Phenotyping the males of mouse and rat strains with genetically defined behavioral disturbances in a model of sexual activation
Sexual behavior is one of the biologically highly relevant types of behavior. Sexual arousal, or an initial stage of sexual behavior, is of particular interest since it triggers all the following events but still remains the least known element of this behavior. Sexual dysfunctions are caused by agi...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2015-12-01
|
| Series: | Вавиловский журнал генетики и селекции |
| Subjects: | |
| Online Access: | https://vavilov.elpub.ru/jour/article/view/428 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832575246431944704 |
|---|---|
| author | M. A. Tikhonova T. G. Amstislavskaya |
| author_facet | M. A. Tikhonova T. G. Amstislavskaya |
| author_sort | M. A. Tikhonova |
| collection | DOAJ |
| description | Sexual behavior is one of the biologically highly relevant types of behavior. Sexual arousal, or an initial stage of sexual behavior, is of particular interest since it triggers all the following events but still remains the least known element of this behavior. Sexual dysfunctions are caused by aging, stress, or side effects of psychotropic drugs; they are symptoms of a variety of neurological and psychiatric disorders. Therefore, the study of sexual behavior appears to be an important step in modeling various animal pathologies and the effects of psychotropic drugs. We have performed phenotyping of animals with hereditary predisposition to catalepsy using our previous development, a model of male sexual arousal, and examined the relationship between catalepsy and sexual arousal. The main gene for a high predisposition to catalepsy was shown to be associated with the expression of sexual motivation, but not with the hormonal component of sexual arousal (increase in plasma testosterone levels following exposure to a receptive female). ASC (Antidepressant Sensitive Catalepsy) mice, proposed as a model of depression, had a decreased manifestation of sexual motivation, while male GC (Genetic Catalepsy) strain rats had enhanced sexual motivation. Noteworthy, highly excitable GC strain animals corresponding to the manic pole of bipolar disorders prevail at the current stage of breeding. Our results are in a good agreement with clinical data that indicate reduced libido in depressed patients and hypersexuality in people with bipolar disorder. |
| format | Article |
| id | doaj-art-a5754445313f4506b5dc8dd85ffb6634 |
| institution | Kabale University |
| issn | 2500-3259 |
| language | English |
| publishDate | 2015-12-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj-art-a5754445313f4506b5dc8dd85ffb66342025-02-01T09:58:02ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592015-12-0119441341910.18699/VJ15.054387Phenotyping the males of mouse and rat strains with genetically defined behavioral disturbances in a model of sexual activationM. A. Tikhonova0T. G. Amstislavskaya1Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia Institute of Cytology and Genetics SB RAS, Novosibirsk, RussiaScientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia Institute of Cytology and Genetics SB RAS, Novosibirsk, RussiaSexual behavior is one of the biologically highly relevant types of behavior. Sexual arousal, or an initial stage of sexual behavior, is of particular interest since it triggers all the following events but still remains the least known element of this behavior. Sexual dysfunctions are caused by aging, stress, or side effects of psychotropic drugs; they are symptoms of a variety of neurological and psychiatric disorders. Therefore, the study of sexual behavior appears to be an important step in modeling various animal pathologies and the effects of psychotropic drugs. We have performed phenotyping of animals with hereditary predisposition to catalepsy using our previous development, a model of male sexual arousal, and examined the relationship between catalepsy and sexual arousal. The main gene for a high predisposition to catalepsy was shown to be associated with the expression of sexual motivation, but not with the hormonal component of sexual arousal (increase in plasma testosterone levels following exposure to a receptive female). ASC (Antidepressant Sensitive Catalepsy) mice, proposed as a model of depression, had a decreased manifestation of sexual motivation, while male GC (Genetic Catalepsy) strain rats had enhanced sexual motivation. Noteworthy, highly excitable GC strain animals corresponding to the manic pole of bipolar disorders prevail at the current stage of breeding. Our results are in a good agreement with clinical data that indicate reduced libido in depressed patients and hypersexuality in people with bipolar disorder.https://vavilov.elpub.ru/jour/article/view/428male sexual behaviormouseratsexual activationsexual motivationtestosteronecatalepsyselective models of psychopathologyaffective disorders |
| spellingShingle | M. A. Tikhonova T. G. Amstislavskaya Phenotyping the males of mouse and rat strains with genetically defined behavioral disturbances in a model of sexual activation Вавиловский журнал генетики и селекции male sexual behavior mouse rat sexual activation sexual motivation testosterone catalepsy selective models of psychopathology affective disorders |
| title | Phenotyping the males of mouse and rat strains with genetically defined behavioral disturbances in a model of sexual activation |
| title_full | Phenotyping the males of mouse and rat strains with genetically defined behavioral disturbances in a model of sexual activation |
| title_fullStr | Phenotyping the males of mouse and rat strains with genetically defined behavioral disturbances in a model of sexual activation |
| title_full_unstemmed | Phenotyping the males of mouse and rat strains with genetically defined behavioral disturbances in a model of sexual activation |
| title_short | Phenotyping the males of mouse and rat strains with genetically defined behavioral disturbances in a model of sexual activation |
| title_sort | phenotyping the males of mouse and rat strains with genetically defined behavioral disturbances in a model of sexual activation |
| topic | male sexual behavior mouse rat sexual activation sexual motivation testosterone catalepsy selective models of psychopathology affective disorders |
| url | https://vavilov.elpub.ru/jour/article/view/428 |
| work_keys_str_mv | AT matikhonova phenotypingthemalesofmouseandratstrainswithgeneticallydefinedbehavioraldisturbancesinamodelofsexualactivation AT tgamstislavskaya phenotypingthemalesofmouseandratstrainswithgeneticallydefinedbehavioraldisturbancesinamodelofsexualactivation |