and excitation by 90% when maintaining the squat posture compared to supported standing. The pronounced suppression of both excitation and inhibition during the squat is considered a task-appropriate reflex modulation that aids in maintaining the posture. The results of this study highlight an important modulatory influence of limb loading afferents and task context on heteronymous reflex circuits. |
| format | Article |
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| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-a5ca1b74f4014f9ba93cd88f2bf56fad2025-08-20T02:10:46ZengNature PortfolioScientific Reports2045-23222025-04-0115111010.1038/s41598-025-98220-8Heteronymous feedback from quadriceps onto soleus is influenced by limb loading and task contextMark A. Lyle0Steven L. Wolf1Cristian Cuadra2Division of Physical Therapy, Department of Rehabilitation Medicine, Center for Physical Therapy and Movement Science, Emory University School of MedicineDivision of Physical Therapy, Department of Rehabilitation Medicine, Center for Physical Therapy and Movement Science, Emory University School of MedicineDepartment of Rehabilitation Science, University at BuffaloAbstract Heteronymous reflexes from quadriceps can increase and/or decrease soleus activity; yet few studies have examined factors influencing reflex strength. This study examined the independent influence of limb loading, posture, and task context on heteronymous feedback from quadriceps onto soleus. The influence of limb loading and posture was determined by comparing femoral nerve elicited heteronymous excitation and inhibition of soleus in a semi-recumbent position with and without 50% body weight limb loading and while standing with back support (n = 16). Task context was examined by comparing heteronymous reflex magnitudes while standing with back support to maintaining an unsupported squat posture which requires tonic soleus activity to maintain the posture (n = 12). Heteronymous inhibition decreased by 20% with limb loading in both semi-recumbent and standing postures, while excitation remained unchanged suggesting that limb loading, rather than postural orientation, independently modulates heteronymous inhibition. Inhibition decreased by 50% and excitation by 90% when maintaining the squat posture compared to supported standing. The pronounced suppression of both excitation and inhibition during the squat is considered a task-appropriate reflex modulation that aids in maintaining the posture. The results of this study highlight an important modulatory influence of limb loading afferents and task context on heteronymous reflex circuits.https://doi.org/10.1038/s41598-025-98220-8Heteronymous reflexProprioceptive feedbackTask modulationLimb loadingFemoral nerve |
| spellingShingle | Mark A. Lyle Steven L. Wolf Cristian Cuadra Heteronymous feedback from quadriceps onto soleus is influenced by limb loading and task context Scientific Reports Heteronymous reflex Proprioceptive feedback Task modulation Limb loading Femoral nerve |
| title | Heteronymous feedback from quadriceps onto soleus is influenced by limb loading and task context |
| title_full | Heteronymous feedback from quadriceps onto soleus is influenced by limb loading and task context |
| title_fullStr | Heteronymous feedback from quadriceps onto soleus is influenced by limb loading and task context |
| title_full_unstemmed | Heteronymous feedback from quadriceps onto soleus is influenced by limb loading and task context |
| title_short | Heteronymous feedback from quadriceps onto soleus is influenced by limb loading and task context |
| title_sort | heteronymous feedback from quadriceps onto soleus is influenced by limb loading and task context |
| topic | Heteronymous reflex Proprioceptive feedback Task modulation Limb loading Femoral nerve |
| url | https://doi.org/10.1038/s41598-025-98220-8 |
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