Retrospective analysis of IMA ligation level effects on nodal dissection and anastomosis in colorectal cancer
Abstract This study compared the outcomes of high versus low inferior mesenteric artery (IMA) ligation in 380 patients undergoing surgery for rectal or sigmoid colon cancer, with intraoperative indocyanine green (ICG) fluorescence angiography used to assess anastomotic perfusion. The high ligation g...
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| Format: | Article |
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Nature Portfolio
2025-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-10944-9 |
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| author | Daqing Cheng Yunpeng Zhang Qunjun Lin Ming Xu Jue Wang Peng Sun Bo Han |
| author_facet | Daqing Cheng Yunpeng Zhang Qunjun Lin Ming Xu Jue Wang Peng Sun Bo Han |
| author_sort | Daqing Cheng |
| collection | DOAJ |
| description | Abstract This study compared the outcomes of high versus low inferior mesenteric artery (IMA) ligation in 380 patients undergoing surgery for rectal or sigmoid colon cancer, with intraoperative indocyanine green (ICG) fluorescence angiography used to assess anastomotic perfusion. The high ligation group demonstrated significantly greater lymph node yield (13 vs.12 p < 0.001) and was associated with more advanced T/N stages, while operative time was longer (218 ± 45 vs. 189 ± 38 min, p < 0.001). ICG navigation enabled objective blood supply evaluation, resulting in no ischemia-related anastomotic leaks and comparable overall complication rates (3.1% vs. 3.4%, p = 0.82). These findings highlight that high ligation improves oncologic resection completeness through extended lymphadenectomy, whereas ICG fluorescence technology enhances anastomotic safety by providing real-time perfusion assessment, offering a dual advantage in colorectal cancer surgery. |
| format | Article |
| id | doaj-art-a54f72dd58cf4ec18e8ab1aaa3d27ab1 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-a54f72dd58cf4ec18e8ab1aaa3d27ab12025-08-20T03:46:07ZengNature PortfolioScientific Reports2045-23222025-07-011511810.1038/s41598-025-10944-9Retrospective analysis of IMA ligation level effects on nodal dissection and anastomosis in colorectal cancerDaqing Cheng0Yunpeng Zhang1Qunjun Lin2Ming Xu3Jue Wang4Peng Sun5Bo Han6Department of General Surgery, Tongren Hospital, Shanghai Jiao Tong University School of MedicineDepartment of General Surgery, Tongren Hospital, Shanghai Jiao Tong University School of MedicineDepartment of General Surgery, Tongren Hospital, Shanghai Jiao Tong University School of MedicineDepartment of General Surgery, Tongren Hospital, Shanghai Jiao Tong University School of MedicineDepartment of General Surgery, Tongren Hospital, Shanghai Jiao Tong University School of MedicineDepartment of General Surgery, Tongren Hospital, Shanghai Jiao Tong University School of MedicineDepartment of General Surgery, Tongren Hospital, Shanghai Jiao Tong University School of MedicineAbstract This study compared the outcomes of high versus low inferior mesenteric artery (IMA) ligation in 380 patients undergoing surgery for rectal or sigmoid colon cancer, with intraoperative indocyanine green (ICG) fluorescence angiography used to assess anastomotic perfusion. The high ligation group demonstrated significantly greater lymph node yield (13 vs.12 p < 0.001) and was associated with more advanced T/N stages, while operative time was longer (218 ± 45 vs. 189 ± 38 min, p < 0.001). ICG navigation enabled objective blood supply evaluation, resulting in no ischemia-related anastomotic leaks and comparable overall complication rates (3.1% vs. 3.4%, p = 0.82). These findings highlight that high ligation improves oncologic resection completeness through extended lymphadenectomy, whereas ICG fluorescence technology enhances anastomotic safety by providing real-time perfusion assessment, offering a dual advantage in colorectal cancer surgery.https://doi.org/10.1038/s41598-025-10944-9 |
| spellingShingle | Daqing Cheng Yunpeng Zhang Qunjun Lin Ming Xu Jue Wang Peng Sun Bo Han Retrospective analysis of IMA ligation level effects on nodal dissection and anastomosis in colorectal cancer Scientific Reports |
| title | Retrospective analysis of IMA ligation level effects on nodal dissection and anastomosis in colorectal cancer |
| title_full | Retrospective analysis of IMA ligation level effects on nodal dissection and anastomosis in colorectal cancer |
| title_fullStr | Retrospective analysis of IMA ligation level effects on nodal dissection and anastomosis in colorectal cancer |
| title_full_unstemmed | Retrospective analysis of IMA ligation level effects on nodal dissection and anastomosis in colorectal cancer |
| title_short | Retrospective analysis of IMA ligation level effects on nodal dissection and anastomosis in colorectal cancer |
| title_sort | retrospective analysis of ima ligation level effects on nodal dissection and anastomosis in colorectal cancer |
| url | https://doi.org/10.1038/s41598-025-10944-9 |
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