Could there be an association between chronic brucellosis and endothelial damage?
Introduction: In this study, we examined the effects of Brucella infection on endothelial dysfunction. Flow-mediated dilatation (FMD) measurement is indicator of the endothelial function, and abnormal values indicating endothelial dysfunction are accepted as the first stage of atherosclerosis. Meth...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Journal of Infection in Developing Countries
2015-01-01
|
| Series: | Journal of Infection in Developing Countries |
| Subjects: | |
| Online Access: | https://jidc.org/index.php/journal/article/view/4345 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850147971315793920 |
|---|---|
| author | Turhan Togan Ozgur Ciftci Hale Turan Huseyin Narci Hakan Gullu Hande Arslan |
| author_facet | Turhan Togan Ozgur Ciftci Hale Turan Huseyin Narci Hakan Gullu Hande Arslan |
| author_sort | Turhan Togan |
| collection | DOAJ |
| description | Introduction: In this study, we examined the effects of Brucella infection on endothelial dysfunction. Flow-mediated dilatation (FMD) measurement is indicator of the endothelial function, and abnormal values indicating endothelial dysfunction are accepted as the first stage of atherosclerosis.
Methodology: Twenty-four patients who had been treated for acute brucellosis two years before, and who had had no relapses in the follow-up, were prospectively included in the study, along with 30 healthy individuals in the control group. Results: While the highly sensitive C-reactive protein (hs-CRP) value was 2.42 ± 1.45 in the patient group, it was 1.72 ± 0.61 in the control group (p = 0.025). While the FMD value was 3.50 ± 1.58 in the patient group, it was 5.88 ± 1.88 in the control group (p < 0.001). While the percentage increase in FMD was 9.88 ± 4.92 in the patient group, it was 17.49 ± 6.3 in the control group (p < 0.001). It was observed that FMD value, the percentage increase in FMD, and basal radius were correlated with hs-CRP (r = -0.644, p < 0.001; r = - 0.558, p = 0.002; r = 0.444, p = 0.018, respectively). The carotid artery intima media thickness (IMT) value was found to be 0.61 ± 0.17 in the patient group and 0.49 ± 0.12 in the control group (p = 0.004).
Conclusions: The abnormal FMD and IMT values observed in brucellosis patients might be an indicator of more frequent arterial dysfunction, increased cardiovascular risk, and atherosclerosis.
|
| format | Article |
| id | doaj-art-a56feeed37a34a1c926105ab5935dc02 |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-a56feeed37a34a1c926105ab5935dc022025-08-20T02:27:23ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802015-01-0190110.3855/jidc.4345Could there be an association between chronic brucellosis and endothelial damage?Turhan Togan0Ozgur Ciftci1Hale Turan2Huseyin Narci3Hakan Gullu4Hande Arslan5Faculty of Medicine, Baskent University, Ankara, TurkeyFaculty of Medicine, Baskent University, Ankara, TurkeyFaculty of Medicine, Baskent University, Ankara, TurkeyFaculty of Medicine, Baskent University, Ankara, TurkeyFaculty of Medicine, Baskent University, Ankara, TurkeyFaculty of Medicine, Baskent University, Ankara, TurkeyIntroduction: In this study, we examined the effects of Brucella infection on endothelial dysfunction. Flow-mediated dilatation (FMD) measurement is indicator of the endothelial function, and abnormal values indicating endothelial dysfunction are accepted as the first stage of atherosclerosis. Methodology: Twenty-four patients who had been treated for acute brucellosis two years before, and who had had no relapses in the follow-up, were prospectively included in the study, along with 30 healthy individuals in the control group. Results: While the highly sensitive C-reactive protein (hs-CRP) value was 2.42 ± 1.45 in the patient group, it was 1.72 ± 0.61 in the control group (p = 0.025). While the FMD value was 3.50 ± 1.58 in the patient group, it was 5.88 ± 1.88 in the control group (p < 0.001). While the percentage increase in FMD was 9.88 ± 4.92 in the patient group, it was 17.49 ± 6.3 in the control group (p < 0.001). It was observed that FMD value, the percentage increase in FMD, and basal radius were correlated with hs-CRP (r = -0.644, p < 0.001; r = - 0.558, p = 0.002; r = 0.444, p = 0.018, respectively). The carotid artery intima media thickness (IMT) value was found to be 0.61 ± 0.17 in the patient group and 0.49 ± 0.12 in the control group (p = 0.004). Conclusions: The abnormal FMD and IMT values observed in brucellosis patients might be an indicator of more frequent arterial dysfunction, increased cardiovascular risk, and atherosclerosis. https://jidc.org/index.php/journal/article/view/4345brucellosisatherosclerosisendothelial dysfunctionhs-CRP |
| spellingShingle | Turhan Togan Ozgur Ciftci Hale Turan Huseyin Narci Hakan Gullu Hande Arslan Could there be an association between chronic brucellosis and endothelial damage? Journal of Infection in Developing Countries brucellosis atherosclerosis endothelial dysfunction hs-CRP |
| title | Could there be an association between chronic brucellosis and endothelial damage? |
| title_full | Could there be an association between chronic brucellosis and endothelial damage? |
| title_fullStr | Could there be an association between chronic brucellosis and endothelial damage? |
| title_full_unstemmed | Could there be an association between chronic brucellosis and endothelial damage? |
| title_short | Could there be an association between chronic brucellosis and endothelial damage? |
| title_sort | could there be an association between chronic brucellosis and endothelial damage |
| topic | brucellosis atherosclerosis endothelial dysfunction hs-CRP |
| url | https://jidc.org/index.php/journal/article/view/4345 |
| work_keys_str_mv | AT turhantogan couldtherebeanassociationbetweenchronicbrucellosisandendothelialdamage AT ozgurciftci couldtherebeanassociationbetweenchronicbrucellosisandendothelialdamage AT haleturan couldtherebeanassociationbetweenchronicbrucellosisandendothelialdamage AT huseyinnarci couldtherebeanassociationbetweenchronicbrucellosisandendothelialdamage AT hakangullu couldtherebeanassociationbetweenchronicbrucellosisandendothelialdamage AT handearslan couldtherebeanassociationbetweenchronicbrucellosisandendothelialdamage |