Discovery of amino acid substitutions in penicillin-binding proteins associated with adaptation to D-Ala-D-Lac in vancomycin-resistant Enterococcus faecalis

Discovery of amino acid substitutions in penicillin-binding proteins associated with adaptation to D-Ala-D-Lac in vancomycin-resistant Enterococcus faecalis

The bacterial cell wall, essential for structural integrity, is synthesized with penicillin-binding proteins (PBPs). Vancomycin-resistant enterococci (VRE) evades vancomycin by replacing D-Ala-D-Ala in their cell wall precursors with D-Ala-D-Lac, reducing the drug’s effectiveness. However, how PBPs-...

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Bibliographic Details
Main Authors: Nese Caglayan, Banu Sancak, Zeynep Kanlidere, Tanil Kocagoz
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
vancomycin-resistant
enterococci
penicillin-binding proteins
PBP
bacterial cell wall
peptidoglycan
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1522114/full
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