Does Melanoma Begin in a Melanocyte Stem Cell?
What is the cellular origin of melanoma? What role do melanocyte stem cells (MSC) and other melanocyte precursors play in the development of melanoma? Are MSCs and other latent melanocyte precursors more susceptible to solar radiation? These and many other questions can be very effectively addressed...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | Journal of Skin Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/571087 |
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| _version_ | 1832561996711591936 |
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| author | James D. Hoerter Patrick Bradley Alexandria Casillas Danielle Chambers Brandon Weiswasser Lauren Clements Sarah Gilbert Albert Jiao |
| author_facet | James D. Hoerter Patrick Bradley Alexandria Casillas Danielle Chambers Brandon Weiswasser Lauren Clements Sarah Gilbert Albert Jiao |
| author_sort | James D. Hoerter |
| collection | DOAJ |
| description | What is the cellular origin of melanoma? What role do melanocyte stem cells (MSC) and other melanocyte precursors play in the development of melanoma? Are MSCs and other latent melanocyte precursors more susceptible to solar radiation? These and many other questions can be very effectively addressed using the zebrafish model. Zebrafish have a robust regenerative capability, permitting the study of how MSCs are regulated and recruited at specific times and places to generate the pigment pattern following fin amputation or melanocyte ablation. They can be used to determine the effects of environmental radiation on the proliferation, survival, repair, and differentiation of MSCs. Our lab is using zebrafish to investigate how UVA- (320–400 nm) and UVB- (290–320 nm) induced damage to MSCs may contribute to the development of melanoma. A review is given of MSCs in zebrafish as well as experimental techniques and drugs for manipulating MSC populations. These techniques can be used to design experiments to help answer many questions regarding the role of MSCs or melanocyte precursors in the formation of melanoma stem cells and tumors following exposure to UVA/UVB radiation. |
| format | Article |
| id | doaj-art-a5c8d14d641d4c85af0cd13d1287af60 |
| institution | Kabale University |
| issn | 2090-2905 2090-2913 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Skin Cancer |
| spelling | doaj-art-a5c8d14d641d4c85af0cd13d1287af602025-02-03T01:23:40ZengWileyJournal of Skin Cancer2090-29052090-29132012-01-01201210.1155/2012/571087571087Does Melanoma Begin in a Melanocyte Stem Cell?James D. Hoerter0Patrick Bradley1Alexandria Casillas2Danielle Chambers3Brandon Weiswasser4Lauren Clements5Sarah Gilbert6Albert Jiao7Department of Biological Sciences, Ferris State University, Big Rapids, MI 49307, USADepartment of Biological Sciences, Ferris State University, Big Rapids, MI 49307, USADepartment of Biological Sciences, Ferris State University, Big Rapids, MI 49307, USADepartment of Biological Sciences, Ferris State University, Big Rapids, MI 49307, USADepartment of Biological Sciences, Ferris State University, Big Rapids, MI 49307, USADepartment of Biological Sciences, Ferris State University, Big Rapids, MI 49307, USADepartment of Biological Sciences, Ferris State University, Big Rapids, MI 49307, USADepartment of Biological Sciences, Ferris State University, Big Rapids, MI 49307, USAWhat is the cellular origin of melanoma? What role do melanocyte stem cells (MSC) and other melanocyte precursors play in the development of melanoma? Are MSCs and other latent melanocyte precursors more susceptible to solar radiation? These and many other questions can be very effectively addressed using the zebrafish model. Zebrafish have a robust regenerative capability, permitting the study of how MSCs are regulated and recruited at specific times and places to generate the pigment pattern following fin amputation or melanocyte ablation. They can be used to determine the effects of environmental radiation on the proliferation, survival, repair, and differentiation of MSCs. Our lab is using zebrafish to investigate how UVA- (320–400 nm) and UVB- (290–320 nm) induced damage to MSCs may contribute to the development of melanoma. A review is given of MSCs in zebrafish as well as experimental techniques and drugs for manipulating MSC populations. These techniques can be used to design experiments to help answer many questions regarding the role of MSCs or melanocyte precursors in the formation of melanoma stem cells and tumors following exposure to UVA/UVB radiation.http://dx.doi.org/10.1155/2012/571087 |
| spellingShingle | James D. Hoerter Patrick Bradley Alexandria Casillas Danielle Chambers Brandon Weiswasser Lauren Clements Sarah Gilbert Albert Jiao Does Melanoma Begin in a Melanocyte Stem Cell? Journal of Skin Cancer |
| title | Does Melanoma Begin in a Melanocyte Stem Cell? |
| title_full | Does Melanoma Begin in a Melanocyte Stem Cell? |
| title_fullStr | Does Melanoma Begin in a Melanocyte Stem Cell? |
| title_full_unstemmed | Does Melanoma Begin in a Melanocyte Stem Cell? |
| title_short | Does Melanoma Begin in a Melanocyte Stem Cell? |
| title_sort | does melanoma begin in a melanocyte stem cell |
| url | http://dx.doi.org/10.1155/2012/571087 |
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