Synthesis, Spectral Characterization, and Thermal and Cytotoxicity Studies of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) Complexes of Schiff Base Derived from 5-Hydroxymethylfuran-2-carbaldehyde

Coordination compounds of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) ions were synthesized from the furan ligand [5-hydroxymethylfuran-2-yl-methyleneaminoquinolin-2-one] (H-MFMAQ) derived from the condensation of 5-hydroxymethylfuran-2-carbaldehyde and 1-aminoquinolin-2(1H)-one. El...

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Main Authors: Amani S. Alturiqi, Abdel-Nasser M. A. Alaghaz, Reda A. Ammar, Mohamed E. Zayed
Format: Article
Language:English
Published: Wiley 2018-01-01
Series:Journal of Chemistry
Online Access:http://dx.doi.org/10.1155/2018/5816906
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author Amani S. Alturiqi
Abdel-Nasser M. A. Alaghaz
Reda A. Ammar
Mohamed E. Zayed
author_facet Amani S. Alturiqi
Abdel-Nasser M. A. Alaghaz
Reda A. Ammar
Mohamed E. Zayed
author_sort Amani S. Alturiqi
collection DOAJ
description Coordination compounds of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) ions were synthesized from the furan ligand [5-hydroxymethylfuran-2-yl-methyleneaminoquinolin-2-one] (H-MFMAQ) derived from the condensation of 5-hydroxymethylfuran-2-carbaldehyde and 1-aminoquinolin-2(1H)-one. Elemental analytical data, IR, NMR (1H, 13C, and 15N), EPR, XRD, SEM, TEM, EDX, TGA, mass, molar conductance, magnetic moment, and UV-Visible spectra techniques were used to confirm the structure of the synthesized chelates. According to the data obtained, the composition of the 1 : 1 metal ions : furan Schiff base ligand was found to be [M(MFMAQ)Cl2] (M = Cr(III) and Ru(III)) and [M(MFMAQ)Cl(H2O)]·nH2O in which (M = Mn(II); n=1, Co(II); n=0, Ni(II); n=2, Cu(II); n=0 and Zn(II); n=2.5). The measurements of magnetic susceptibility, ligand field parameter, and reflectance spectra suggested an octahedral geometry for the complexes. Central metals ions and furan Schiff base coordinated via O3 and N donor sites which was observed from IR spectra. The cytotoxic activities of all inspected compounds were evaluated towards human breast (MCF-7) and lung cancer (A549) cell lines.
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institution Kabale University
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spelling doaj-art-a55ce127424548939b57923e6f9703282025-02-03T01:10:08ZengWileyJournal of Chemistry2090-90632090-90712018-01-01201810.1155/2018/58169065816906Synthesis, Spectral Characterization, and Thermal and Cytotoxicity Studies of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) Complexes of Schiff Base Derived from 5-Hydroxymethylfuran-2-carbaldehydeAmani S. Alturiqi0Abdel-Nasser M. A. Alaghaz1Reda A. Ammar2Mohamed E. Zayed3Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi ArabiaDepartment of Chemistry, Faculty of Science, Jazan University, Jazan, Saudi ArabiaDepartment of Chemistry, College of Sciences Al Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi ArabiaDepartment of Botany and Microbiology, Faculty of Science, King Saud University, Riyadh 11541, Saudi ArabiaCoordination compounds of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) ions were synthesized from the furan ligand [5-hydroxymethylfuran-2-yl-methyleneaminoquinolin-2-one] (H-MFMAQ) derived from the condensation of 5-hydroxymethylfuran-2-carbaldehyde and 1-aminoquinolin-2(1H)-one. Elemental analytical data, IR, NMR (1H, 13C, and 15N), EPR, XRD, SEM, TEM, EDX, TGA, mass, molar conductance, magnetic moment, and UV-Visible spectra techniques were used to confirm the structure of the synthesized chelates. According to the data obtained, the composition of the 1 : 1 metal ions : furan Schiff base ligand was found to be [M(MFMAQ)Cl2] (M = Cr(III) and Ru(III)) and [M(MFMAQ)Cl(H2O)]·nH2O in which (M = Mn(II); n=1, Co(II); n=0, Ni(II); n=2, Cu(II); n=0 and Zn(II); n=2.5). The measurements of magnetic susceptibility, ligand field parameter, and reflectance spectra suggested an octahedral geometry for the complexes. Central metals ions and furan Schiff base coordinated via O3 and N donor sites which was observed from IR spectra. The cytotoxic activities of all inspected compounds were evaluated towards human breast (MCF-7) and lung cancer (A549) cell lines.http://dx.doi.org/10.1155/2018/5816906
spellingShingle Amani S. Alturiqi
Abdel-Nasser M. A. Alaghaz
Reda A. Ammar
Mohamed E. Zayed
Synthesis, Spectral Characterization, and Thermal and Cytotoxicity Studies of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) Complexes of Schiff Base Derived from 5-Hydroxymethylfuran-2-carbaldehyde
Journal of Chemistry
title Synthesis, Spectral Characterization, and Thermal and Cytotoxicity Studies of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) Complexes of Schiff Base Derived from 5-Hydroxymethylfuran-2-carbaldehyde
title_full Synthesis, Spectral Characterization, and Thermal and Cytotoxicity Studies of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) Complexes of Schiff Base Derived from 5-Hydroxymethylfuran-2-carbaldehyde
title_fullStr Synthesis, Spectral Characterization, and Thermal and Cytotoxicity Studies of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) Complexes of Schiff Base Derived from 5-Hydroxymethylfuran-2-carbaldehyde
title_full_unstemmed Synthesis, Spectral Characterization, and Thermal and Cytotoxicity Studies of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) Complexes of Schiff Base Derived from 5-Hydroxymethylfuran-2-carbaldehyde
title_short Synthesis, Spectral Characterization, and Thermal and Cytotoxicity Studies of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) Complexes of Schiff Base Derived from 5-Hydroxymethylfuran-2-carbaldehyde
title_sort synthesis spectral characterization and thermal and cytotoxicity studies of cr iii ru iii mn ii co ii ni ii cu ii and zn ii complexes of schiff base derived from 5 hydroxymethylfuran 2 carbaldehyde
url http://dx.doi.org/10.1155/2018/5816906
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