Clinical significance of very high IgE levels (≥1000 IU/mL): Population-based study of 118,211 adults
Background: Very high serum IgE (≥1000 IU/mL) is reported in atopic disorders. However, data on its significance in nonallergic disorders are limited. Objective: We aimed to analyze the diagnostic value of very high IgE in adults. Methods: A retrospective nationwide study was conducted using the ele...
Saved in:
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-05-01
|
| Series: | Journal of Allergy and Clinical Immunology: Global |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772829325000049 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849323425778106368 |
|---|---|
| author | Shay Nemet, MD Daniel Elbirt, MD Ramon Cohen, MD Keren Mahlab-Guri, MD Shira Bezalel-Rosenberg, MD Ilan Asher, MD Aviv Talmon, MD Limor Rubin, MD Yaarit Ribak, MD Ruslan Sergienko, MHA Udi Nussinovitch, MD, PhD Yuval Tal, MD, PhD Oded Shamriz, MD |
| author_facet | Shay Nemet, MD Daniel Elbirt, MD Ramon Cohen, MD Keren Mahlab-Guri, MD Shira Bezalel-Rosenberg, MD Ilan Asher, MD Aviv Talmon, MD Limor Rubin, MD Yaarit Ribak, MD Ruslan Sergienko, MHA Udi Nussinovitch, MD, PhD Yuval Tal, MD, PhD Oded Shamriz, MD |
| author_sort | Shay Nemet, MD |
| collection | DOAJ |
| description | Background: Very high serum IgE (≥1000 IU/mL) is reported in atopic disorders. However, data on its significance in nonallergic disorders are limited. Objective: We aimed to analyze the diagnostic value of very high IgE in adults. Methods: A retrospective nationwide study was conducted using the electronic database of Clalit Health Services, covering adults (≥18 years) treated between 2002 and 2022. Subjects with IgE ≥ 1000 IU/mL were compared to the controls with IgE < 100 IU/mL across 3 age groups (18-30, 31-64, and ≥65 years). Outcomes included eosinophilic, autoimmune, autoinflammatory, and cardiovascular disorders (CVD), cancer, and inborn errors of immunity (IEI). A multivariable Cox regression model determined statistical significance (P < .05). Results: The study included 118,211 subjects: 110,116 controls and 8635 with very high IgE levels. Excluding insect sting and drug allergies, very high IgE was more common across all tested allergic disorders, with asthma showing the highest rate (64.49%). Univariable analysis showed higher prevalence of CVD (3.88% vs 2.72%, P < .001), eosinophilic disorders (0.42% vs 0.06%, P < .001), and IEI (0.35% vs 0.20%, P = .004) in the very high IgE group. Multivariable analysis revealed age-dependent significant results: higher CVD risk in ages 31-64 (hazard ratio = 1.249; 95% confidence interval, 1.054-1.481; P = .010) and borderline IEI association in ages 18-30 (hazard ratio = 1.802; 95% confidence interval, 0.978-3.321; P = .059). Risk of eosinophilic disorders was increased across all age groups (P < .001). Conclusions: Very high IgE level of ≥1000 IU/mL is associated with increased risks of CVD, IEI, and eosinophilic disorders. Physicians should consider further assessment for these conditions in nonallergic patients with very high IgE levels. |
| format | Article |
| id | doaj-art-a5663e8183be45cab0f22cf4f281f362 |
| institution | Kabale University |
| issn | 2772-8293 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Allergy and Clinical Immunology: Global |
| spelling | doaj-art-a5663e8183be45cab0f22cf4f281f3622025-08-20T03:49:03ZengElsevierJournal of Allergy and Clinical Immunology: Global2772-82932025-05-014210040310.1016/j.jacig.2025.100403Clinical significance of very high IgE levels (≥1000 IU/mL): Population-based study of 118,211 adultsShay Nemet, MD0Daniel Elbirt, MD1Ramon Cohen, MD2Keren Mahlab-Guri, MD3Shira Bezalel-Rosenberg, MD4Ilan Asher, MD5Aviv Talmon, MD6Limor Rubin, MD7Yaarit Ribak, MD8Ruslan Sergienko, MHA9Udi Nussinovitch, MD, PhD10Yuval Tal, MD, PhD11Oded Shamriz, MD12Allergy and Clinical Immunology Unit, Kaplan Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelAllergy and Clinical Immunology Unit, Kaplan Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelAllergy and Clinical Immunology Unit, Kaplan Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelAllergy and Clinical Immunology Unit, Kaplan Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelAllergy and Clinical Immunology Unit, Kaplan Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelAllergy and Clinical Immunology Unit, Kaplan Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelAllergy and Clinical Immunology Unit, Department of Medicine, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelAllergy and Clinical Immunology Unit, Department of Medicine, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelAllergy and Clinical Immunology Unit, Department of Medicine, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelDepartment of Health Policy and Management, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, IsraelDepartment of Cardiology, Edith Wolfson Medical Center, Holon, Israel; Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelAllergy