Isolation and Characterization of Two Coumarin Compounds from the Chloroform Fraction of <i>Scadoxus multiflorus</i> (Martyn) Raf. (Amaryllidaceae)
In this study, the aerial parts of <i>Scadoxus multiflorus</i> were extracted using methanol through a maceration process. The resulting methanol crude extract was subsequently partitioned with solvents including n-hexane, chloroform, ethyl acetate, and n-butanol. Extensive column chroma...
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2025-02-01
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| author | Olaiya Akeem Ayodele Tijani Tawakaltu Omolara Abdullahi Sakynah Musa Sule Mohammed Ibrahim |
| author_facet | Olaiya Akeem Ayodele Tijani Tawakaltu Omolara Abdullahi Sakynah Musa Sule Mohammed Ibrahim |
| author_sort | Olaiya Akeem Ayodele |
| collection | DOAJ |
| description | In this study, the aerial parts of <i>Scadoxus multiflorus</i> were extracted using methanol through a maceration process. The resulting methanol crude extract was subsequently partitioned with solvents including n-hexane, chloroform, ethyl acetate, and n-butanol. Extensive column chromatography separation of the chloroform fraction, followed by isocratic elution of two pooled fractions, led to the isolation of two coumarin derivatives: 2-methyl-2H-chromen-7-ol and 7-methoxy-2H-chromen-2-one. These compounds underwent various physicochemical analyses, such as chemical tests, melting point determination, and solubility assessments. Structural elucidation of the isolated compounds was conducted using UV spectroscopy, FT-IR, and 1D/2D NMR techniques. The final molecular structures were confirmed and named using ChemDraw. |
| format | Article |
| id | doaj-art-a5a945756c8a4aaea16b44a25b74189a |
| institution | Kabale University |
| issn | 2673-4583 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemistry Proceedings |
| spelling | doaj-art-a5a945756c8a4aaea16b44a25b74189a2025-08-20T03:27:21ZengMDPI AGChemistry Proceedings2673-45832025-02-011618910.3390/ecsoc-28-20184Isolation and Characterization of Two Coumarin Compounds from the Chloroform Fraction of <i>Scadoxus multiflorus</i> (Martyn) Raf. (Amaryllidaceae)Olaiya Akeem Ayodele0Tijani Tawakaltu Omolara1Abdullahi Sakynah Musa2Sule Mohammed Ibrahim3Department of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria 810107, NigeriaDepartment of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria 810107, NigeriaDepartment of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria 810107, NigeriaDepartment of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria 810107, NigeriaIn this study, the aerial parts of <i>Scadoxus multiflorus</i> were extracted using methanol through a maceration process. The resulting methanol crude extract was subsequently partitioned with solvents including n-hexane, chloroform, ethyl acetate, and n-butanol. Extensive column chromatography separation of the chloroform fraction, followed by isocratic elution of two pooled fractions, led to the isolation of two coumarin derivatives: 2-methyl-2H-chromen-7-ol and 7-methoxy-2H-chromen-2-one. These compounds underwent various physicochemical analyses, such as chemical tests, melting point determination, and solubility assessments. Structural elucidation of the isolated compounds was conducted using UV spectroscopy, FT-IR, and 1D/2D NMR techniques. The final molecular structures were confirmed and named using ChemDraw.https://www.mdpi.com/2673-4583/16/1/89Scadoxus multifloruscoumarinchromen |
| spellingShingle | Olaiya Akeem Ayodele Tijani Tawakaltu Omolara Abdullahi Sakynah Musa Sule Mohammed Ibrahim Isolation and Characterization of Two Coumarin Compounds from the Chloroform Fraction of <i>Scadoxus multiflorus</i> (Martyn) Raf. (Amaryllidaceae) Chemistry Proceedings Scadoxus multiflorus coumarin chromen |
| title | Isolation and Characterization of Two Coumarin Compounds from the Chloroform Fraction of <i>Scadoxus multiflorus</i> (Martyn) Raf. (Amaryllidaceae) |
| title_full | Isolation and Characterization of Two Coumarin Compounds from the Chloroform Fraction of <i>Scadoxus multiflorus</i> (Martyn) Raf. (Amaryllidaceae) |
| title_fullStr | Isolation and Characterization of Two Coumarin Compounds from the Chloroform Fraction of <i>Scadoxus multiflorus</i> (Martyn) Raf. (Amaryllidaceae) |
| title_full_unstemmed | Isolation and Characterization of Two Coumarin Compounds from the Chloroform Fraction of <i>Scadoxus multiflorus</i> (Martyn) Raf. (Amaryllidaceae) |
| title_short | Isolation and Characterization of Two Coumarin Compounds from the Chloroform Fraction of <i>Scadoxus multiflorus</i> (Martyn) Raf. (Amaryllidaceae) |
| title_sort | isolation and characterization of two coumarin compounds from the chloroform fraction of i scadoxus multiflorus i martyn raf amaryllidaceae |
| topic | Scadoxus multiflorus coumarin chromen |
| url | https://www.mdpi.com/2673-4583/16/1/89 |
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