α-Amylase and α-Glucosidase Inhibitory Saponins from Polyscias fruticosa Leaves
Three bisdesmosidic saponins 3-O-[β-D-glucopyranosyl-(1→4)-β-D-glucuronopyranosyl] oleanolic acid 28-O-β-D-glucopyranosyl ester (1), polyscioside D (2), and 3-O-{β-D-glucopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)]-β-D-glucuronopyranosyl} oleanolic acid 28-O-β-D-glucopyranosyl-(1→2)-β-D-galactopyrano...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2016/2082946 |
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| author | Tran Thi Hong Hanh Nguyen Hai Dang Nguyen Tien Dat |
| author_facet | Tran Thi Hong Hanh Nguyen Hai Dang Nguyen Tien Dat |
| author_sort | Tran Thi Hong Hanh |
| collection | DOAJ |
| description | Three bisdesmosidic saponins 3-O-[β-D-glucopyranosyl-(1→4)-β-D-glucuronopyranosyl] oleanolic acid 28-O-β-D-glucopyranosyl ester (1), polyscioside D (2), and 3-O-{β-D-glucopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)]-β-D-glucuronopyranosyl} oleanolic acid 28-O-β-D-glucopyranosyl-(1→2)-β-D-galactopyranosyl ester (3) were isolated from a methanol extract of Polyscias fruticosa (L.) Harms leaves. Compound 1 was obtained as a main constituent and compound 3 was reported for the first time and named as polyscioside I. Saponin 1 inhibited porcine pancreas α-amylase and yeast α-glucosidase activities while 2 and 3 were inactive. Synergistic inhibitory effect on α-amylase was observed from the combination of low concentrations of 1 and acarbose. The findings suggest the use of P. fruticosa and its major saponin 1 for the prevention and treatment of diabetes and its complications. |
| format | Article |
| id | doaj-art-a5c49470619847dd91dd15d1e197ce86 |
| institution | Kabale University |
| issn | 2090-9063 2090-9071 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Chemistry |
| spelling | doaj-art-a5c49470619847dd91dd15d1e197ce862025-02-03T06:08:22ZengWileyJournal of Chemistry2090-90632090-90712016-01-01201610.1155/2016/20829462082946α-Amylase and α-Glucosidase Inhibitory Saponins from Polyscias fruticosa LeavesTran Thi Hong Hanh0Nguyen Hai Dang1Nguyen Tien Dat2Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi 100000, VietnamInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi 100000, VietnamInstitute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Cau Giay, Hanoi 100000, VietnamThree bisdesmosidic saponins 3-O-[β-D-glucopyranosyl-(1→4)-β-D-glucuronopyranosyl] oleanolic acid 28-O-β-D-glucopyranosyl ester (1), polyscioside D (2), and 3-O-{β-D-glucopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)]-β-D-glucuronopyranosyl} oleanolic acid 28-O-β-D-glucopyranosyl-(1→2)-β-D-galactopyranosyl ester (3) were isolated from a methanol extract of Polyscias fruticosa (L.) Harms leaves. Compound 1 was obtained as a main constituent and compound 3 was reported for the first time and named as polyscioside I. Saponin 1 inhibited porcine pancreas α-amylase and yeast α-glucosidase activities while 2 and 3 were inactive. Synergistic inhibitory effect on α-amylase was observed from the combination of low concentrations of 1 and acarbose. The findings suggest the use of P. fruticosa and its major saponin 1 for the prevention and treatment of diabetes and its complications.http://dx.doi.org/10.1155/2016/2082946 |
| spellingShingle | Tran Thi Hong Hanh Nguyen Hai Dang Nguyen Tien Dat α-Amylase and α-Glucosidase Inhibitory Saponins from Polyscias fruticosa Leaves Journal of Chemistry |
| title | α-Amylase and α-Glucosidase Inhibitory Saponins from Polyscias fruticosa Leaves |
| title_full | α-Amylase and α-Glucosidase Inhibitory Saponins from Polyscias fruticosa Leaves |
| title_fullStr | α-Amylase and α-Glucosidase Inhibitory Saponins from Polyscias fruticosa Leaves |
| title_full_unstemmed | α-Amylase and α-Glucosidase Inhibitory Saponins from Polyscias fruticosa Leaves |
| title_short | α-Amylase and α-Glucosidase Inhibitory Saponins from Polyscias fruticosa Leaves |
| title_sort | α amylase and α glucosidase inhibitory saponins from polyscias fruticosa leaves |
| url | http://dx.doi.org/10.1155/2016/2082946 |
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