Aglutenic cupcakes for gastro-intestinal symptoms and hematological indices in diagnosed celiac children –A randomized trialWhat is knownWhat is new
S U M M A R Y: Fundamental adherence to gluten-free diet can improve gastrointestinal symptoms. Substitution of wheat should be done in order to fulfil gluten-free criteria and nutrient density. Objective: This study was conducted to assess the efficacy of gluten free cupcakes formulated by substitu...
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Elsevier
2025-06-01
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| Series: | Clinical Nutrition Open Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266726852500049X |
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| author | Shaista Jabeen Azmat Ullah Khan |
| author_facet | Shaista Jabeen Azmat Ullah Khan |
| author_sort | Shaista Jabeen |
| collection | DOAJ |
| description | S U M M A R Y: Fundamental adherence to gluten-free diet can improve gastrointestinal symptoms. Substitution of wheat should be done in order to fulfil gluten-free criteria and nutrient density. Objective: This study was conducted to assess the efficacy of gluten free cupcakes formulated by substitution of low FODMAP foods. Design: Random parallel assignment was adopted (1b). Methods: A 12 weeks efficacy trial was conducted on children of age 3–8 years, and were randomly allocated into two groups (n = 35 in each group). Gluten free cupcakes group was provided with gluten-free flour blend cupcakes (35 g), while placebo group was provided with rice flour-based cupcakes. Results: Weight was significantly increased in both placebo (13.7 ± 4.8 to 14.5 ± 4.4) and gluten free (13.6 ± 4.6 to 15.4 ± 4.6) groups. Mid upper arm circumference was significantly increased in gluten free group only (15.3 ± 3 to 15.5 ± 3). Abdominal pain was reduced to 38.7% from 6.5% (absent) in the placebo group compared to gluten free group 15.2%–33.3% (absent), while diarrhea was reduced to 33.3% from 27.3%. Serum platelets were significantly reduced in gluten free cupcake group (GFC) from 308.4 ± 39.5 to 300.3 ± 38.7 (P < 0.05). Tissue trans-glutaminase antibody (tTg-IgA) was significantly reduced from 148 ± 51 to 127 ± 31. Conclusion: Formulated gluten-free cupcakes are found to be effective in improving gastrointestinal symptoms and anthropometrics in patients with celiac disease. ClinicalTrials.gov PRS: Record Summary NCT06359613. |
| format | Article |
| id | doaj-art-a5a49eef25b34a4ca39e562a3aa60b66 |
| institution | DOAJ |
| issn | 2667-2685 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Nutrition Open Science |
| spelling | doaj-art-a5a49eef25b34a4ca39e562a3aa60b662025-08-20T03:07:25ZengElsevierClinical Nutrition Open Science2667-26852025-06-016130731610.1016/j.nutos.2025.04.010Aglutenic cupcakes for gastro-intestinal symptoms and hematological indices in diagnosed celiac children –A randomized trialWhat is knownWhat is newShaista Jabeen0Azmat Ullah Khan1University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, Pakistan; Department of Food Science and Human Nutrition, Faculty of Bio-Sciences, University of Veterinary and Animal Sciences, Lahore, Pakistan; Corresponding author. University Institute of Diet and Nutritional Sciences, Faculty of Allied Health Sciences, The University of Lahore, PakistanDepartment of Food Science and Human Nutrition, Faculty of Bio-Sciences, University of Veterinary and Animal Sciences, Lahore, PakistanS U M M A R Y: Fundamental adherence to gluten-free diet can improve gastrointestinal symptoms. Substitution of wheat should be done in order to fulfil gluten-free criteria and nutrient density. Objective: This study was conducted to assess the efficacy of gluten free cupcakes formulated by substitution of low FODMAP foods. Design: Random parallel assignment was adopted (1b). Methods: A 12 weeks efficacy trial was conducted on children of age 3–8 years, and were randomly allocated into two groups (n = 35 in each group). Gluten free cupcakes group was provided with gluten-free flour blend cupcakes (35 g), while placebo group was provided with rice flour-based cupcakes. Results: Weight was significantly increased in both placebo (13.7 ± 4.8 to 14.5 ± 4.4) and gluten free (13.6 ± 4.6 to 15.4 ± 4.6) groups. Mid upper arm circumference was significantly increased in gluten free group only (15.3 ± 3 to 15.5 ± 3). Abdominal pain was reduced to 38.7% from 6.5% (absent) in the placebo group compared to gluten free group 15.2%–33.3% (absent), while diarrhea was reduced to 33.3% from 27.3%. Serum platelets were significantly reduced in gluten free cupcake group (GFC) from 308.4 ± 39.5 to 300.3 ± 38.7 (P < 0.05). Tissue trans-glutaminase antibody (tTg-IgA) was significantly reduced from 148 ± 51 to 127 ± 31. Conclusion: Formulated gluten-free cupcakes are found to be effective in improving gastrointestinal symptoms and anthropometrics in patients with celiac disease. ClinicalTrials.gov PRS: Record Summary NCT06359613.http://www.sciencedirect.com/science/article/pii/S266726852500049XGluten freeCupcakesChildrenAnthropometry |
| spellingShingle | Shaista Jabeen Azmat Ullah Khan Aglutenic cupcakes for gastro-intestinal symptoms and hematological indices in diagnosed celiac children –A randomized trialWhat is knownWhat is new Clinical Nutrition Open Science Gluten free Cupcakes Children Anthropometry |
| title | Aglutenic cupcakes for gastro-intestinal symptoms and hematological indices in diagnosed celiac children –A randomized trialWhat is knownWhat is new |
| title_full | Aglutenic cupcakes for gastro-intestinal symptoms and hematological indices in diagnosed celiac children –A randomized trialWhat is knownWhat is new |
| title_fullStr | Aglutenic cupcakes for gastro-intestinal symptoms and hematological indices in diagnosed celiac children –A randomized trialWhat is knownWhat is new |
| title_full_unstemmed | Aglutenic cupcakes for gastro-intestinal symptoms and hematological indices in diagnosed celiac children –A randomized trialWhat is knownWhat is new |
| title_short | Aglutenic cupcakes for gastro-intestinal symptoms and hematological indices in diagnosed celiac children –A randomized trialWhat is knownWhat is new |
| title_sort | aglutenic cupcakes for gastro intestinal symptoms and hematological indices in diagnosed celiac children a randomized trialwhat is knownwhat is new |
| topic | Gluten free Cupcakes Children Anthropometry |
| url | http://www.sciencedirect.com/science/article/pii/S266726852500049X |
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