Endoscopic resection for gastric subepithelial tumours: a retrospective cohort study
Objective Although endoscopic resection (ER) is an established technique for gastric subepithelial tumours (SETs), comprehensive data on its efficacy and safety remain limited. This study aimed to evaluate the efficacy and safety of ER in patients with gastric SETs and to identify risk factors assoc...
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2514788 |
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| author | Ji Li Dong Xu Weifeng Huang Xiaoyi Lei Yanqing Wang Jinyan Zhang |
| author_facet | Ji Li Dong Xu Weifeng Huang Xiaoyi Lei Yanqing Wang Jinyan Zhang |
| author_sort | Ji Li |
| collection | DOAJ |
| description | Objective Although endoscopic resection (ER) is an established technique for gastric subepithelial tumours (SETs), comprehensive data on its efficacy and safety remain limited. This study aimed to evaluate the efficacy and safety of ER in patients with gastric SETs and to identify risk factors associated with procedure-related complications.Materials and methods This retrospective study included 483 patients who underwent ER for gastric SETs between February 2012 and May 2023. Patient demographics, tumour characteristics, and clinical outcomes were evaluated. Multivariate analysis was performed to identify risk factors for complications.Results The median tumour size was 1.2 cm (range: 0.5–6.0 cm). The complete resection rate was 93.8%. Complications occurred in 6.8% of cases, including perioperative bleeding (2.1%), perforation (1.7%), and both (0.4%), with 0.8% of cases requiring conversion to surgery. Larger tumours notably increased the risks of incomplete resection (odds ratio [OR] = 1.605, 95% confidence interval [CI]: 1.066–2.416, p = 0.023), perioperative bleeding (OR = 2.004, 95% CI: 1.099–3.653, p = 0.023), and perforation (OR = 3.476, 95% CI: 1.830–6.602, p < 0.001). Additionally, an irregular tumour shape significantly elevated the risk of incomplete resection (OR = 10.771, 95% CI: 3.452–33.605, p < 0.001). Conversely, tumours located in the middle third (OR = 0.068, 95% CI: 0.014–0.341, p = 0.001) and the upper third (OR = 0.211, 95% CI: 0.051–0.884, p = 0.033) of the stomach substantially reduced the risk of incomplete resection.Conclusions ER is an effective and generally safe treatment modality for managing gastric SETs. However, larger tumour size and irregular shape are significant risk factors for adverse outcomes. |
| format | Article |
| id | doaj-art-a56a984c0c984d71a9d30e293788cc3f |
| institution | OA Journals |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
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| series | Annals of Medicine |
| spelling | doaj-art-a56a984c0c984d71a9d30e293788cc3f2025-08-20T02:06:31ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2514788Endoscopic resection for gastric subepithelial tumours: a retrospective cohort studyJi Li0Dong Xu1Weifeng Huang2Xiaoyi Lei3Yanqing Wang4Jinyan Zhang5Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Ultrasound, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaDepartment of Gastroenterology and Hepatology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, ChinaObjective Although endoscopic resection (ER) is an established technique for gastric subepithelial tumours (SETs), comprehensive data on its efficacy and safety remain limited. This study aimed to evaluate the efficacy and safety of ER in patients with gastric SETs and to identify risk factors associated with procedure-related complications.Materials and methods This retrospective study included 483 patients who underwent ER for gastric SETs between February 2012 and May 2023. Patient demographics, tumour characteristics, and clinical outcomes were evaluated. Multivariate analysis was performed to identify risk factors for complications.Results The median tumour size was 1.2 cm (range: 0.5–6.0 cm). The complete resection rate was 93.8%. Complications occurred in 6.8% of cases, including perioperative bleeding (2.1%), perforation (1.7%), and both (0.4%), with 0.8% of cases requiring conversion to surgery. Larger tumours notably increased the risks of incomplete resection (odds ratio [OR] = 1.605, 95% confidence interval [CI]: 1.066–2.416, p = 0.023), perioperative bleeding (OR = 2.004, 95% CI: 1.099–3.653, p = 0.023), and perforation (OR = 3.476, 95% CI: 1.830–6.602, p < 0.001). Additionally, an irregular tumour shape significantly elevated the risk of incomplete resection (OR = 10.771, 95% CI: 3.452–33.605, p < 0.001). Conversely, tumours located in the middle third (OR = 0.068, 95% CI: 0.014–0.341, p = 0.001) and the upper third (OR = 0.211, 95% CI: 0.051–0.884, p = 0.033) of the stomach substantially reduced the risk of incomplete resection.Conclusions ER is an effective and generally safe treatment modality for managing gastric SETs. However, larger tumour size and irregular shape are significant risk factors for adverse outcomes.https://www.tandfonline.com/doi/10.1080/07853890.2025.2514788Endoscopic resectionsubepithelial tumoursefficacysafetyadverse outcomes |
| spellingShingle | Ji Li Dong Xu Weifeng Huang Xiaoyi Lei Yanqing Wang Jinyan Zhang Endoscopic resection for gastric subepithelial tumours: a retrospective cohort study Annals of Medicine Endoscopic resection subepithelial tumours efficacy safety adverse outcomes |
| title | Endoscopic resection for gastric subepithelial tumours: a retrospective cohort study |
| title_full | Endoscopic resection for gastric subepithelial tumours: a retrospective cohort study |
| title_fullStr | Endoscopic resection for gastric subepithelial tumours: a retrospective cohort study |
| title_full_unstemmed | Endoscopic resection for gastric subepithelial tumours: a retrospective cohort study |
| title_short | Endoscopic resection for gastric subepithelial tumours: a retrospective cohort study |
| title_sort | endoscopic resection for gastric subepithelial tumours a retrospective cohort study |
| topic | Endoscopic resection subepithelial tumours efficacy safety adverse outcomes |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2514788 |
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