A Seven-Year Retrospective Study on the Surveillance of Hepatitis B in Laos
Objective. Lao PDR is one of the most highly endemic countries for hepatitis B in Asia and the second country for liver cancer incidence. Therefore, the follow-up of infected individuals through predictive serological markers is of utmost importance to monitor the progression of the pathology and ta...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2018/9462475 |
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| author | Phimpha Paboriboune Thomas Vial François Chassagne Philavanh Sitbounlang Sengaloun Soundala Stéphane Bertani Davone Sengmanothong Francois-Xavier Babin Nicolas Steenkeste Paul Dény Pascal Pineau Eric Deharo |
| author_facet | Phimpha Paboriboune Thomas Vial François Chassagne Philavanh Sitbounlang Sengaloun Soundala Stéphane Bertani Davone Sengmanothong Francois-Xavier Babin Nicolas Steenkeste Paul Dény Pascal Pineau Eric Deharo |
| author_sort | Phimpha Paboriboune |
| collection | DOAJ |
| description | Objective. Lao PDR is one of the most highly endemic countries for hepatitis B in Asia and the second country for liver cancer incidence. Therefore, the follow-up of infected individuals through predictive serological markers is of utmost importance to monitor the progression of the pathology and take the decision on treatment. Methods. A retrospective-descriptive cohort study was conducted on 3,857 HBV-infected patients. Information about infection status (viral load, VL), liver function (aminotransferases), and treatments was recorded. Results. M/F sex ratio was 1.77 for a median age of 37. Patients under 37 displayed higher VL than older ones and men had higher VL than women. Initial VL ranged from <50 IU/mL to 2.5 1013 IU/mL. Median aminotransferase values were 45.5 U/L for ALAT and 44 U/L for ASAT, ranging from <8 to >2,000 U/L. Men had higher aminotransferase than women. Globally 20% of patients received treatment (mainly immunostimulant and reverse-transcriptase inhibitors); 11% had high levels of VL and liver enzymes, but only 2% of them were treated. Conclusion. Public health decisions should be taken urgently to rationalise vaccination and provide fair access to early diagnosis and treatment; otherwise the burden of HBV-associated diseases will be overwhelming for Laos in the near future. |
| format | Article |
| id | doaj-art-a54e6939c5e743a7800e922823086da9 |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-a54e6939c5e743a7800e922823086da92025-02-03T05:58:48ZengWileyInternational Journal of Hepatology2090-34482090-34562018-01-01201810.1155/2018/94624759462475A Seven-Year Retrospective Study on the Surveillance of Hepatitis B in LaosPhimpha Paboriboune0Thomas Vial1François Chassagne2Philavanh Sitbounlang3Sengaloun Soundala4Stéphane Bertani5Davone Sengmanothong6Francois-Xavier Babin7Nicolas Steenkeste8Paul Dény9Pascal Pineau10Eric Deharo11Centre d’Infectiologie Lao-Christophe Mérieux, Vientiane, LaosIRD, UPS, UMR 152 PHARMADEV, Université de Toulouse, Toulouse, FranceIRD, UPS, UMR 152 PHARMADEV, Université de Toulouse, Toulouse, FranceCentre d’Infectiologie Lao-Christophe Mérieux, Vientiane, LaosCentre d’Infectiologie Lao-Christophe Mérieux, Vientiane, LaosIRD, UPS, UMR 152 PHARMADEV, Université de Toulouse, Toulouse, FranceCentre d’Infectiologie Lao-Christophe Mérieux, Vientiane, LaosFondation Mérieux, Lyon, FranceFondation Mérieux, Lyon, FranceHôpitaux Universitaires Paris Seine Saint Denis, Université Paris 13, Sorbonne Paris Cité, Paris, FranceInstitut Pasteur, Organisation Nucléaire et Oncogenèse, Paris, FranceIRD, UPS, UMR 152 PHARMADEV, Université de Toulouse, Toulouse, FranceObjective. Lao PDR is one of the most highly endemic countries for hepatitis B in Asia and the second country for liver cancer incidence. Therefore, the follow-up of infected individuals through predictive serological markers is of utmost importance to monitor the progression of the pathology and take the decision on treatment. Methods. A retrospective-descriptive cohort study was conducted on 3,857 HBV-infected patients. Information about infection status (viral load, VL), liver function (aminotransferases), and treatments was recorded. Results. M/F sex ratio was 1.77 for a median age of 37. Patients under 37 displayed higher VL than older ones and men had higher VL than women. Initial VL ranged from <50 IU/mL to 2.5 1013 IU/mL. Median aminotransferase values were 45.5 U/L for ALAT and 44 U/L for ASAT, ranging from <8 to >2,000 U/L. Men had higher aminotransferase than women. Globally 20% of patients received treatment (mainly immunostimulant and reverse-transcriptase inhibitors); 11% had high levels of VL and liver enzymes, but only 2% of them were treated. Conclusion. Public health decisions should be taken urgently to rationalise vaccination and provide fair access to early diagnosis and treatment; otherwise the burden of HBV-associated diseases will be overwhelming for Laos in the near future.http://dx.doi.org/10.1155/2018/9462475 |
| spellingShingle | Phimpha Paboriboune Thomas Vial François Chassagne Philavanh Sitbounlang Sengaloun Soundala Stéphane Bertani Davone Sengmanothong Francois-Xavier Babin Nicolas Steenkeste Paul Dény Pascal Pineau Eric Deharo A Seven-Year Retrospective Study on the Surveillance of Hepatitis B in Laos International Journal of Hepatology |
| title | A Seven-Year Retrospective Study on the Surveillance of Hepatitis B in Laos |
| title_full | A Seven-Year Retrospective Study on the Surveillance of Hepatitis B in Laos |
| title_fullStr | A Seven-Year Retrospective Study on the Surveillance of Hepatitis B in Laos |
| title_full_unstemmed | A Seven-Year Retrospective Study on the Surveillance of Hepatitis B in Laos |
| title_short | A Seven-Year Retrospective Study on the Surveillance of Hepatitis B in Laos |
| title_sort | seven year retrospective study on the surveillance of hepatitis b in laos |
| url | http://dx.doi.org/10.1155/2018/9462475 |
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