FBXL19 Targeted STK11 Degradation Enhances Cigarette Smoke-Induced Airway Epithelial Cell Cytotoxicity

FBXL19 Targeted STK11 Degradation Enhances Cigarette Smoke-Induced Airway Epithelial Cell Cytotoxicity

Objective: To investigate the effects of cigarette smoke (CS) on Serine/Threonine Kinase 11 (STK11) and to determine STK11’s role in CS-induced airway epithelial cell cytotoxicity.Methods: STK11 expression levels in the lung tissues of smokers with or without COPD and mice exposed to CS or room air...

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Bibliographic Details
Main Authors: Xiuying Li, Sowmya P. Lakshmi, Kiyoshi Uemasu, Zachary Lane, Rajan T. Reddy, Divay Chandra, Chunbin Zou, Yu Jiang, Toru Nyunoya
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:COPD
Subjects:
Serine-Threonine Kinase 11
bronchial airway epithelial cells
cigarette smoke
FBXL19
chronic obstructive pulmonary disease
Online Access:https://www.tandfonline.com/doi/10.1080/15412555.2024.2342797
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