NIR light-driven transformable liquid metal-based nanovaccines restrain postoperative colorectal cancer recurrence
Cancer vaccines mount specific immune memory responses and hold great potential in suppressing postoperative colorectal cancer (CRC) recurrence. However, undesired lymph node trafficking and antigen cross-presentation hamper clinical translation of nanovaccines. Here, we propose a controllable trans...
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KeAi Communications Co., Ltd.
2025-09-01
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X25002737 |
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| author | Zheng Dai Feng Liu Miaodeng Liu Yuqi Song Hongyan Zhang Cheng Zhou Wenyu Liu Xiaoqiong Li Guobin Wang Lin Wang Zheng Wang |
| author_facet | Zheng Dai Feng Liu Miaodeng Liu Yuqi Song Hongyan Zhang Cheng Zhou Wenyu Liu Xiaoqiong Li Guobin Wang Lin Wang Zheng Wang |
| author_sort | Zheng Dai |
| collection | DOAJ |
| description | Cancer vaccines mount specific immune memory responses and hold great potential in suppressing postoperative colorectal cancer (CRC) recurrence. However, undesired lymph node trafficking and antigen cross-presentation hamper clinical translation of nanovaccines. Here, we propose a controllable transformable nanovaccine grounded on thermal fusion feature of liquid metal (LM) nanoparticles against postoperative CRC recurrence. After draining to lymph nodes, LM-based nanovaccines (LMVs) aggregate and transform from spheres to fusiform sharp under NIR irradiation, conducive to cytoplasmic delivery of LMVs and subsequent antigen cross-presentation. Benefitting from the morphology transformation, LMVs prolong the retention of loaded vaccine molecules in lymph nodes, resulting in satisfactory dendritic cell (DC) recognition and maturation. Such dual effects of transformable LMVs efficiently activate DCs and cytotoxic CD8+ T cells, mediating strong systemic immune responses against local recurrence. Moreover, the transformable LMVs can induce potent specific immune memory, which is pivotal for eradicating metachronous liver and lung metastasis. This study provides a newly NIR light-regulated postoperative CRC prevention approach. |
| format | Article |
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| institution | DOAJ |
| issn | 2452-199X |
| language | English |
| publishDate | 2025-09-01 |
| publisher | KeAi Communications Co., Ltd. |
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| series | Bioactive Materials |
| spelling | doaj-art-a5ae4ae4cd0d4435917c3e7ae61669672025-08-20T03:18:15ZengKeAi Communications Co., Ltd.Bioactive Materials2452-199X2025-09-015177478610.1016/j.bioactmat.2025.06.037NIR light-driven transformable liquid metal-based nanovaccines restrain postoperative colorectal cancer recurrenceZheng Dai0Feng Liu1Miaodeng Liu2Yuqi Song3Hongyan Zhang4Cheng Zhou5Wenyu Liu6Xiaoqiong Li7Guobin Wang8Lin Wang9Zheng Wang10Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Clinical Research Center of Minimally Invasive Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Key Laboratory of Biological Targeted Therapy, Huazhong University of Science and Technology, Ministry of Education, Wuhan, Hubei, 430022, ChinaResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Clinical Research Center of Minimally Invasive Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Key Laboratory of Biological Targeted Therapy, Huazhong University of Science and Technology, Ministry of Education, Wuhan, Hubei, 430022, China; Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, ChinaResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Clinical Research Center of Minimally Invasive Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Key Laboratory of Biological Targeted Therapy, Huazhong University of Science and Technology, Ministry of Education, Wuhan, Hubei, 430022, China; Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, ChinaDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Clinical Research Center of Minimally Invasive Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Key Laboratory of Biological Targeted Therapy, Huazhong University of Science and Technology, Ministry of Education, Wuhan, Hubei, 430022, ChinaResearch Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Clinical Research Center of Minimally Invasive Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Key Laboratory of Biological Targeted Therapy, Huazhong University of Science and Technology, Ministry of Education, Wuhan, Hubei, 430022, China; Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, ChinaDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Clinical Research Center of Minimally Invasive Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Key