Microbiological factors in osteoarthritis
Introduction Osteoarthritis (OA) is a common polyetiological disease of the musculoskeletal system, leading to disability. The condition can prevent a person from work, affect mental health, increasing mortality and affecting health care resources around the world as a current and future disease b...
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Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics
2025-02-01
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| Series: | Гений oртопедии |
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| author | Evgeny O. Peretsmanas Vadim V. Zar Yaroslav A. Rukin Anastasia A. Kazyulina Aziza D. Pakhlavonova |
| author_facet | Evgeny O. Peretsmanas Vadim V. Zar Yaroslav A. Rukin Anastasia A. Kazyulina Aziza D. Pakhlavonova |
| author_sort | Evgeny O. Peretsmanas |
| collection | DOAJ |
| description | Introduction Osteoarthritis (OA) is a common polyetiological disease of the musculoskeletal system, leading
to disability. The condition can prevent a person from work, affect mental health, increasing mortality
and affecting health care resources around the world as a current and future disease burden. OA had been
considered an aseptic disease in the past and now the microbiological factor is viewed as one of the significant
etiological aspects of the condition.
The objective was to summarize the literature data on the role of microorganisms in the etiology
and pathogenesis of osteoarthritis, including concomitant HIV infection.
Material and methods The original literature search (2010 to 2023) was conducted on key resources including
Scientific Electronic Library (www.elibrary.ru) and the National Library of Medicine (www.pubmed.org).
Literature searches included both Russian and English studies reporting the effect of microbiological factors
on the development of arthropathy.
Results and discussion New, more advanced microbiological diagnostic methods have been used. There has
been evidence of a variety of microorganisms including pathogenic and opportunistic pathogens in the absence
of clinical and radiological signs of arthritis. This changes ideas about the etiology and pathogenesis
of degenerative processes in the articular cartilage and necessitates a revision of treatment protocols for some
joint diseases. Multicenter comprehensive studies of the microbiome of joint formations, blood and intestines
are needed.
Conclusions The presence of pathogenic microflora in the joint structures is evident in a significant
number of observations. There is evidence of a local infectious process in the local cellular elements
of osteochondral tissue in patients with previously diagnosed aseptic osteoarthritis. Intestinal microbiomes
and the urogenital tract are most common sources of infection. A local influence of the immunodeficiency
virus on the development of osteonecrotic processes in joint formations can be suggested in HIV patients. |
| format | Article |
| id | doaj-art-a55f200d74514b22afe60e45be2d6ced |
| institution | DOAJ |
| issn | 1028-4427 2542-131X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Russian Ilizarov Scientific Center for Restorative Traumatology and Orthopaedics |
| record_format | Article |
| series | Гений oртопедии |
| spelling | doaj-art-a55f200d74514b22afe60e45be2d6ced2025-08-20T03:13:15ZengRussian Ilizarov Scientific Center for Restorative Traumatology and OrthopaedicsГений oртопедии1028-44272542-131X2025-02-0131112913610.18019/1028-4427-2025-31-1-129-136Microbiological factors in osteoarthritisEvgeny O. Peretsmanas0https://orcid.org/0000-0001-7140-3200Vadim V. Zar1https://orcid.org/0000-0002-4021-798XYaroslav A. Rukin2https://orcid.org/0000-0001-7355-8556Anastasia A. Kazyulina3https://orcid.org/0000-0003-3116-0616Aziza D. Pakhlavonova4https://orcid.org/0000-0003-3994-2620National Medical Research Center of Phthisiopulmonology and Infectious Diseases, Moscow, Russian FederationNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Moscow, Russian FederationNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Moscow, Russian FederationNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Moscow, Russian FederationNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Moscow, Russian FederationIntroduction Osteoarthritis (OA) is a common polyetiological disease of the musculoskeletal system, leading to disability. The condition can prevent a person from work, affect mental health, increasing mortality and affecting health care resources around the world as a current and future disease burden. OA had been considered an aseptic disease in the past and now the microbiological factor is viewed as one of the significant etiological aspects of the condition. The objective was to summarize the literature data on the role of microorganisms in the etiology and pathogenesis of osteoarthritis, including concomitant HIV infection. Material and methods The original literature search (2010 to 2023) was conducted on key resources including Scientific Electronic Library (www.elibrary.ru) and the National Library of Medicine (www.pubmed.org). Literature searches included both Russian and English studies reporting the effect of microbiological factors on the development of arthropathy. Results and discussion New, more advanced microbiological diagnostic methods have been used. There has been evidence of a variety of microorganisms including pathogenic and opportunistic pathogens in the absence of clinical and radiological signs of arthritis. This changes ideas about the etiology and pathogenesis of degenerative processes in the articular cartilage and necessitates a revision of treatment protocols for some joint diseases. Multicenter comprehensive studies of the microbiome of joint formations, blood and intestines are needed. Conclusions The presence of pathogenic microflora in the joint structures is evident in a significant number of observations. There is evidence of a local infectious process in the local cellular elements of osteochondral tissue in patients with previously diagnosed aseptic osteoarthritis. Intestinal microbiomes and the urogenital tract are most common sources of infection. A local influence of the immunodeficiency virus on the development of osteonecrotic processes in joint formations can be suggested in HIV patients.osteoarthritismicrobiomeosteonecrosishivaseptic necrosis |
| spellingShingle | Evgeny O. Peretsmanas Vadim V. Zar Yaroslav A. Rukin Anastasia A. Kazyulina Aziza D. Pakhlavonova Microbiological factors in osteoarthritis Гений oртопедии osteoarthritis microbiome osteonecrosis hiv aseptic necrosis |
| title | Microbiological factors in osteoarthritis |
| title_full | Microbiological factors in osteoarthritis |
| title_fullStr | Microbiological factors in osteoarthritis |
| title_full_unstemmed | Microbiological factors in osteoarthritis |
| title_short | Microbiological factors in osteoarthritis |
| title_sort | microbiological factors in osteoarthritis |
| topic | osteoarthritis microbiome osteonecrosis hiv aseptic necrosis |
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