Metoclopramide-induced rapid-onset psychosis in a child with methylphenidate use: a case report
Background. Metoclopramide, a dopamine antagonist employed for its antiemetic effects, can precipitate neuropsychiatric adverse effects, including extrapyramidal symptoms and, in a few instances, acute psychosis. Although there have been reports of metoclopramide-induced psychosis in elderly indivi...
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Hacettepe University Institute of Child Health
2024-12-01
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| Series: | The Turkish Journal of Pediatrics |
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| Online Access: | https://turkjpediatr.org/article/view/5319 |
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| author | Gökçen İlçioğlu Ekici Gülser Şenses Dinç Ayşegül Neşe Çıtak Kurt |
| author_facet | Gökçen İlçioğlu Ekici Gülser Şenses Dinç Ayşegül Neşe Çıtak Kurt |
| author_sort | Gökçen İlçioğlu Ekici |
| collection | DOAJ |
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Background. Metoclopramide, a dopamine antagonist employed for its antiemetic effects, can precipitate neuropsychiatric adverse effects, including extrapyramidal symptoms and, in a few instances, acute psychosis. Although there have been reports of metoclopramide-induced psychosis in elderly individuals, there is no documentation of such incidents in children as far as we are aware.
Case presentation. This case report describes an 11-year-old girl with a history of mild intellectual disability and attention deficit hyperactivity disorder, managed with 10 mg of methylphenidate daily. She presented to the emergency department with acute gastrointestinal symptoms and was administered two tablets of metoclopramide alongside her regular dose of methylphenidate. Subsequently, she developed psychotic symptoms, disorganized behavior, and agitation. An extensive medical evaluation ruled out other organic pathologies, leading to a diagnosis of rapid-onset psychosis induced by metoclopramide. The psychotic episode, which lasted approximately two weeks, resolved with low-dose antipsychotic treatment.
Conclusions. Children, especially those with neurodevelopmental disorders, are more susceptible to a wide range of side effects. Therefore, this report highlights the necessity for careful pharmacological management. Additionally, this case represents a significant contribution to the scientific literature by being the first to document metoclopramide-induced acute psychosis in children to the best of our knowledge.
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| format | Article |
| id | doaj-art-a592335a4baf48dc89ff2fe01c0ad144 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-a592335a4baf48dc89ff2fe01c0ad1442025-08-20T02:55:42ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64212024-12-0166610.24953/turkjpediatr.2024.5319Metoclopramide-induced rapid-onset psychosis in a child with methylphenidate use: a case reportGökçen İlçioğlu Ekici0https://orcid.org/0000-0001-6245-396XGülser Şenses Dinç1https://orcid.org/0000-0001-5556-3175Ayşegül Neşe Çıtak Kurt2https://orcid.org/0000-0002-7277-3550Department of Child and Adolescent Psychiatry, Ankara Bilkent City Hospital, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, TürkiyeDepartment of Child and Adolescent Psychiatry, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, TürkiyeDepartment of Pediatric Neurology, Ankara Bilkent City Hospital, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, Türkiye Background. Metoclopramide, a dopamine antagonist employed for its antiemetic effects, can precipitate neuropsychiatric adverse effects, including extrapyramidal symptoms and, in a few instances, acute psychosis. Although there have been reports of metoclopramide-induced psychosis in elderly individuals, there is no documentation of such incidents in children as far as we are aware. Case presentation. This case report describes an 11-year-old girl with a history of mild intellectual disability and attention deficit hyperactivity disorder, managed with 10 mg of methylphenidate daily. She presented to the emergency department with acute gastrointestinal symptoms and was administered two tablets of metoclopramide alongside her regular dose of methylphenidate. Subsequently, she developed psychotic symptoms, disorganized behavior, and agitation. An extensive medical evaluation ruled out other organic pathologies, leading to a diagnosis of rapid-onset psychosis induced by metoclopramide. The psychotic episode, which lasted approximately two weeks, resolved with low-dose antipsychotic treatment. Conclusions. Children, especially those with neurodevelopmental disorders, are more susceptible to a wide range of side effects. Therefore, this report highlights the necessity for careful pharmacological management. Additionally, this case represents a significant contribution to the scientific literature by being the first to document metoclopramide-induced acute psychosis in children to the best of our knowledge. https://turkjpediatr.org/article/view/5319metoclopramideacute psychosischildrenadverse drug reactions |
| spellingShingle | Gökçen İlçioğlu Ekici Gülser Şenses Dinç Ayşegül Neşe Çıtak Kurt Metoclopramide-induced rapid-onset psychosis in a child with methylphenidate use: a case report The Turkish Journal of Pediatrics metoclopramide acute psychosis children adverse drug reactions |
| title | Metoclopramide-induced rapid-onset psychosis in a child with methylphenidate use: a case report |
| title_full | Metoclopramide-induced rapid-onset psychosis in a child with methylphenidate use: a case report |
| title_fullStr | Metoclopramide-induced rapid-onset psychosis in a child with methylphenidate use: a case report |
| title_full_unstemmed | Metoclopramide-induced rapid-onset psychosis in a child with methylphenidate use: a case report |
| title_short | Metoclopramide-induced rapid-onset psychosis in a child with methylphenidate use: a case report |
| title_sort | metoclopramide induced rapid onset psychosis in a child with methylphenidate use a case report |
| topic | metoclopramide acute psychosis children adverse drug reactions |
| url | https://turkjpediatr.org/article/view/5319 |
| work_keys_str_mv | AT gokcenilciogluekici metoclopramideinducedrapidonsetpsychosisinachildwithmethylphenidateuseacasereport AT gulsersensesdinc metoclopramideinducedrapidonsetpsychosisinachildwithmethylphenidateuseacasereport AT aysegulnesecıtakkurt metoclopramideinducedrapidonsetpsychosisinachildwithmethylphenidateuseacasereport |