Kencur Supplementation Modulates Interleukin-6 (IL-6) and C-Reactive Protein (CRP) in Response to Muscle Damage Following Eccentric Exercise
Background. Intense or unaccustomed exercise can cause muscle damage and tissue injury, leading to temporary muscle dysfunction and the release of pro-inflammatory cytokines and free radicals. These factors may result in muscle protein breakdown, impaired nutrient absorption, and hindered recovery....
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OVS LLC
2025-03-01
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| Series: | Physical Education Theory and Methodology |
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| Online Access: | https://tmfv.com.ua/journal/article/view/3116 |
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| author | Roy Januardi Irawan Joesoef Roepajadi Heri Wahyudi Noortje Anita Kumaat Abdul Rohim Tualeka Nanda Rimawati Adi Wijayanto |
| author_facet | Roy Januardi Irawan Joesoef Roepajadi Heri Wahyudi Noortje Anita Kumaat Abdul Rohim Tualeka Nanda Rimawati Adi Wijayanto |
| author_sort | Roy Januardi Irawan |
| collection | DOAJ |
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Background. Intense or unaccustomed exercise can cause muscle damage and tissue injury, leading to temporary muscle dysfunction and the release of pro-inflammatory cytokines and free radicals. These factors may result in muscle protein breakdown, impaired nutrient absorption, and hindered recovery.
Objectives. This study aimed to evaluate the effects of Kencur supplementation on plasma IL-6 and CRP levels following eccentric exercise.
Materials and methods. A randomized controlled trial (RCT) with a double-blind, placebo-controlled design was conducted with 40 male recreational students from the State University of Surabaya — Universitas Negeri Surabaya (age: 19.65 ± 1.09 years, BMI: 21.10 ± 1.16 kg, body fat percentage: 22.14 % ± 2.14 %). Participants were randomly assigned to either the Kencur group (200 mg/day) or the placebo group (corn starch 100 mg/day) for a period of 14 days. On the experimental day, participants performed 100 countermovement jumps (CMJ). Blood samples were collected immediately after, 24 hours, and 48 hours post-exercise to measure IL-6 and CRP levels. Repeated Measures ANOVA with Bonferroni Post-hoc tests were used to analyze the data.
Results. The Kencur group showed a significant reduction in plasma IL-6 and CRP levels post-exercise at all time points (p < 0.05), while the placebo group exhibited no substantial changes (p > 0.05).
Conclusions. The findings indicate that Kencur supplementation significantly reduces the inflammatory response by lowering IL-6 and CRP levels following eccentric exercise.
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| format | Article |
| id | doaj-art-a59f3d7bffcd4d35be26fdcd378dbd5c |
| institution | DOAJ |
| issn | 1993-7989 1993-7997 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | OVS LLC |
| record_format | Article |
| series | Physical Education Theory and Methodology |
| spelling | doaj-art-a59f3d7bffcd4d35be26fdcd378dbd5c2025-08-20T02:49:30ZengOVS LLCPhysical Education Theory and Methodology1993-79891993-79972025-03-0125210.17309/tmfv.2025.2.06Kencur Supplementation Modulates Interleukin-6 (IL-6) and C-Reactive Protein (CRP) in Response to Muscle Damage Following Eccentric ExerciseRoy Januardi Irawan0Joesoef Roepajadi1Heri Wahyudi2Noortje Anita Kumaat3Abdul Rohim Tualeka4Nanda Rimawati5Adi Wijayanto 6Universitas Negeri SurabayaUniversitas Negeri SurabayaUniversitas Negeri SurabayaUniversitas Negeri SurabayaUniversitas AirlanggaUniversitas Negeri SurabayaUniversitas Islam Sayyid Ali Rahmatullah Tulungagung Background. Intense or unaccustomed exercise can cause muscle damage and tissue injury, leading to temporary muscle dysfunction and the release of pro-inflammatory cytokines and free radicals. These factors may result in muscle protein breakdown, impaired nutrient absorption, and hindered recovery. Objectives. This study aimed to evaluate the effects of Kencur supplementation on plasma IL-6 and CRP levels following eccentric exercise. Materials and methods. A randomized controlled trial (RCT) with a double-blind, placebo-controlled design was conducted with 40 male recreational students from the State University of Surabaya — Universitas Negeri Surabaya (age: 19.65 ± 1.09 years, BMI: 21.10 ± 1.16 kg, body fat percentage: 22.14 % ± 2.14 %). Participants were randomly assigned to either the Kencur group (200 mg/day) or the placebo group (corn starch 100 mg/day) for a period of 14 days. On the experimental day, participants performed 100 countermovement jumps (CMJ). Blood samples were collected immediately after, 24 hours, and 48 hours post-exercise to measure IL-6 and CRP levels. Repeated Measures ANOVA with Bonferroni Post-hoc tests were used to analyze the data. Results. The Kencur group showed a significant reduction in plasma IL-6 and CRP levels post-exercise at all time points (p < 0.05), while the placebo group exhibited no substantial changes (p > 0.05). Conclusions. The findings indicate that Kencur supplementation significantly reduces the inflammatory response by lowering IL-6 and CRP levels following eccentric exercise. https://tmfv.com.ua/journal/article/view/3116eccentric exerciseROSinflammationimmune response |
| spellingShingle | Roy Januardi Irawan Joesoef Roepajadi Heri Wahyudi Noortje Anita Kumaat Abdul Rohim Tualeka Nanda Rimawati Adi Wijayanto Kencur Supplementation Modulates Interleukin-6 (IL-6) and C-Reactive Protein (CRP) in Response to Muscle Damage Following Eccentric Exercise Physical Education Theory and Methodology eccentric exercise ROS inflammation immune response |
| title | Kencur Supplementation Modulates Interleukin-6 (IL-6) and C-Reactive Protein (CRP) in Response to Muscle Damage Following Eccentric Exercise |
| title_full | Kencur Supplementation Modulates Interleukin-6 (IL-6) and C-Reactive Protein (CRP) in Response to Muscle Damage Following Eccentric Exercise |
| title_fullStr | Kencur Supplementation Modulates Interleukin-6 (IL-6) and C-Reactive Protein (CRP) in Response to Muscle Damage Following Eccentric Exercise |
| title_full_unstemmed | Kencur Supplementation Modulates Interleukin-6 (IL-6) and C-Reactive Protein (CRP) in Response to Muscle Damage Following Eccentric Exercise |
| title_short | Kencur Supplementation Modulates Interleukin-6 (IL-6) and C-Reactive Protein (CRP) in Response to Muscle Damage Following Eccentric Exercise |
| title_sort | kencur supplementation modulates interleukin 6 il 6 and c reactive protein crp in response to muscle damage following eccentric exercise |
| topic | eccentric exercise ROS inflammation immune response |
| url | https://tmfv.com.ua/journal/article/view/3116 |
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