Scalable preparation of furanosteroidal viridin, β-viridin and viridiol from Trichoderma virens

Scalable preparation of furanosteroidal viridin, β-viridin and viridiol from Trichoderma virens

Abstract Viridin and viridiol, along with wortmannin, metabolized by filamentous fungus Trichoderma virens, are identical furanosteroids with high-potent inhibitory activity towards phosphatidylinositol 3-kinase (PI3K) that associates the growth of tumor cells. Therefore, structure–activity relation...

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Bibliographic Details
Main Authors: Wen Zhang, Kazu Sunami, Shuo Liu, Desita Triana, Zetryana Puteri Tachrim, Rikuto Kikuchi, Tohru Taniguchi, Kenji Monde, Tsunayoshi Takehara, Da-Yang Zhou, Takeyuki Suzuki, Yasuyuki Hashidoko, Makoto Hashimoto, Yuta Murai
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Trichoderma virens
Viridin
Β-viridin
Viridiol
[U-13C]-viridin
[U-13C]-viridol
Online Access:https://doi.org/10.1038/s41598-025-87070-z
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