The mechanotransducer Piezo1 coordinates metabolism and inflammation to promote skin growth

The mechanotransducer Piezo1 coordinates metabolism and inflammation to promote skin growth

Abstract The skin has a remarkable ability to grow under constant stretch. Using a controlled tissue expansion system in mice, we identified an enhanced inflammatory-metabolic network in stretched skin via single-cell RNA sequencing, flow cytometry and spatial transcriptomics. Stretched epidermal ce...

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Bibliographic Details
Main Authors: Yingchao Xue, Elizabeth Winnicki, Zhaoxu Zhang, Ines Lopez, Saifeng Wang, Charles Kirby, Sam S. Lee, Ang Li, Chaewon Lee, Hana Minsky, Kaitlin Williams, Kevin Yueh-Hsun Yang, Ling He, Sashank K. Reddy, Luis A. Garza
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62270-3
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