Licensing virus-specific T cells to secrete the neutrophil attracting chemokine CXCL-8 during hepatitis B virus infection.
T cell functional plasticity helps tailor antiviral immunity during different phases of infections. We tested whether, during different phases of HBV infection, virus-specific T cells can acquire specific proinflammatory functions that could drive granulocyte/mononuclear cell liver infiltration. Mul...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0023330&type=printable |
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| author | Adam J Gehring Sarene Koh Adeline Chia Komathi Paramasivam Valerie Suk Peng Chew Zi Zong Ho Kang Hoe Lee Mala K Maini Krishnakumar Madhavan Seng Gee Lim Antonio Bertoletti |
| author_facet | Adam J Gehring Sarene Koh Adeline Chia Komathi Paramasivam Valerie Suk Peng Chew Zi Zong Ho Kang Hoe Lee Mala K Maini Krishnakumar Madhavan Seng Gee Lim Antonio Bertoletti |
| author_sort | Adam J Gehring |
| collection | DOAJ |
| description | T cell functional plasticity helps tailor antiviral immunity during different phases of infections. We tested whether, during different phases of HBV infection, virus-specific T cells can acquire specific proinflammatory functions that could drive granulocyte/mononuclear cell liver infiltration. Multifunctional analysis of HBV-specific T cells during acute and chronic HBV infection revealed that HBV-specific T cells had the capacity to produce the neutrophil chemokine CXCL-8 but not IL-17. CXCL-8 producing T cells were detectable in the liver of chronic HBV patients with active hepatitis; while in acute HBV patients CXCL-8 production by T cells was temporally limited to the acute phase of disease, concomitant with the peak of liver inflammation. Characterization of the conditions necessary for the development of CXCL-8 producing T cells showed a requirement for IL-7 and IL-15 during T cell expansion. These data show that functional plasticity of virus-specific T cells spontaneously occurs during HBV infection and that an environment rich IL-7 and IL-15 can license T cells with the ability to produce CXCL-8 and potentially influence liver pathology. |
| format | Article |
| id | doaj-art-a57b8fd111ea4ebdbda10dda95b70013 |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-a57b8fd111ea4ebdbda10dda95b700132025-08-20T03:09:48ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0168e2333010.1371/journal.pone.0023330Licensing virus-specific T cells to secrete the neutrophil attracting chemokine CXCL-8 during hepatitis B virus infection.Adam J GehringSarene KohAdeline ChiaKomathi ParamasivamValerie Suk Peng ChewZi Zong HoKang Hoe LeeMala K MainiKrishnakumar MadhavanSeng Gee LimAntonio BertolettiT cell functional plasticity helps tailor antiviral immunity during different phases of infections. We tested whether, during different phases of HBV infection, virus-specific T cells can acquire specific proinflammatory functions that could drive granulocyte/mononuclear cell liver infiltration. Multifunctional analysis of HBV-specific T cells during acute and chronic HBV infection revealed that HBV-specific T cells had the capacity to produce the neutrophil chemokine CXCL-8 but not IL-17. CXCL-8 producing T cells were detectable in the liver of chronic HBV patients with active hepatitis; while in acute HBV patients CXCL-8 production by T cells was temporally limited to the acute phase of disease, concomitant with the peak of liver inflammation. Characterization of the conditions necessary for the development of CXCL-8 producing T cells showed a requirement for IL-7 and IL-15 during T cell expansion. These data show that functional plasticity of virus-specific T cells spontaneously occurs during HBV infection and that an environment rich IL-7 and IL-15 can license T cells with the ability to produce CXCL-8 and potentially influence liver pathology.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0023330&type=printable |
| spellingShingle | Adam J Gehring Sarene Koh Adeline Chia Komathi Paramasivam Valerie Suk Peng Chew Zi Zong Ho Kang Hoe Lee Mala K Maini Krishnakumar Madhavan Seng Gee Lim Antonio Bertoletti Licensing virus-specific T cells to secrete the neutrophil attracting chemokine CXCL-8 during hepatitis B virus infection. PLoS ONE |
| title | Licensing virus-specific T cells to secrete the neutrophil attracting chemokine CXCL-8 during hepatitis B virus infection. |
| title_full | Licensing virus-specific T cells to secrete the neutrophil attracting chemokine CXCL-8 during hepatitis B virus infection. |
| title_fullStr | Licensing virus-specific T cells to secrete the neutrophil attracting chemokine CXCL-8 during hepatitis B virus infection. |
| title_full_unstemmed | Licensing virus-specific T cells to secrete the neutrophil attracting chemokine CXCL-8 during hepatitis B virus infection. |
| title_short | Licensing virus-specific T cells to secrete the neutrophil attracting chemokine CXCL-8 during hepatitis B virus infection. |
| title_sort | licensing virus specific t cells to secrete the neutrophil attracting chemokine cxcl 8 during hepatitis b virus infection |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0023330&type=printable |
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