Activation of mechanoreceptor Piezo1 inhibits enteric neuronal growth and migration in vitro

Activation of mechanoreceptor Piezo1 inhibits enteric neuronal growth and migration in vitro

IntroductionDysfunction of the enteric nervous system (ENS) is linked to a myriad of gastrointestinal (GI) disorders. Piezo1 is a mechanosensitive ion channel found throughout the GI tract, but its role in the ENS is largely unknown. We hypothesize that Piezo1 plays an important role in the growth a...

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Bibliographic Details
Main Authors:	Chioma Moneme, Oluyinka O. Olutoye, Michał F. Sobstel, Yuwen Zhang, Xinyu Zhou, Jacob L. Kaminer, Britney A. Hsu, Chengli Shen, Arabinda Mandal, Hui Li, Ling Yu, Swathi Balaji, Sundeep G. Keswani, Lily S. Cheng
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-12-01
Series:	Frontiers in Molecular Neuroscience
Subjects:	enteric nervous system (ENS) enteric neural crest-derived progenitor cells (ENPC) biomechanical force mechanotransduction neuronal cell migration neuronal regeneration
Online Access:	https://www.frontiersin.org/articles/10.3389/fnmol.2024.1474025/full
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