Genetic predisposition to immune dysregulation and extracellular matrix remodeling in cardiac arrhythmia reveals potential mediation by SPP1+ macrophages

Genetic predisposition to immune dysregulation and extracellular matrix remodeling in cardiac arrhythmia reveals potential mediation by SPP1+ macrophages

IntroductionCardiac arrhythmia frequently co-presents with structural abnormalities such as cardiomyopathy and myocardial fibrosis, creating a bidirectional relationship where electrical disturbances and structural remodeling exacerbate each other. Current genetic studies focus on ion channel varian...

Full description

Saved in:
Bibliographic Details
Main Authors: Jie-Yuan Jin, Shuai Guo, Yao Deng, Ya-Qin Chen, Chen Liang, Yu-Jie Jiang, Wang Zhao, Rong Xiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cardiac arrhythmias
whole-exome sequencing (WES)
single-cell transcriptomics
SPP1+ macrophage
immune dysregulation
extracellular matrix remodeling
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1611663/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items