Disseminated histoplasmosis and hemophagocytic lymphohistiocytosis: A case report
Hemophagocytic lymphohistiocytosis (HLH) is an immune deregulatory disorder resulting in severe inflammation and potentially fatal complications involving the bone marrow, liver, or brain; HLH can be considered primary. Secondary HLH is often associated with a specific trigger, including infectious...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
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| Series: | IDCases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214250925000307 |
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| Summary: | Hemophagocytic lymphohistiocytosis (HLH) is an immune deregulatory disorder resulting in severe inflammation and potentially fatal complications involving the bone marrow, liver, or brain; HLH can be considered primary. Secondary HLH is often associated with a specific trigger, including infectious trigger that could be bacterial, viral, fungal or parasitic. Histoplasmosis-associated HLH is a relatively rare but previously reported complication. This case report presents a patient with HLH caused by disseminated histoplasmosis who was treated with etoposide, rituximab, amphotericin B, and itraconazole. This case report aims to highlight the importance of keeping a broad differential for when patients present with fevers of unknown origin. |
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| ISSN: | 2214-2509 |