Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy.

Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy.

Five X-linked severe combined immunodeficiency patients (SCID-X1) successfully treated with autologous bone marrow stem cells infected ex vivo with an IL2RG-containing retrovirus subsequently developed T-cell leukemia and four contained insertional mutations at LMO2. Genetic evidence also suggests a...

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Bibliographic Details
Main Authors: Utpal P Davé, Keiko Akagi, Rati Tripathi, Susan M Cleveland, Mary A Thompson, Ming Yi, Robert Stephens, James R Downing, Nancy A Jenkins, Neal G Copeland
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-05-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000491&type=printable
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