Key developments and hotspots in programmed cell death in liver cancer pain: a bibliometric study
Abstract Objectives This bibliometric study aimed to elucidate key developments, influential publications, and emerging research hotspots on programmed cell death (PCD) in liver cancer–associated pain, thereby providing guidance for future mechanism-based, patient-centered therapies. Methods A compr...
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| Format: | Article |
| Language: | English |
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Springer
2025-06-01
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| Series: | Discover Oncology |
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| Online Access: | https://doi.org/10.1007/s12672-025-02759-x |
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| _version_ | 1850224227004710912 |
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| author | Yanmei Yang Yongjin He Ping Zhang Chunyan Wang |
| author_facet | Yanmei Yang Yongjin He Ping Zhang Chunyan Wang |
| author_sort | Yanmei Yang |
| collection | DOAJ |
| description | Abstract Objectives This bibliometric study aimed to elucidate key developments, influential publications, and emerging research hotspots on programmed cell death (PCD) in liver cancer–associated pain, thereby providing guidance for future mechanism-based, patient-centered therapies. Methods A comprehensive search was performed in the Web of Science using terms encompassing liver cancer, pain, and various PCD modalities. After multi-stage screening for relevance and quality, a dataset of 324 articles (2000–2024) was analyzed. Tools such as VOSviewer and Bibliometrix facilitated performance analysis, co-citation mapping, keyword clustering, and trend topic identification. Results The annual publication output increased notably after 2015, reflecting intensified interest in molecular pathways (apoptosis, ferroptosis, autophagy) and their clinical implications. China led in publication volume, while the USA and several European countries demonstrated high impact and extensive international collaborations. Keyword analysis revealed five thematic clusters, highlighting the prominence of inflammation, NF-κB signaling, oxidative stress–mediated apoptosis, combined therapeutic approaches, and metastasis-driven pain. Highly cited articles focused on flavonoids in apoptosis, immunogenic cell death, and cyclooxygenase-2 regulation, underscoring a shift toward integrative regimens that target both tumor progression and pain mechanisms. Conclusion Programmed cell death research in liver cancer pain has evolved into a rapidly expanding, multidisciplinary field. Findings point to a paradigm shift from purely cytotoxic strategies to more holistic approaches that merge immunotherapy, biomarker-driven diagnosis, and targeted interventions aimed at alleviating pain while controlling tumor growth. These insights lay the groundwork for precision-oriented, mechanism-based treatments that address the multifaceted challenges faced by patients with advanced liver cancer. |
| format | Article |
| id | doaj-art-a5bd17fc19c84eddbd6c82c3f6bd5e3e |
| institution | OA Journals |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-a5bd17fc19c84eddbd6c82c3f6bd5e3e2025-08-20T02:05:41ZengSpringerDiscover Oncology2730-60112025-06-0116111710.1007/s12672-025-02759-xKey developments and hotspots in programmed cell death in liver cancer pain: a bibliometric studyYanmei Yang0Yongjin He1Ping Zhang2Chunyan Wang3Tianjin First Central HospitalTianjin First Central HospitalTianjin First Central HospitalYunyang County People’s HospitalAbstract Objectives This bibliometric study aimed to elucidate key developments, influential publications, and emerging research hotspots on programmed cell death (PCD) in liver cancer–associated pain, thereby providing guidance for future mechanism-based, patient-centered therapies. Methods A comprehensive search was performed in the Web of Science using terms encompassing liver cancer, pain, and various PCD modalities. After multi-stage screening for relevance and quality, a dataset of 324 articles (2000–2024) was analyzed. Tools such as VOSviewer and Bibliometrix facilitated performance analysis, co-citation mapping, keyword clustering, and trend topic identification. Results The annual publication output increased notably after 2015, reflecting intensified interest in molecular pathways (apoptosis, ferroptosis, autophagy) and their clinical implications. China led in publication volume, while the USA and several European countries demonstrated high impact and extensive international collaborations. Keyword analysis revealed five thematic clusters, highlighting the prominence of inflammation, NF-κB signaling, oxidative stress–mediated apoptosis, combined therapeutic approaches, and metastasis-driven pain. Highly cited articles focused on flavonoids in apoptosis, immunogenic cell death, and cyclooxygenase-2 regulation, underscoring a shift toward integrative regimens that target both tumor progression and pain mechanisms. Conclusion Programmed cell death research in liver cancer pain has evolved into a rapidly expanding, multidisciplinary field. Findings point to a paradigm shift from purely cytotoxic strategies to more holistic approaches that merge immunotherapy, biomarker-driven diagnosis, and targeted interventions aimed at alleviating pain while controlling tumor growth. These insights lay the groundwork for precision-oriented, mechanism-based treatments that address the multifaceted challenges faced by patients with advanced liver cancer.https://doi.org/10.1007/s12672-025-02759-xProgrammed cell deathLiver cancer painApoptosisAutophagyImmunotherapy |
| spellingShingle | Yanmei Yang Yongjin He Ping Zhang Chunyan Wang Key developments and hotspots in programmed cell death in liver cancer pain: a bibliometric study Discover Oncology Programmed cell death Liver cancer pain Apoptosis Autophagy Immunotherapy |
| title | Key developments and hotspots in programmed cell death in liver cancer pain: a bibliometric study |
| title_full | Key developments and hotspots in programmed cell death in liver cancer pain: a bibliometric study |
| title_fullStr | Key developments and hotspots in programmed cell death in liver cancer pain: a bibliometric study |
| title_full_unstemmed | Key developments and hotspots in programmed cell death in liver cancer pain: a bibliometric study |
| title_short | Key developments and hotspots in programmed cell death in liver cancer pain: a bibliometric study |
| title_sort | key developments and hotspots in programmed cell death in liver cancer pain a bibliometric study |
| topic | Programmed cell death Liver cancer pain Apoptosis Autophagy Immunotherapy |
| url | https://doi.org/10.1007/s12672-025-02759-x |
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