Disseminated histoplasmosis and hemophagocytic lymphohistiocytosis: A case report
Hemophagocytic lymphohistiocytosis (HLH) is an immune deregulatory disorder resulting in severe inflammation and potentially fatal complications involving the bone marrow, liver, or brain; HLH can be considered primary. Secondary HLH is often associated with a specific trigger, including infectious...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | IDCases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214250925000307 |
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| author | Ruth C. Angrand Lauren Telesca Muhammad Aslam |
| author_facet | Ruth C. Angrand Lauren Telesca Muhammad Aslam |
| author_sort | Ruth C. Angrand |
| collection | DOAJ |
| description | Hemophagocytic lymphohistiocytosis (HLH) is an immune deregulatory disorder resulting in severe inflammation and potentially fatal complications involving the bone marrow, liver, or brain; HLH can be considered primary. Secondary HLH is often associated with a specific trigger, including infectious trigger that could be bacterial, viral, fungal or parasitic. Histoplasmosis-associated HLH is a relatively rare but previously reported complication. This case report presents a patient with HLH caused by disseminated histoplasmosis who was treated with etoposide, rituximab, amphotericin B, and itraconazole. This case report aims to highlight the importance of keeping a broad differential for when patients present with fevers of unknown origin. |
| format | Article |
| id | doaj-art-a5537364cf2a4c54845e4850a30b515b |
| institution | Kabale University |
| issn | 2214-2509 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IDCases |
| spelling | doaj-art-a5537364cf2a4c54845e4850a30b515b2025-02-08T05:00:29ZengElsevierIDCases2214-25092025-01-0139e02175Disseminated histoplasmosis and hemophagocytic lymphohistiocytosis: A case reportRuth C. Angrand0Lauren Telesca1Muhammad Aslam2Department of Internal Medicine, Stony Brook University Hospital, Stony Brook, New York, USA; Correspondence to: Stony Brook University Medical Center, Health Sciences Center, 101 Nicolls Road, Stony Brook, New York 11794, USA.Renaissance School of Medicine, Stony Brook University Hospital, Stony Brook, New York, USADepartment of Internal Medicine, Stony Brook University Hospital, Stony Brook, New York, USAHemophagocytic lymphohistiocytosis (HLH) is an immune deregulatory disorder resulting in severe inflammation and potentially fatal complications involving the bone marrow, liver, or brain; HLH can be considered primary. Secondary HLH is often associated with a specific trigger, including infectious trigger that could be bacterial, viral, fungal or parasitic. Histoplasmosis-associated HLH is a relatively rare but previously reported complication. This case report presents a patient with HLH caused by disseminated histoplasmosis who was treated with etoposide, rituximab, amphotericin B, and itraconazole. This case report aims to highlight the importance of keeping a broad differential for when patients present with fevers of unknown origin.http://www.sciencedirect.com/science/article/pii/S2214250925000307Disseminated histoplasmosisHLHLymphohistiocytosis |
| spellingShingle | Ruth C. Angrand Lauren Telesca Muhammad Aslam Disseminated histoplasmosis and hemophagocytic lymphohistiocytosis: A case report IDCases Disseminated histoplasmosis HLH Lymphohistiocytosis |
| title | Disseminated histoplasmosis and hemophagocytic lymphohistiocytosis: A case report |
| title_full | Disseminated histoplasmosis and hemophagocytic lymphohistiocytosis: A case report |
| title_fullStr | Disseminated histoplasmosis and hemophagocytic lymphohistiocytosis: A case report |
| title_full_unstemmed | Disseminated histoplasmosis and hemophagocytic lymphohistiocytosis: A case report |
| title_short | Disseminated histoplasmosis and hemophagocytic lymphohistiocytosis: A case report |
| title_sort | disseminated histoplasmosis and hemophagocytic lymphohistiocytosis a case report |
| topic | Disseminated histoplasmosis HLH Lymphohistiocytosis |
| url | http://www.sciencedirect.com/science/article/pii/S2214250925000307 |
| work_keys_str_mv | AT ruthcangrand disseminatedhistoplasmosisandhemophagocyticlymphohistiocytosisacasereport AT laurentelesca disseminatedhistoplasmosisandhemophagocyticlymphohistiocytosisacasereport AT muhammadaslam disseminatedhistoplasmosisandhemophagocyticlymphohistiocytosisacasereport |