Inflammatory myopathies: an update for neurologists
ABSTRACT Idiopathic inflammatory myopathies (IIM) are a heterogenous group of treatable myopathies. Patients present mainly to the rheumatologist and neurologists, complaining of acute or subacute onset of proximal weakness. Extramuscular manifestations may occur, including involvement of the lungs,...
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Thieme Revinter Publicações
2022-08-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000700238&tlng=en |
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| author | André Macedo Serafim Silva Eliene Dutra Campos Edmar Zanoteli |
| author_facet | André Macedo Serafim Silva Eliene Dutra Campos Edmar Zanoteli |
| author_sort | André Macedo Serafim Silva |
| collection | DOAJ |
| description | ABSTRACT Idiopathic inflammatory myopathies (IIM) are a heterogenous group of treatable myopathies. Patients present mainly to the rheumatologist and neurologists, complaining of acute or subacute onset of proximal weakness. Extramuscular manifestations may occur, including involvement of the lungs, skin, and joints. Classically, the diagnosis used to be made based on the creatine kinase level increase, abnormalities in electroneuromyography and presence of inflammatory infiltrates in the muscle biopsy. Recently, the importance of autoantibodies has increased, and now they may be identified in more than half of IIM patients. The continuous clinicoseropathological improvement in IIM knowledge has changed the way we see these patients and how we classify them. In the past, only polymyositis, dermatomyositis and inclusion body myopathy were described. Currently, immune-mediated necrotizing myopathy, overlap myositis and antisynthetase syndrome have been considered the most common forms of IIM in clinical practice, increasing the spectrum of classification. Patients previously considered to have polymyositis, in fact have these other forms of seropositive IIM. In this article, we reviewed the new concepts of classification, a practical way to make the diagnosis and how to plan the treatment of patients suffering from IIM. |
| format | Article |
| id | doaj-art-a567c0cd78f94947a9047aa016ababe2 |
| institution | DOAJ |
| issn | 1678-4227 |
| language | English |
| publishDate | 2022-08-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-a567c0cd78f94947a9047aa016ababe22025-08-20T03:19:00ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272022-08-01805 suppl 123824810.1590/0004-282x-anp-2022-s131Inflammatory myopathies: an update for neurologistsAndré Macedo Serafim Silvahttps://orcid.org/0000-0002-5792-5878Eliene Dutra Camposhttps://orcid.org/0000-0002-6167-2105Edmar Zanotelihttps://orcid.org/0000-0002-4991-6760ABSTRACT Idiopathic inflammatory myopathies (IIM) are a heterogenous group of treatable myopathies. Patients present mainly to the rheumatologist and neurologists, complaining of acute or subacute onset of proximal weakness. Extramuscular manifestations may occur, including involvement of the lungs, skin, and joints. Classically, the diagnosis used to be made based on the creatine kinase level increase, abnormalities in electroneuromyography and presence of inflammatory infiltrates in the muscle biopsy. Recently, the importance of autoantibodies has increased, and now they may be identified in more than half of IIM patients. The continuous clinicoseropathological improvement in IIM knowledge has changed the way we see these patients and how we classify them. In the past, only polymyositis, dermatomyositis and inclusion body myopathy were described. Currently, immune-mediated necrotizing myopathy, overlap myositis and antisynthetase syndrome have been considered the most common forms of IIM in clinical practice, increasing the spectrum of classification. Patients previously considered to have polymyositis, in fact have these other forms of seropositive IIM. In this article, we reviewed the new concepts of classification, a practical way to make the diagnosis and how to plan the treatment of patients suffering from IIM.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000700238&tlng=enMyositisDermatomyositisPolymyositisImmune-Mediated Necrotizing Myopathy |
| spellingShingle | André Macedo Serafim Silva Eliene Dutra Campos Edmar Zanoteli Inflammatory myopathies: an update for neurologists Arquivos de Neuro-Psiquiatria Myositis Dermatomyositis Polymyositis Immune-Mediated Necrotizing Myopathy |
| title | Inflammatory myopathies: an update for neurologists |
| title_full | Inflammatory myopathies: an update for neurologists |
| title_fullStr | Inflammatory myopathies: an update for neurologists |
| title_full_unstemmed | Inflammatory myopathies: an update for neurologists |
| title_short | Inflammatory myopathies: an update for neurologists |
| title_sort | inflammatory myopathies an update for neurologists |
| topic | Myositis Dermatomyositis Polymyositis Immune-Mediated Necrotizing Myopathy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2022000700238&tlng=en |
| work_keys_str_mv | AT andremacedoserafimsilva inflammatorymyopathiesanupdateforneurologists AT elienedutracampos inflammatorymyopathiesanupdateforneurologists AT edmarzanoteli inflammatorymyopathiesanupdateforneurologists |