Alleviating effect of intranasal zinc on symptoms of allergic rhinitis
Background: There is no information about the clinical implications and kinetics of zinc (Zn) in the nasal cavity, a center of allergic inflammation, and serum in subjects with allergic rhinitis (AR). Objective: Effects of intranasal Zn on symptoms before and after allergen provocation were investig...
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Elsevier
2025-05-01
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| Series: | Journal of Allergy and Clinical Immunology: Global |
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| author | Huadong Xu, PhD Keming Tong, BS Naruhito Iwasaki, MD, PhD Nobutaka Ohgami, PhD Akira Tazaki, PhD Takumi Kagawa, MMSc Yanjun Gao, MMSc Delgama A.S.M. Nishadhi, MMSc Akihito Harusato, MD, PhD Masafumi Sakashita, MD, PhD Kazuhiro Ogi, MD, PhD Shigeharu Fujieda, MD, PhD Shogo Sumiya, MD Shinichi Iwasaki, MD, PhD Masashi Kato, MD, PhD |
| author_facet | Huadong Xu, PhD Keming Tong, BS Naruhito Iwasaki, MD, PhD Nobutaka Ohgami, PhD Akira Tazaki, PhD Takumi Kagawa, MMSc Yanjun Gao, MMSc Delgama A.S.M. Nishadhi, MMSc Akihito Harusato, MD, PhD Masafumi Sakashita, MD, PhD Kazuhiro Ogi, MD, PhD Shigeharu Fujieda, MD, PhD Shogo Sumiya, MD Shinichi Iwasaki, MD, PhD Masashi Kato, MD, PhD |
| author_sort | Huadong Xu, PhD |
| collection | DOAJ |
| description | Background: There is no information about the clinical implications and kinetics of zinc (Zn) in the nasal cavity, a center of allergic inflammation, and serum in subjects with allergic rhinitis (AR). Objective: Effects of intranasal Zn on symptoms before and after allergen provocation were investigated in humans and mice with or without AR. Methods: The first clinical follow-up study for Zn levels in nasal epithelial lining fluid (ELF) and serum was conducted in 57 control subjects and 44 patients with Japanese cedar pollinosis (JCP), a representative seasonal AR, from preseason to season. The clinical implications and kinetics of Zn levels in ELF and serum were further investigated in model mice with JCP. Results: This clinical study showed that the Zn level in nasal ELF from patients with JCP was increased after pollen exposure and became significantly higher than that in nasal ELF from controls in the JCP season. Conversely, the serum Zn level in patients was decreased after pollen exposure and became significantly lower than that in the controls in the JCP season. To further investigate the clinical implication of Zn level, model mice that mimicked the kinetics of intranasal and serum Zn levels as well as the symptoms in patients with JCP were established. The mouse interventional study showed that the symptoms of mice with provocative JCP were significantly improved by treatment with the putative human-equivalent dose of Zn. The relative number of mucin-secreting goblet cells, a sign of provocative allergic rhinitis, in the mice was decreased by intranasal treatment with Zn. Conclusion: The study’s behavioral and pathologic results indicate that an increased level of intranasal Zn can alleviate symptoms of AR. |
| format | Article |
| id | doaj-art-a5645502bd9d4755b716b601393804c7 |
| institution | Kabale University |
| issn | 2772-8293 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Allergy and Clinical Immunology: Global |
| spelling | doaj-art-a5645502bd9d4755b716b601393804c72025-02-02T05:29:35ZengElsevierJournal of Allergy and Clinical Immunology: Global2772-82932025-05-0142100408Alleviating effect of intranasal zinc on symptoms of allergic rhinitisHuadong Xu, PhD0Keming Tong, BS1Naruhito Iwasaki, MD, PhD2Nobutaka Ohgami, PhD3Akira Tazaki, PhD4Takumi Kagawa, MMSc5Yanjun Gao, MMSc6Delgama A.S.M. Nishadhi, MMSc7Akihito Harusato, MD, PhD8Masafumi Sakashita, MD, PhD9Kazuhiro Ogi, MD, PhD10Shigeharu Fujieda, MD, PhD11Shogo Sumiya, MD12Shinichi Iwasaki, MD, PhD13Masashi Kato, MD, PhD14Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan; Voluntary Body for International Healthcare in Universities, Nagoya, Japan; School of Public Health, Hangzhou Medical College, Hangzhou, ChinaDepartment of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan; Voluntary Body for International Healthcare in Universities, Nagoya, JapanDepartment of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan; Voluntary Body for International Healthcare in Universities, Nagoya, JapanDepartment of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan; Voluntary Body for International Healthcare in Universities, Nagoya, Japan; Department of Hygiene, Fujita Health University, Toyoake, JapanDepartment of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan; Voluntary Body for International Healthcare in Universities, Nagoya, JapanDepartment