Successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab: a case report
The study objective is to report a case of successful treatment of disseminated nasopharyngeal carcinoma with nivolumab.Materials and methods. A 22-year-old male patient was admitted to N.N. Blokhin National Medical Research Center of Oncology with a diagnosis of T3N3M1 stage IV nasopharyngeal carci...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2019-07-01
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| Series: | Опухоли головы и шеи |
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| Online Access: | https://ogsh.abvpress.ru/jour/article/view/411 |
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| author | Yu. M. Bychkov A. M. Mudunov I. M. Gelfand B. G. Pkheshkhova O. D. Ryzhova А. A. Akhundov V. Z. Dobrokhotova М. N. Narimanov |
| author_facet | Yu. M. Bychkov A. M. Mudunov I. M. Gelfand B. G. Pkheshkhova O. D. Ryzhova А. A. Akhundov V. Z. Dobrokhotova М. N. Narimanov |
| author_sort | Yu. M. Bychkov |
| collection | DOAJ |
| description | The study objective is to report a case of successful treatment of disseminated nasopharyngeal carcinoma with nivolumab.Materials and methods. A 22-year-old male patient was admitted to N.N. Blokhin National Medical Research Center of Oncology with a diagnosis of T3N3M1 stage IV nasopharyngeal carcinoma with bone metastasis. After a course of radical chemoradiotherapy, the patient was found to have cancer progression. Between September 2016 and July 2017, the patient received chemotherapy with 3 lines of drugs, but with no effect. We decided to initiate treatment with PD-1 inhibitors. The patient received nivolumab 3 mg/kg every 2 weeks between July 2017 and March 2018.Results. Positron emission tomography (September 2018) demonstrated no increased uptake of [18F]-fluorodeoxyglucose in earlier identified cancer foci. Since September 2018, the patient has been in persistent remission without any therapy.Conclusion. This case report demonstrates high efficacy of PD-1 inhibitors in the treatment of disseminated recurrent nasopharyngeal squamous cell carcinoma, resistant to standard radiotherapy and chemotherapy. |
| format | Article |
| id | doaj-art-a55d5e928eac49639e0e281da4fc0868 |
| institution | Kabale University |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| publishDate | 2019-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj-art-a55d5e928eac49639e0e281da4fc08682025-08-20T03:37:09ZrusABV-pressОпухоли головы и шеи2222-14682411-46342019-07-01929910410.17650/2222-1468-2019-9-2-99-104353Successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab: a case reportYu. M. Bychkov0A. M. Mudunov1I. M. Gelfand2B. G. Pkheshkhova3O. D. Ryzhova4А. A. Akhundov5V. Z. Dobrokhotova6М. N. Narimanov7Russian Scientific Center of Roentgenoradiology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaI.M. Sechenov First Moscow State Medical University, Ministry of Health of RussiaN.N. Blokhin National Medical Research Center of Oncology, Ministry of Health of RussiaThe study objective is to report a case of successful treatment of disseminated nasopharyngeal carcinoma with nivolumab.Materials and methods. A 22-year-old male patient was admitted to N.N. Blokhin National Medical Research Center of Oncology with a diagnosis of T3N3M1 stage IV nasopharyngeal carcinoma with bone metastasis. After a course of radical chemoradiotherapy, the patient was found to have cancer progression. Between September 2016 and July 2017, the patient received chemotherapy with 3 lines of drugs, but with no effect. We decided to initiate treatment with PD-1 inhibitors. The patient received nivolumab 3 mg/kg every 2 weeks between July 2017 and March 2018.Results. Positron emission tomography (September 2018) demonstrated no increased uptake of [18F]-fluorodeoxyglucose in earlier identified cancer foci. Since September 2018, the patient has been in persistent remission without any therapy.Conclusion. This case report demonstrates high efficacy of PD-1 inhibitors in the treatment of disseminated recurrent nasopharyngeal squamous cell carcinoma, resistant to standard radiotherapy and chemotherapy.https://ogsh.abvpress.ru/jour/article/view/411nasopharyngeal carcinomametastaseschemotherapynivolumab |
| spellingShingle | Yu. M. Bychkov A. M. Mudunov I. M. Gelfand B. G. Pkheshkhova O. D. Ryzhova А. A. Akhundov V. Z. Dobrokhotova М. N. Narimanov Successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab: a case report Опухоли головы и шеи nasopharyngeal carcinoma metastases chemotherapy nivolumab |
| title | Successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab: a case report |
| title_full | Successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab: a case report |
| title_fullStr | Successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab: a case report |
| title_full_unstemmed | Successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab: a case report |
| title_short | Successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab: a case report |
| title_sort | successful treatment of recurrent metastatic nasopharyngeal carcinoma with nivolumab a case report |
| topic | nasopharyngeal carcinoma metastases chemotherapy nivolumab |
| url | https://ogsh.abvpress.ru/jour/article/view/411 |
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