Mucosal Immunity and Candida albicans Infection
Interactions between mucosal surfaces and microbial microbiota are key to host defense, health, and disease. These surfaces are exposed to high numbers of microbes and must be capable of distinguishing between those that are beneficial or avirulent and those that will invade and cause disease. Our u...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/346307 |
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| _version_ | 1850169806189232128 |
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| author | David L. Moyes Julian R. Naglik |
| author_facet | David L. Moyes Julian R. Naglik |
| author_sort | David L. Moyes |
| collection | DOAJ |
| description | Interactions between mucosal surfaces and microbial microbiota are key to host defense, health, and disease. These surfaces are exposed to high numbers of microbes and must be capable of distinguishing between those that are beneficial or avirulent and those that will invade and cause disease. Our understanding of the mechanisms involved in these discriminatory processes has recently begun to expand as new studies bring to light the importance of epithelial cells and novel immune cell subsets such as Th17 T cells in these processes. Elucidating how these mechanisms function will improve our understanding of many diverse diseases and improve our ability to treat patients suffering from these conditions. In our voyage to discover these mechanisms, mucosal interactions with opportunistic commensal organisms such as the fungus Candida albicans provide insights that are invaluable. Here, we review current knowledge of the interactions between C. albicans and epithelial surfaces and how this may shape our understanding of microbial-mucosal interactions. |
| format | Article |
| id | doaj-art-a597088a38d24cd3843dc5a116adcded |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-a597088a38d24cd3843dc5a116adcded2025-08-20T02:20:38ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/346307346307Mucosal Immunity and Candida albicans InfectionDavid L. Moyes0Julian R. Naglik1Department of Oral Immunology, King's College London Dental Institute, King's College London, Floor 28, Tower Wing, London SE1 9RT, UKDepartment of Oral Immunology, King's College London Dental Institute, King's College London, Floor 28, Tower Wing, London SE1 9RT, UKInteractions between mucosal surfaces and microbial microbiota are key to host defense, health, and disease. These surfaces are exposed to high numbers of microbes and must be capable of distinguishing between those that are beneficial or avirulent and those that will invade and cause disease. Our understanding of the mechanisms involved in these discriminatory processes has recently begun to expand as new studies bring to light the importance of epithelial cells and novel immune cell subsets such as Th17 T cells in these processes. Elucidating how these mechanisms function will improve our understanding of many diverse diseases and improve our ability to treat patients suffering from these conditions. In our voyage to discover these mechanisms, mucosal interactions with opportunistic commensal organisms such as the fungus Candida albicans provide insights that are invaluable. Here, we review current knowledge of the interactions between C. albicans and epithelial surfaces and how this may shape our understanding of microbial-mucosal interactions.http://dx.doi.org/10.1155/2011/346307 |
| spellingShingle | David L. Moyes Julian R. Naglik Mucosal Immunity and Candida albicans Infection Clinical and Developmental Immunology |
| title | Mucosal Immunity and Candida albicans Infection |
| title_full | Mucosal Immunity and Candida albicans Infection |
| title_fullStr | Mucosal Immunity and Candida albicans Infection |
| title_full_unstemmed | Mucosal Immunity and Candida albicans Infection |
| title_short | Mucosal Immunity and Candida albicans Infection |
| title_sort | mucosal immunity and candida albicans infection |
| url | http://dx.doi.org/10.1155/2011/346307 |
| work_keys_str_mv | AT davidlmoyes mucosalimmunityandcandidaalbicansinfection AT julianrnaglik mucosalimmunityandcandidaalbicansinfection |