Comparison of CKD-EPI Cystatin C and Creatinine Glomerular Filtration Rate Estimation Equations in Asian Indians
Background. Chronic kidney disease (CKD) is identified in the general population using estimated glomerular filtration rates (eGFR) calculated from a serum creatinine-based equation, the chronic kidney disease-epidemiology collaboration (CKD-EPI) equation. Using serum cystatin C in combination may i...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2014/746497 |
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| author | Boon Wee Teo Charumathi Sabanayagam Jiemin Liao Qi Chun Toh Sharon Saw Tien Yin Wong Sunil Sethi |
| author_facet | Boon Wee Teo Charumathi Sabanayagam Jiemin Liao Qi Chun Toh Sharon Saw Tien Yin Wong Sunil Sethi |
| author_sort | Boon Wee Teo |
| collection | DOAJ |
| description | Background. Chronic kidney disease (CKD) is identified in the general population using estimated glomerular filtration rates (eGFR) calculated from a serum creatinine-based equation, the chronic kidney disease-epidemiology collaboration (CKD-EPI) equation. Using serum cystatin C in combination may improve eGFR accuracy. We evaluated the new CKD-EPI equations incorporating cystatin C in a population of Asian Indians in classifying CKD across body mass index, diabetes, and hypertension status. Methods. We retrieved standardized serum creatinine and serum cystatin C data from a cohort of 2877 Asian Indians aged 40–80 years from the Singapore Indian Eye Study and calculated eGFR (in mL/min/1.73 m2) with the new CKD-EPI equations and serum creatinine only equation. Results. The creatinine only equation mean eGFR (88 ± 17) was similar to using spline Log cystatin C (88 ± 22). The lowest mean eGFR (81 ± 21) was obtained with the spline Log cystatin C—age, sex, and weight equation. The creatinine only equation had the fewest participants (7.1%) with eGFR <60 and spline Log cystatin C—age, sex, and weight equation had the most (16.1%). Conclusions. Using serum cystatin C resulted in widely varying eGFR which significantly affected the classification of chronic kidney disease. |
| format | Article |
| id | doaj-art-a58073129f4c4beba0837b941709e1d3 |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-a58073129f4c4beba0837b941709e1d32025-08-20T03:38:31ZengWileyInternational Journal of Nephrology2090-214X2090-21582014-01-01201410.1155/2014/746497746497Comparison of CKD-EPI Cystatin C and Creatinine Glomerular Filtration Rate Estimation Equations in Asian IndiansBoon Wee Teo0Charumathi Sabanayagam1Jiemin Liao2Qi Chun Toh3Sharon Saw4Tien Yin Wong5Sunil Sethi6Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, 1E Kent Ridge Road, Level 10 NUHS Tower Block, 119228, SingaporeSingapore Eye Research Institute, c/o Singapore National Eye Center, 11 Third Hospital Avenue, 168751, SingaporeDepartment of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, 1E Kent Ridge Road, NUHS Tower Block, 119228, SingaporeDepartment of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, 1E Kent Ridge Road, Level 10 NUHS Tower Block, 119228, SingaporeDepartment of Laboratory Medicine, National University Hospital and National University Health System, 5 Lower Kent Ridge Road, 119074, SingaporeSingapore Eye Research Institute, c/o Singapore National Eye Center, 11 Third Hospital Avenue, 168751, SingaporeDepartment of Pathology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, 1E Kent Ridge Road, Level 10 NUHS Tower Block, 119228, SingaporeBackground. Chronic kidney disease (CKD) is identified in the general population using estimated glomerular filtration rates (eGFR) calculated from a serum creatinine-based equation, the chronic kidney disease-epidemiology collaboration (CKD-EPI) equation. Using serum cystatin C in combination may improve eGFR accuracy. We evaluated the new CKD-EPI equations incorporating cystatin C in a population of Asian Indians in classifying CKD across body mass index, diabetes, and hypertension status. Methods. We retrieved standardized serum creatinine and serum cystatin C data from a cohort of 2877 Asian Indians aged 40–80 years from the Singapore Indian Eye Study and calculated eGFR (in mL/min/1.73 m2) with the new CKD-EPI equations and serum creatinine only equation. Results. The creatinine only equation mean eGFR (88 ± 17) was similar to using spline Log cystatin C (88 ± 22). The lowest mean eGFR (81 ± 21) was obtained with the spline Log cystatin C—age, sex, and weight equation. The creatinine only equation had the fewest participants (7.1%) with eGFR <60 and spline Log cystatin C—age, sex, and weight equation had the most (16.1%). Conclusions. Using serum cystatin C resulted in widely varying eGFR which significantly affected the classification of chronic kidney disease.http://dx.doi.org/10.1155/2014/746497 |
| spellingShingle | Boon Wee Teo Charumathi Sabanayagam Jiemin Liao Qi Chun Toh Sharon Saw Tien Yin Wong Sunil Sethi Comparison of CKD-EPI Cystatin C and Creatinine Glomerular Filtration Rate Estimation Equations in Asian Indians International Journal of Nephrology |
| title | Comparison of CKD-EPI Cystatin C and Creatinine Glomerular Filtration Rate Estimation Equations in Asian Indians |
| title_full | Comparison of CKD-EPI Cystatin C and Creatinine Glomerular Filtration Rate Estimation Equations in Asian Indians |
| title_fullStr | Comparison of CKD-EPI Cystatin C and Creatinine Glomerular Filtration Rate Estimation Equations in Asian Indians |
| title_full_unstemmed | Comparison of CKD-EPI Cystatin C and Creatinine Glomerular Filtration Rate Estimation Equations in Asian Indians |
| title_short | Comparison of CKD-EPI Cystatin C and Creatinine Glomerular Filtration Rate Estimation Equations in Asian Indians |
| title_sort | comparison of ckd epi cystatin c and creatinine glomerular filtration rate estimation equations in asian indians |
| url | http://dx.doi.org/10.1155/2014/746497 |
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