Synthesis, Photophysics, and Potential Antifungal Activity of Benzo[<i>a</i>]phenoxazines
The synthesis and full characterization of new hydroxyl benzo[<i>a</i>]phenoxazinium chlorides with <i>N</i>-(di)propyl and/or <i>N</i>-isopropyl groups in the 5 and 9 positions are described. Photophysical studies carried out in ethanol and water revealed strong...
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| Format: | Article |
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MDPI AG
2024-11-01
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| Series: | Chemistry Proceedings |
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| Online Access: | https://www.mdpi.com/2673-4583/16/1/81 |
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| author | Bárbara S. G. Guimarães Maria João Sousa M. Sameiro T. Gonçalves |
| author_facet | Bárbara S. G. Guimarães Maria João Sousa M. Sameiro T. Gonçalves |
| author_sort | Bárbara S. G. Guimarães |
| collection | DOAJ |
| description | The synthesis and full characterization of new hydroxyl benzo[<i>a</i>]phenoxazinium chlorides with <i>N</i>-(di)propyl and/or <i>N</i>-isopropyl groups in the 5 and 9 positions are described. Photophysical studies carried out in ethanol and water revealed strong absorbances and significant fluorescence emissions at up to 676 nm. The antifungal activity was assessed against <i>Saccharomyces cerevisiae</i> and the results provide possible directions for further studies. |
| format | Article |
| id | doaj-art-a56dc136bd0b4fcd80c269739cf64eb5 |
| institution | Kabale University |
| issn | 2673-4583 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemistry Proceedings |
| spelling | doaj-art-a56dc136bd0b4fcd80c269739cf64eb52025-08-20T03:27:28ZengMDPI AGChemistry Proceedings2673-45832024-11-011618110.3390/ecsoc-28-20172Synthesis, Photophysics, and Potential Antifungal Activity of Benzo[<i>a</i>]phenoxazinesBárbara S. G. Guimarães0Maria João Sousa1M. Sameiro T. Gonçalves2Centre of Chemistry (CQUM), Department of Chemistry, University of Minho, Campus of Gualtar, 4710-057 Braga, PortugalCentre of Molecular and Environmental Biology (CBMA), Department of Biology, University of Minho, Campus of Gualtar, 4710-057 Braga, PortugalCentre of Chemistry (CQUM), Department of Chemistry, University of Minho, Campus of Gualtar, 4710-057 Braga, PortugalThe synthesis and full characterization of new hydroxyl benzo[<i>a</i>]phenoxazinium chlorides with <i>N</i>-(di)propyl and/or <i>N</i>-isopropyl groups in the 5 and 9 positions are described. Photophysical studies carried out in ethanol and water revealed strong absorbances and significant fluorescence emissions at up to 676 nm. The antifungal activity was assessed against <i>Saccharomyces cerevisiae</i> and the results provide possible directions for further studies.https://www.mdpi.com/2673-4583/16/1/81benzo[<i>a</i>]phenoxazinesNile Blue derivativesfluorescent probes<i>Saccharomyces cerevisiae</i> |
| spellingShingle | Bárbara S. G. Guimarães Maria João Sousa M. Sameiro T. Gonçalves Synthesis, Photophysics, and Potential Antifungal Activity of Benzo[<i>a</i>]phenoxazines Chemistry Proceedings benzo[<i>a</i>]phenoxazines Nile Blue derivatives fluorescent probes <i>Saccharomyces cerevisiae</i> |
| title | Synthesis, Photophysics, and Potential Antifungal Activity of Benzo[<i>a</i>]phenoxazines |
| title_full | Synthesis, Photophysics, and Potential Antifungal Activity of Benzo[<i>a</i>]phenoxazines |
| title_fullStr | Synthesis, Photophysics, and Potential Antifungal Activity of Benzo[<i>a</i>]phenoxazines |
| title_full_unstemmed | Synthesis, Photophysics, and Potential Antifungal Activity of Benzo[<i>a</i>]phenoxazines |
| title_short | Synthesis, Photophysics, and Potential Antifungal Activity of Benzo[<i>a</i>]phenoxazines |
| title_sort | synthesis photophysics and potential antifungal activity of benzo i a i phenoxazines |
| topic | benzo[<i>a</i>]phenoxazines Nile Blue derivatives fluorescent probes <i>Saccharomyces cerevisiae</i> |
| url | https://www.mdpi.com/2673-4583/16/1/81 |
| work_keys_str_mv | AT barbarasgguimaraes synthesisphotophysicsandpotentialantifungalactivityofbenzoiaiphenoxazines AT mariajoaosousa synthesisphotophysicsandpotentialantifungalactivityofbenzoiaiphenoxazines AT msameirotgoncalves synthesisphotophysicsandpotentialantifungalactivityofbenzoiaiphenoxazines |