Laboratory of Biological Targeted Therapy, Huazhong University of Science and Technology, Ministry of Education, Wuhan, Hubei, 430022, ChinaDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Clinical Research Center of Minimally Invasive Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Key Laboratory of Biological Targeted Therapy, Huazhong University of Science and Technology, Ministry of Education, Wuhan, Hubei, 430022, ChinaDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Clinical Research Center of Minimally Invasive Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Key Laboratory of Biological Targeted Therapy, Huazhong University of Science and Technology, Ministry of Education, Wuhan, Hubei, 430022, ChinaDepartment of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Clinical Research Center of Minimally Invasive Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Corresponding author. Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Clinical Research Center of Minimally Invasive Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Key Laboratory of Biological Targeted Therapy, Huazhong University of Science and Technology, Ministry of Education, Wuhan, Hubei, 430022, China; Department of Clinical Laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Corresponding author. Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Research Center for Tissue Engineering and Regenerative Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Provincial Engineering Research Center of Clinical Laboratory and Active Health Smart Equipment, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Hubei Clinical Research Center of Minimally Invasive Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Key Laboratory of Biological Targeted Therapy, Huazhong University of Science and Technology, Ministry of Education, Wuhan, Hubei, 430022, China; Corresponding author. Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.Cancer vaccines mount specific immune memory responses and hold great potential in suppressing postoperative colorectal cancer (CRC) recurrence. However, undesired lymph node trafficking and antigen cross-presentation hamper clinical translation of nanovaccines. Here, we propose a controllable transformable nanovaccine grounded on thermal fusion feature of liquid metal (LM) nanoparticles against postoperative CRC recurrence. After draining to lymph nodes, LM-based nanovaccines (LMVs) aggregate and transform from spheres to fusiform sharp under NIR irradiation, conducive to cytoplasmic delivery of LMVs and subsequent antigen cross-presentation. Benefitting from the morphology transformation, LMVs prolong the retention of loaded vaccine molecules in lymph nodes, resulting in satisfactory dendritic cell (DC) recognition and maturation. Such dual effects of transformable LMVs efficiently activate DCs and cytotoxic CD8+ T cells, mediating strong systemic immune responses against local recurrence. Moreover, the transformable LMVs can induce potent specific immune memory, which is pivotal for eradicating metachronous liver and lung metastasis. This study provides a newly NIR light-regulated postoperative CRC prevention approach.http://www.sciencedirect.com/science/article/pii/S2452199X25002737Colorectal cancerPostoperative recurrenceLiquid metalTransformable nanovaccineImmunotherapy |
| spellingShingle | Zheng Dai Feng Liu Miaodeng Liu Yuqi Song Hongyan Zhang Cheng Zhou Wenyu Liu Xiaoqiong Li Guobin Wang Lin Wang Zheng Wang NIR light-driven transformable liquid metal-based nanovaccines restrain postoperative colorectal cancer recurrence Bioactive Materials Colorectal cancer Postoperative recurrence Liquid metal Transformable nanovaccine Immunotherapy |
| title | NIR light-driven transformable liquid metal-based nanovaccines restrain postoperative colorectal cancer recurrence |
| title_full | NIR light-driven transformable liquid metal-based nanovaccines restrain postoperative colorectal cancer recurrence |
| title_fullStr | NIR light-driven transformable liquid metal-based nanovaccines restrain postoperative colorectal cancer recurrence |
| title_full_unstemmed | NIR light-driven transformable liquid metal-based nanovaccines restrain postoperative colorectal cancer recurrence |
| title_short | NIR light-driven transformable liquid metal-based nanovaccines restrain postoperative colorectal cancer recurrence |
| title_sort | nir light driven transformable liquid metal based nanovaccines restrain postoperative colorectal cancer recurrence |
| topic | Colorectal cancer Postoperative recurrence Liquid metal Transformable nanovaccine Immunotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2452199X25002737 |
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