Increased serum interleukin-31 levels correlate with pruritus in psoriatic patients: a cross-sectional study in Vietnam
Psoriasis is recognized not only as a skin disease but also as a systemic disorder. Interleukin-31 (IL-31) may be associated with psoriasis and systemic inflammation. We aimed to quantify serum IL-31 levels in patients with psoriasis and explore their associations with specific clinical manifestati...
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| Language: | English |
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PAGEPress Publications
2024-11-01
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| Series: | Dermatology Reports |
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| Online Access: | https://www.pagepress.org/journals/dr/article/view/10090 |
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| _version_ | 1846151126679814144 |
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| author | Chuyen Thi Hong Nguyen Liem Viet Quoc Tran |
| author_facet | Chuyen Thi Hong Nguyen Liem Viet Quoc Tran |
| author_sort | Chuyen Thi Hong Nguyen |
| collection | DOAJ |
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Psoriasis is recognized not only as a skin disease but also as a systemic disorder. Interleukin-31 (IL-31) may be associated with psoriasis and systemic inflammation. We aimed to quantify serum IL-31 levels in patients with psoriasis and explore their associations with specific clinical manifestations. 30 patients with psoriasis and 30 healthy controls were included in this study. Demographic information and clinical characteristics were obtained through physical examination and medical history review. Serum IL-31 levels were measured using an enzyme-linked immunosorbent assay. IL-31 concentration was significantly higher in patients with psoriasis than in the control group (p<0.001). Patients with psoriasis vulgaris, psoriasis erythroderma, and pustular psoriasis had significantly higher serum IL-31 levels than healthy controls. Additionally, serum IL-31 levels were associated with itch numerical rating scale (NRS) scores and body mass index (BMI) but not with disease severity as measured by the Psoriasis Area and Severity Index (PASI). In patients with psoriasis, increased serum IL-31 levels correlated with itch severity but not with PASI. This suggests that IL-31 may play a critical role in the pathogenesis of psoriasis and could be a valuable target for further studies and therapeutic interventions.
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| format | Article |
| id | doaj-art-a58b16d61b464bfd86cc86f3b54c67f2 |
| institution | Kabale University |
| issn | 2036-7392 2036-7406 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Dermatology Reports |
| spelling | doaj-art-a58b16d61b464bfd86cc86f3b54c67f22024-11-28T01:34:07ZengPAGEPress PublicationsDermatology Reports2036-73922036-74062024-11-0110.4081/dr.2024.10090Increased serum interleukin-31 levels correlate with pruritus in psoriatic patients: a cross-sectional study in VietnamChuyen Thi Hong Nguyen0Liem Viet Quoc Tran1Department of Dermatology, University of Medicine and Pharmacy, Ho Chi Minh CityDepartment of Dermatology, University of Medicine and Pharmacy, Ho Chi Minh City Psoriasis is recognized not only as a skin disease but also as a systemic disorder. Interleukin-31 (IL-31) may be associated with psoriasis and systemic inflammation. We aimed to quantify serum IL-31 levels in patients with psoriasis and explore their associations with specific clinical manifestations. 30 patients with psoriasis and 30 healthy controls were included in this study. Demographic information and clinical characteristics were obtained through physical examination and medical history review. Serum IL-31 levels were measured using an enzyme-linked immunosorbent assay. IL-31 concentration was significantly higher in patients with psoriasis than in the control group (p<0.001). Patients with psoriasis vulgaris, psoriasis erythroderma, and pustular psoriasis had significantly higher serum IL-31 levels than healthy controls. Additionally, serum IL-31 levels were associated with itch numerical rating scale (NRS) scores and body mass index (BMI) but not with disease severity as measured by the Psoriasis Area and Severity Index (PASI). In patients with psoriasis, increased serum IL-31 levels correlated with itch severity but not with PASI. This suggests that IL-31 may play a critical role in the pathogenesis of psoriasis and could be a valuable target for further studies and therapeutic interventions. https://www.pagepress.org/journals/dr/article/view/10090Interleukin-31psoriasispruritus |
| spellingShingle | Chuyen Thi Hong Nguyen Liem Viet Quoc Tran Increased serum interleukin-31 levels correlate with pruritus in psoriatic patients: a cross-sectional study in Vietnam Dermatology Reports Interleukin-31 psoriasis pruritus |
| title | Increased serum interleukin-31 levels correlate with pruritus in psoriatic patients: a cross-sectional study in Vietnam |
| title_full | Increased serum interleukin-31 levels correlate with pruritus in psoriatic patients: a cross-sectional study in Vietnam |
| title_fullStr | Increased serum interleukin-31 levels correlate with pruritus in psoriatic patients: a cross-sectional study in Vietnam |
| title_full_unstemmed | Increased serum interleukin-31 levels correlate with pruritus in psoriatic patients: a cross-sectional study in Vietnam |
| title_short | Increased serum interleukin-31 levels correlate with pruritus in psoriatic patients: a cross-sectional study in Vietnam |
| title_sort | increased serum interleukin 31 levels correlate with pruritus in psoriatic patients a cross sectional study in vietnam |
| topic | Interleukin-31 psoriasis pruritus |
| url | https://www.pagepress.org/journals/dr/article/view/10090 |
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