The validity of the renal Doppler resistivity index in renal allograft infections
Background The correlations between the intra-renal resistive index (RRI) and renal histopathology characteristics, especially in those with infected allografts, have not been sufficiently investigated in renal transplant recipients. We aimed to examine the correlation between RRI and renal allograf...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Renal Failure |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2462443 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1825206678010724352 |
|---|---|
| author | Moataz Fatthy Karim M. Soliman Éva Csongrádi Abd El Rahman Marzouk Ahmed Fathy Ahmed Fayed |
| author_facet | Moataz Fatthy Karim M. Soliman Éva Csongrádi Abd El Rahman Marzouk Ahmed Fathy Ahmed Fayed |
| author_sort | Moataz Fatthy |
| collection | DOAJ |
| description | Background The correlations between the intra-renal resistive index (RRI) and renal histopathology characteristics, especially in those with infected allografts, have not been sufficiently investigated in renal transplant recipients. We aimed to examine the correlation between RRI and renal allograft infection in these subjects.Methods One hundred nine renal allograft recipients were recruited, and RRI was evaluated for correlation with renal allograft infection. Based on laboratory and histopathological findings, 64 renal-allograft recipients were recruited for the infected group, and 45 were recruited for the non-infected group.Results The causes of allograft infection were Cytomegalovirus (CMV) infection (30.3%), urinary tract infections (UTI) (18.3%), and polyomavirus 1 (BK virus) infections (10.1%). There was a statistically significant difference in RRI in those with allograft infections, with the ROC curve for detection of infection utilizing RRI demonstrated an Area Under Curve 0.634 (p-value 0.015; cutoff value: 0.765; CI:0.527–0.742), with a specificity of 64.4% and a sensitivity of 68.8%.Conclusion Normal renal graft arterial resistivity index values, despite a renal allograft dysfunction, may be indicative of allograft infection, guiding clinicians’ decisions regarding kidney biopsy and facilitating further biopsy interpretations. |
| format | Article |
| id | doaj-art-a57c70812f1744ca9a84d9221fb9689f |
| institution | Kabale University |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-a57c70812f1744ca9a84d9221fb9689f2025-02-07T07:19:01ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2025.2462443The validity of the renal Doppler resistivity index in renal allograft infectionsMoataz Fatthy0Karim M. Soliman1Éva Csongrádi2Abd El Rahman Marzouk3Ahmed Fathy4Ahmed Fayed5Nephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University, Cairo, EgyptDivision of Nephrology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USACentre for Translational Medicine, Semmelweis University, Budapest, HungaryNephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University, Cairo, EgyptNephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University, Cairo, EgyptNephrology Unit, Internal Medicine Department, Kasr Alainy School of Medicine, Cairo University, Cairo, EgyptBackground The correlations between the intra-renal resistive index (RRI) and renal histopathology characteristics, especially in those with infected allografts, have not been sufficiently investigated in renal transplant recipients. We aimed to examine the correlation between RRI and renal allograft infection in these subjects.Methods One hundred nine renal allograft recipients were recruited, and RRI was evaluated for correlation with renal allograft infection. Based on laboratory and histopathological findings, 64 renal-allograft recipients were recruited for the infected group, and 45 were recruited for the non-infected group.Results The causes of allograft infection were Cytomegalovirus (CMV) infection (30.3%), urinary tract infections (UTI) (18.3%), and polyomavirus 1 (BK virus) infections (10.1%). There was a statistically significant difference in RRI in those with allograft infections, with the ROC curve for detection of infection utilizing RRI demonstrated an Area Under Curve 0.634 (p-value 0.015; cutoff value: 0.765; CI:0.527–0.742), with a specificity of 64.4% and a sensitivity of 68.8%.Conclusion Normal renal graft arterial resistivity index values, despite a renal allograft dysfunction, may be indicative of allograft infection, guiding clinicians’ decisions regarding kidney biopsy and facilitating further biopsy interpretations.https://www.tandfonline.com/doi/10.1080/0886022X.2025.2462443Renal resistive indexrenal allograft infectionCMVBK virus |
| spellingShingle | Moataz Fatthy Karim M. Soliman Éva Csongrádi Abd El Rahman Marzouk Ahmed Fathy Ahmed Fayed The validity of the renal Doppler resistivity index in renal allograft infections Renal Failure Renal resistive index renal allograft infection CMV BK virus |
| title | The validity of the renal Doppler resistivity index in renal allograft infections |
| title_full | The validity of the renal Doppler resistivity index in renal allograft infections |
| title_fullStr | The validity of the renal Doppler resistivity index in renal allograft infections |
| title_full_unstemmed | The validity of the renal Doppler resistivity index in renal allograft infections |
| title_short | The validity of the renal Doppler resistivity index in renal allograft infections |
| title_sort | validity of the renal doppler resistivity index in renal allograft infections |
| topic | Renal resistive index renal allograft infection CMV BK virus |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2462443 |
| work_keys_str_mv | AT moatazfatthy thevalidityoftherenaldopplerresistivityindexinrenalallograftinfections AT karimmsoliman thevalidityoftherenaldopplerresistivityindexinrenalallograftinfections AT evacsongradi thevalidityoftherenaldopplerresistivityindexinrenalallograftinfections AT abdelrahmanmarzouk thevalidityoftherenaldopplerresistivityindexinrenalallograftinfections AT ahmedfathy thevalidityoftherenaldopplerresistivityindexinrenalallograftinfections AT ahmedfayed thevalidityoftherenaldopplerresistivityindexinrenalallograftinfections AT moatazfatthy validityoftherenaldopplerresistivityindexinrenalallograftinfections AT karimmsoliman validityoftherenaldopplerresistivityindexinrenalallograftinfections AT evacsongradi validityoftherenaldopplerresistivityindexinrenalallograftinfections AT abdelrahmanmarzouk validityoftherenaldopplerresistivityindexinrenalallograftinfections AT ahmedfathy validityoftherenaldopplerresistivityindexinrenalallograftinfections AT ahmedfayed validityoftherenaldopplerresistivityindexinrenalallograftinfections |