Per- and polyfluoroalkyl substances are linked to incident primary dyslipidaemia: A prospective study from Chinese governmental employee cohort
This study aimed to explore the single and mixed effects of per- and polyfluoroalkyl substances (PFAS) on incident primary dyslipidaemia (PD). We further evaluated the interactions between PFAS and other environmental factors. After a 3-year follow-up of 11,843 government employees, 490 were newly d...
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Elsevier
2025-09-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325010012 |
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| author | Ling Li Feiyun Ouyang Jun He Chengcheng Zhang Yilu Li Dan Luo Shuiyuan Xiao |
| author_facet | Ling Li Feiyun Ouyang Jun He Chengcheng Zhang Yilu Li Dan Luo Shuiyuan Xiao |
| author_sort | Ling Li |
| collection | DOAJ |
| description | This study aimed to explore the single and mixed effects of per- and polyfluoroalkyl substances (PFAS) on incident primary dyslipidaemia (PD). We further evaluated the interactions between PFAS and other environmental factors. After a 3-year follow-up of 11,843 government employees, 490 were newly diagnosed with PD, and 490 healthy controls were matched based on age, sex, and study location. Six serum PFAS were detected using ultra-high-pressure liquid chromatography-tandem mass spectrometry. Individual air-pollutant exposure, demographic characteristics, lifestyles and other clinical indicators were obtained from environmental monitoring station data, questionnaires, laboratory, or physical examinations. Logistic regression was performed to analyse the single exposure of PFAS and the interactions. The weighted quantile sum (WQS) model was employed to assess the effect of PFAS mixtures. The serum perfluorooctane sulfonate (PFOS) was higher in PD group than in controls. Serum PFOS concentrations demonstrated monotonic increasing trend with PD incidence risk (OR = 1.33, 95 %CI: 1.01–1.74), and the risk of PD increased by 52 % in the high-concentration group (≥ 29.4 ng/mL) (OR = 1.52, 95 %CI: 1.01–2.30) than the low-concentration group. The WQS model demonstrated a 27 % increment in risk per quartile increase (OR = 1.27, 95 %CI: 1.00–1.62), with PFOS dominating the weight allocation (54.43 %). An antagonistic effect between serum PFOS exposure and aquatic product intake (Pinteraction = 0.009) was observed. Our findings revealed a PFAS mixture exposure on increased incident PD risks and identified PFOS > 29.4 ng/mL as a potentially hazardous substance while aquatic product intake seems to partially attenuate its risk. |
| format | Article |
| id | doaj-art-a56aa599ae254b9687a8ca607adc4bf4 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-a56aa599ae254b9687a8ca607adc4bf42025-08-20T03:41:04ZengElsevierEcotoxicology and Environmental Safety0147-65132025-09-0130211865610.1016/j.ecoenv.2025.118656Per- and polyfluoroalkyl substances are linked to incident primary dyslipidaemia: A prospective study from Chinese governmental employee cohortLing Li0Feiyun Ouyang1Jun He2Chengcheng Zhang3Yilu Li4Dan Luo5Shuiyuan Xiao6Clinical Epidemiology Research Office, Hunan Provincial People's Hospital, First Affiliated Hospital of Hunan Normal University, Changsha, China; Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, ChinaSchool of Computer & Information Sciences, University of Massachusetts Lowell, Lowell, MA, USADepartment of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USADepartment of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, ChinaDepartment of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, ChinaDepartment of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, ChinaDepartment of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, China; Department of Psychiatry, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Corresponding author at: Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, China.This study aimed to explore the single and mixed effects of per- and polyfluoroalkyl substances (PFAS) on incident primary dyslipidaemia (PD). We further evaluated the interactions between PFAS and other environmental factors. After a 3-year follow-up of 11,843 government employees, 490 were newly diagnosed with PD, and 490 healthy controls were matched based on age, sex, and study location. Six serum PFAS were detected using ultra-high-pressure liquid chromatography-tandem mass spectrometry. Individual air-pollutant exposure, demographic characteristics, lifestyles and other clinical indicators were obtained from environmental monitoring station data, questionnaires, laboratory, or physical examinations. Logistic regression was performed to analyse the single exposure of PFAS and the interactions. The weighted quantile sum (WQS) model was employed to assess the effect of PFAS mixtures. The serum perfluorooctane sulfonate (PFOS) was higher in PD group than in controls. Serum PFOS concentrations demonstrated monotonic increasing trend with PD incidence risk (OR = 1.33, 95 %CI: 1.01–1.74), and the risk of PD increased by 52 % in the high-concentration group (≥ 29.4 ng/mL) (OR = 1.52, 95 %CI: 1.01–2.30) than the low-concentration group. The WQS model demonstrated a 27 % increment in risk per quartile increase (OR = 1.27, 95 %CI: 1.00–1.62), with PFOS dominating the weight allocation (54.43 %). An antagonistic effect between serum PFOS exposure and aquatic product intake (Pinteraction = 0.009) was observed. Our findings revealed a PFAS mixture exposure on increased incident PD risks and identified PFOS > 29.4 ng/mL as a potentially hazardous substance while aquatic product intake seems to partially attenuate its risk.http://www.sciencedirect.com/science/article/pii/S0147651325010012Primary dyslipidaemiaPer- and polyfluoroalkyl substancesCohortNested case-control studyChinese governmental employee |
| spellingShingle | Ling Li Feiyun Ouyang Jun He Chengcheng Zhang Yilu Li Dan Luo Shuiyuan Xiao Per- and polyfluoroalkyl substances are linked to incident primary dyslipidaemia: A prospective study from Chinese governmental employee cohort Ecotoxicology and Environmental Safety Primary dyslipidaemia Per- and polyfluoroalkyl substances Cohort Nested case-control study Chinese governmental employee |
| title | Per- and polyfluoroalkyl substances are linked to incident primary dyslipidaemia: A prospective study from Chinese governmental employee cohort |
| title_full | Per- and polyfluoroalkyl substances are linked to incident primary dyslipidaemia: A prospective study from Chinese governmental employee cohort |
| title_fullStr | Per- and polyfluoroalkyl substances are linked to incident primary dyslipidaemia: A prospective study from Chinese governmental employee cohort |
| title_full_unstemmed | Per- and polyfluoroalkyl substances are linked to incident primary dyslipidaemia: A prospective study from Chinese governmental employee cohort |
| title_short | Per- and polyfluoroalkyl substances are linked to incident primary dyslipidaemia: A prospective study from Chinese governmental employee cohort |
| title_sort | per and polyfluoroalkyl substances are linked to incident primary dyslipidaemia a prospective study from chinese governmental employee cohort |
| topic | Primary dyslipidaemia Per- and polyfluoroalkyl substances Cohort Nested case-control study Chinese governmental employee |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325010012 |
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