of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan; Voluntary Body for International Healthcare in Universities, Nagoya, JapanDepartment of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan; Voluntary Body for International Healthcare in Universities, Nagoya, JapanDepartment of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan; Voluntary Body for International Healthcare in Universities, Nagoya, JapanDepartment of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan; Voluntary Body for International Healthcare in Universities, Nagoya, JapanDivision of Otorhinolaryngology-Head and Neck Surgery, Department of Sensory and Locomotor Medicine, University of Fukui, Fukui, JapanDivision of Otorhinolaryngology-Head and Neck Surgery, Department of Sensory and Locomotor Medicine, University of Fukui, Fukui, JapanDivision of Otorhinolaryngology-Head and Neck Surgery, Department of Sensory and Locomotor Medicine, University of Fukui, Fukui, JapanDepartment of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan; Department of Otolaryngology-Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanDepartment of Otolaryngology-Head and Neck Surgery, Nagoya City University Graduate School of Medical Sciences, Nagoya, JapanDepartment of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan; Voluntary Body for International Healthcare in Universities, Nagoya, Japan; Corresponding author: Masashi Kato, MD, PhD, Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.Background: There is no information about the clinical implications and kinetics of zinc (Zn) in the nasal cavity, a center of allergic inflammation, and serum in subjects with allergic rhinitis (AR). Objective: Effects of intranasal Zn on symptoms before and after allergen provocation were investigated in humans and mice with or without AR. Methods: The first clinical follow-up study for Zn levels in nasal epithelial lining fluid (ELF) and serum was conducted in 57 control subjects and 44 patients with Japanese cedar pollinosis (JCP), a representative seasonal AR, from preseason to season. The clinical implications and kinetics of Zn levels in ELF and serum were further investigated in model mice with JCP. Results: This clinical study showed that the Zn level in nasal ELF from patients with JCP was increased after pollen exposure and became significantly higher than that in nasal ELF from controls in the JCP season. Conversely, the serum Zn level in patients was decreased after pollen exposure and became significantly lower than that in the controls in the JCP season. To further investigate the clinical implication of Zn level, model mice that mimicked the kinetics of intranasal and serum Zn levels as well as the symptoms in patients with JCP were established. The mouse interventional study showed that the symptoms of mice with provocative JCP were significantly improved by treatment with the putative human-equivalent dose of Zn. The relative number of mucin-secreting goblet cells, a sign of provocative allergic rhinitis, in the mice was decreased by intranasal treatment with Zn. Conclusion: The study’s behavioral and pathologic results indicate that an increased level of intranasal Zn can alleviate symptoms of AR.http://www.sciencedirect.com/science/article/pii/S2772829325000098Allergic rhinitiszincintranasal exposureJapanese cedar pollinosisnasal epithelial lining fluid |
| spellingShingle | Huadong Xu, PhD Keming Tong, BS Naruhito Iwasaki, MD, PhD Nobutaka Ohgami, PhD Akira Tazaki, PhD Takumi Kagawa, MMSc Yanjun Gao, MMSc Delgama A.S.M. Nishadhi, MMSc Akihito Harusato, MD, PhD Masafumi Sakashita, MD, PhD Kazuhiro Ogi, MD, PhD Shigeharu Fujieda, MD, PhD Shogo Sumiya, MD Shinichi Iwasaki, MD, PhD Masashi Kato, MD, PhD Alleviating effect of intranasal zinc on symptoms of allergic rhinitis Journal of Allergy and Clinical Immunology: Global Allergic rhinitis zinc intranasal exposure Japanese cedar pollinosis nasal epithelial lining fluid |
| title | Alleviating effect of intranasal zinc on symptoms of allergic rhinitis |
| title_full | Alleviating effect of intranasal zinc on symptoms of allergic rhinitis |
| title_fullStr | Alleviating effect of intranasal zinc on symptoms of allergic rhinitis |
| title_full_unstemmed | Alleviating effect of intranasal zinc on symptoms of allergic rhinitis |
| title_short | Alleviating effect of intranasal zinc on symptoms of allergic rhinitis |
| title_sort | alleviating effect of intranasal zinc on symptoms of allergic rhinitis |
| topic | Allergic rhinitis zinc intranasal exposure Japanese cedar pollinosis nasal epithelial lining fluid |
| url | http://www.sciencedirect.com/science/article/pii/S2772829325000098 |
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