and Clinical Immunology Unit, Department of Medicine, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, IsraelAllergy and Clinical Immunology Unit, Department of Medicine, Hadassah Medical Organization, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel; Corresponding author: Oded Shamriz, MD, Allergy and Clinical Immunology Unit, Hadassah Medical Organization, Jerusalem, Israel.Background: Very high serum IgE (≥1000 IU/mL) is reported in atopic disorders. However, data on its significance in nonallergic disorders are limited. Objective: We aimed to analyze the diagnostic value of very high IgE in adults. Methods: A retrospective nationwide study was conducted using the electronic database of Clalit Health Services, covering adults (≥18 years) treated between 2002 and 2022. Subjects with IgE ≥ 1000 IU/mL were compared to the controls with IgE < 100 IU/mL across 3 age groups (18-30, 31-64, and ≥65 years). Outcomes included eosinophilic, autoimmune, autoinflammatory, and cardiovascular disorders (CVD), cancer, and inborn errors of immunity (IEI). A multivariable Cox regression model determined statistical significance (P < .05). Results: The study included 118,211 subjects: 110,116 controls and 8635 with very high IgE levels. Excluding insect sting and drug allergies, very high IgE was more common across all tested allergic disorders, with asthma showing the highest rate (64.49%). Univariable analysis showed higher prevalence of CVD (3.88% vs 2.72%, P < .001), eosinophilic disorders (0.42% vs 0.06%, P < .001), and IEI (0.35% vs 0.20%, P = .004) in the very high IgE group. Multivariable analysis revealed age-dependent significant results: higher CVD risk in ages 31-64 (hazard ratio = 1.249; 95% confidence interval, 1.054-1.481; P = .010) and borderline IEI association in ages 18-30 (hazard ratio = 1.802; 95% confidence interval, 0.978-3.321; P = .059). Risk of eosinophilic disorders was increased across all age groups (P < .001). Conclusions: Very high IgE level of ≥1000 IU/mL is associated with increased risks of CVD, IEI, and eosinophilic disorders. Physicians should consider further assessment for these conditions in nonallergic patients with very high IgE levels.http://www.sciencedirect.com/science/article/pii/S2772829325000049IgEvery high IgEimmunoglobulin Epopulation-based study |
| spellingShingle | Shay Nemet, MD Daniel Elbirt, MD Ramon Cohen, MD Keren Mahlab-Guri, MD Shira Bezalel-Rosenberg, MD Ilan Asher, MD Aviv Talmon, MD Limor Rubin, MD Yaarit Ribak, MD Ruslan Sergienko, MHA Udi Nussinovitch, MD, PhD Yuval Tal, MD, PhD Oded Shamriz, MD Clinical significance of very high IgE levels (≥1000 IU/mL): Population-based study of 118,211 adults Journal of Allergy and Clinical Immunology: Global IgE very high IgE immunoglobulin E population-based study |
| title | Clinical significance of very high IgE levels (≥1000 IU/mL): Population-based study of 118,211 adults |
| title_full | Clinical significance of very high IgE levels (≥1000 IU/mL): Population-based study of 118,211 adults |
| title_fullStr | Clinical significance of very high IgE levels (≥1000 IU/mL): Population-based study of 118,211 adults |
| title_full_unstemmed | Clinical significance of very high IgE levels (≥1000 IU/mL): Population-based study of 118,211 adults |
| title_short | Clinical significance of very high IgE levels (≥1000 IU/mL): Population-based study of 118,211 adults |
| title_sort | clinical significance of very high ige levels ≥1000 iu ml population based study of 118 211 adults |
| topic | IgE very high IgE immunoglobulin E population-based study |
| url | http://www.sciencedirect.com/science/article/pii/S2772829325000049 |
| work_keys_str_mv | AT shaynemetmd clinicalsignificanceofveryhighigelevels1000iumlpopulationbasedstudyof118211adults AT danielelbirtmd clinicalsignificanceofveryhighigelevels1000iumlpopulationbasedstudyof118211adults AT ramoncohenmd clinicalsignificanceofveryhighigelevels1000iumlpopulationbasedstudyof118211adults AT kerenmahlabgurimd clinicalsignificanceofveryhighigelevels1000iumlpopulationbasedstudyof118211adults AT shirabezalelrosenbergmd clinicalsignificanceofveryhighigelevels1000iumlpopulationbasedstudyof118211adults AT ilanashermd clinicalsignificanceofveryhighigelevels1000iumlpopulationbasedstudyof118211adults AT avivtalmonmd clinicalsignificanceofveryhighigelevels1000iumlpopulationbasedstudyof118211adults AT limorrubinmd clinicalsignificanceofveryhighigelevels1000iumlpopulationbasedstudyof118211adults AT yaaritribakmd clinicalsignificanceofveryhighigelevels1000iumlpopulationbasedstudyof118211adults AT ruslansergienkomha clinicalsignificanceofveryhighigelevels1000iumlpopulationbasedstudyof118211adults AT udinussinovitchmdphd clinicalsignificanceofveryhighigelevels1000iumlpopulationbasedstudyof118211adults AT yuvaltalmdphd clinicalsignificanceofveryhighigelevels1000iumlpopulationbasedstudyof118211adults AT odedshamrizmd clinicalsignificanceofveryhighigelevels1000iumlpopulationbasedstudyof118211adults |