Weizmannia coagulans BC99 modulate gut microbiota after Helicobacter pylori eradication: A randomized double-blind placebo-controlled trial
Probiotics interventions may contribute to eradicate Helicobacter pylori infection and reduce gastrointestinal symptom, but their mechanisms require more research. This study involved 100H. pylori-positive adults, randomly assigned to either Weizmannia coagulans BC99 group or Placebo group. Both gro...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-02-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464625000234 |
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| author | Ying Wu Shirui Zhai Caie Wang Zhouya Bai Pingping Tian Shanshan Tie Yao Wang Yingjian Zhang Lina Zhao Shaobin Gu |
| author_facet | Ying Wu Shirui Zhai Caie Wang Zhouya Bai Pingping Tian Shanshan Tie Yao Wang Yingjian Zhang Lina Zhao Shaobin Gu |
| author_sort | Ying Wu |
| collection | DOAJ |
| description | Probiotics interventions may contribute to eradicate Helicobacter pylori infection and reduce gastrointestinal symptom, but their mechanisms require more research. This study involved 100H. pylori-positive adults, randomly assigned to either Weizmannia coagulans BC99 group or Placebo group. Both groups were received bismuth quadruple therapy for 4 weeks and took either BC99 or placebo for 6 weeks. After 6 weeks, BC99 significantly reduced eradication rate and happening of adverse events. BC99 reduced GSRS score, particularly the severity of stomach-abdominal pain during hunger symptoms. Additionally, BC99 reduced the disruption of bismuth quadruple therapy on the gut microbiota, particularly significantly increasing the abundance of Prevotella, Bacillus, Candidatus_Saccharimonas and reducing the abundance of Lachnoclostridium, Intestinibacter, Holdemania, Desulfovibrio. These findings supported the use of W. coagulans BC99 in combination with BQT in the clinical management of patients with H. pylori infection. |
| format | Article |
| id | doaj-art-a5919a78826b45f282f4fe2ba0f10612 |
| institution | Kabale University |
| issn | 1756-4646 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj-art-a5919a78826b45f282f4fe2ba0f106122025-02-09T04:59:57ZengElsevierJournal of Functional Foods1756-46462025-02-01125106681Weizmannia coagulans BC99 modulate gut microbiota after Helicobacter pylori eradication: A randomized double-blind placebo-controlled trialYing Wu0Shirui Zhai1Caie Wang2Zhouya Bai3Pingping Tian4Shanshan Tie5Yao Wang6Yingjian Zhang7Lina Zhao8Shaobin Gu9College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China; Henan Engineering Research Center of Food Microbiology, Henan University of Science and Technology, Luoyang 471000, ChinaCollege of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, ChinaDepartment of Pharmacy, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 47100, ChinaCollege of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, ChinaCollege of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, ChinaCollege of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China; Henan Engineering Research Center of Food Microbiology, Henan University of Science and Technology, Luoyang 471000, ChinaCollege of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China; National Demonstration Center for Experimental Food Processing and Safety Education, Luoyang 471000, ChinaDepartment of Pharmacy, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang 47100, China; Department of Gastroenterology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang 471000, ChinaHenan Engineering Research Center of Food Microbiology, Henan University of Science and Technology, Luoyang 471000, China; Corresponding authors.College of Food and Bioengineering, Henan University of Science and Technology, Luoyang 471000, China; Corresponding authors.Probiotics interventions may contribute to eradicate Helicobacter pylori infection and reduce gastrointestinal symptom, but their mechanisms require more research. This study involved 100H. pylori-positive adults, randomly assigned to either Weizmannia coagulans BC99 group or Placebo group. Both groups were received bismuth quadruple therapy for 4 weeks and took either BC99 or placebo for 6 weeks. After 6 weeks, BC99 significantly reduced eradication rate and happening of adverse events. BC99 reduced GSRS score, particularly the severity of stomach-abdominal pain during hunger symptoms. Additionally, BC99 reduced the disruption of bismuth quadruple therapy on the gut microbiota, particularly significantly increasing the abundance of Prevotella, Bacillus, Candidatus_Saccharimonas and reducing the abundance of Lachnoclostridium, Intestinibacter, Holdemania, Desulfovibrio. These findings supported the use of W. coagulans BC99 in combination with BQT in the clinical management of patients with H. pylori infection.http://www.sciencedirect.com/science/article/pii/S1756464625000234Weizmannia coagulans BC99Helicobacter pylori infectionEradication rateRandomized controlled trialGut microbiota |
| spellingShingle | Ying Wu Shirui Zhai Caie Wang Zhouya Bai Pingping Tian Shanshan Tie Yao Wang Yingjian Zhang Lina Zhao Shaobin Gu Weizmannia coagulans BC99 modulate gut microbiota after Helicobacter pylori eradication: A randomized double-blind placebo-controlled trial Journal of Functional Foods Weizmannia coagulans BC99 Helicobacter pylori infection Eradication rate Randomized controlled trial Gut microbiota |
| title | Weizmannia coagulans BC99 modulate gut microbiota after Helicobacter pylori eradication: A randomized double-blind placebo-controlled trial |
| title_full | Weizmannia coagulans BC99 modulate gut microbiota after Helicobacter pylori eradication: A randomized double-blind placebo-controlled trial |
| title_fullStr | Weizmannia coagulans BC99 modulate gut microbiota after Helicobacter pylori eradication: A randomized double-blind placebo-controlled trial |
| title_full_unstemmed | Weizmannia coagulans BC99 modulate gut microbiota after Helicobacter pylori eradication: A randomized double-blind placebo-controlled trial |
| title_short | Weizmannia coagulans BC99 modulate gut microbiota after Helicobacter pylori eradication: A randomized double-blind placebo-controlled trial |
| title_sort | weizmannia coagulans bc99 modulate gut microbiota after helicobacter pylori eradication a randomized double blind placebo controlled trial |
| topic | Weizmannia coagulans BC99 Helicobacter pylori infection Eradication rate Randomized controlled trial Gut microbiota |
| url | http://www.sciencedirect.com/science/article/pii/S1756464625000234 |
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