Clinical Significance of Various Pathogens Identified in Patients Experiencing Acute Exacerbations of COPD: A Multi-center Study in South Korea
Background Respiratory infections play a major role in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This study assessed the prevalence of bacterial and viral pathogens and their clinical impact on patients with AECOPD. Methods This retrospective study included 1,186 patients...
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The Korean Academy of Tuberculosis and Respiratory Diseases
2025-04-01
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| Series: | Tuberculosis and Respiratory Diseases |
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| Online Access: | http://e-trd.org/upload/pdf/trd-2024-0089.pdf |
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| author | Hyun Woo Ji Soojoung Yu Yun Su Sim Hyewon Seo Jeong-Woong Park Kyung Hoon Min Deog Kyeom Kim Hyun Woo Lee Chin Kook Rhee Yong Bum Park Kyeong-Cheol Shin Kwang Ha Yoo Ji Ye Jung |
| author_facet | Hyun Woo Ji Soojoung Yu Yun Su Sim Hyewon Seo Jeong-Woong Park Kyung Hoon Min Deog Kyeom Kim Hyun Woo Lee Chin Kook Rhee Yong Bum Park Kyeong-Cheol Shin Kwang Ha Yoo Ji Ye Jung |
| author_sort | Hyun Woo Ji |
| collection | DOAJ |
| description | Background Respiratory infections play a major role in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This study assessed the prevalence of bacterial and viral pathogens and their clinical impact on patients with AECOPD. Methods This retrospective study included 1,186 patients diagnosed with AECOPD at 28 hospitals in South Korea between 2015 and 2018. We evaluated the identification rates of pathogens, basic patient characteristics, clinical features, and the factors associated with infections by potentially drug-resistant (PDR) pathogens using various microbiological tests. Results Bacteria, viruses, and both were detected in 262 (22.1%), 265 (22.5%), and 129 (10.9%) of patients, respectively. The most common pathogens included Pseudomonas aeruginosa (17.8%), Mycoplasma pneumoniae (11.2%), Streptococcus pneumoniae (9.0%), influenza A virus (19.0%), rhinovirus (15.8%), and respiratory syncytial virus (6.4%). Notably, a history of pulmonary tuberculosis (odds ratio [OR], 1.66; p=0.046), bronchiectasis (OR, 1.99; p=0.032), and the use of a triple inhaler regimen within the past 6 months (OR, 2.04; p=0.005) were identified as significant factors associated with infection by PDR pathogens. Moreover, patients infected with PDR pathogens exhibited extended hospital stays (15.9 days vs. 12.4 days, p=0.018) and higher intensive care unit admission rates (15.9% vs. 9.5%, p=0.030). Conclusion This study demonstrates that a variety of pathogens are involved in episodes of AECOPD. Nevertheless, additional research is required to confirm their role in the onset and progression of AECOPD. |
| format | Article |
| id | doaj-art-a544d1da2ec647d29e5ea949d670558e |
| institution | OA Journals |
| issn | 1738-3536 2005-6184 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | The Korean Academy of Tuberculosis and Respiratory Diseases |
| record_format | Article |
| series | Tuberculosis and Respiratory Diseases |
| spelling | doaj-art-a544d1da2ec647d29e5ea949d670558e2025-08-20T01:54:15ZengThe Korean Academy of Tuberculosis and Respiratory DiseasesTuberculosis and Respiratory Diseases1738-35362005-61842025-04-0188229230210.4046/trd.2024.00894912Clinical Significance of Various Pathogens Identified in Patients Experiencing Acute Exacerbations of COPD: A Multi-center Study in South KoreaHyun Woo Ji0Soojoung Yu1Yun Su Sim2Hyewon Seo3Jeong-Woong Park4Kyung Hoon Min5Deog Kyeom Kim6Hyun Woo Lee7Chin Kook Rhee8Yong Bum Park9Kyeong-Cheol Shin10Kwang Ha Yoo11Ji Ye Jung12 Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea International Healthcare Center, Soonchunhyang University Seoul Hospital, Seoul, Republic of Korea Division of Pulmonary, Allergy and Critical Care Medicine, Hallym University Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Republic of Korea Department of Internal Medicine, Kyungpook National University Hospital, School of Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Republic of Korea Division of Pulmonology, Allergy and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul National University College of Medicine, Seoul, Republic of Korea Department of Internal Medicine, Seoul St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Republic of Korea Division of Pulmonology and Allergy, Department of Internal Medicine, Yeungnam University Medical Center, Yeungnam University College of Medicine, Daegu, Republic of Korea Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Republic of Korea Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of KoreaBackground Respiratory infections play a major role in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This study assessed the prevalence of bacterial and viral pathogens and their clinical impact on patients with AECOPD. Methods This retrospective study included 1,186 patients diagnosed with AECOPD at 28 hospitals in South Korea between 2015 and 2018. We evaluated the identification rates of pathogens, basic patient characteristics, clinical features, and the factors associated with infections by potentially drug-resistant (PDR) pathogens using various microbiological tests. Results Bacteria, viruses, and both were detected in 262 (22.1%), 265 (22.5%), and 129 (10.9%) of patients, respectively. The most common pathogens included Pseudomonas aeruginosa (17.8%), Mycoplasma pneumoniae (11.2%), Streptococcus pneumoniae (9.0%), influenza A virus (19.0%), rhinovirus (15.8%), and respiratory syncytial virus (6.4%). Notably, a history of pulmonary tuberculosis (odds ratio [OR], 1.66; p=0.046), bronchiectasis (OR, 1.99; p=0.032), and the use of a triple inhaler regimen within the past 6 months (OR, 2.04; p=0.005) were identified as significant factors associated with infection by PDR pathogens. Moreover, patients infected with PDR pathogens exhibited extended hospital stays (15.9 days vs. 12.4 days, p=0.018) and higher intensive care unit admission rates (15.9% vs. 9.5%, p=0.030). Conclusion This study demonstrates that a variety of pathogens are involved in episodes of AECOPD. Nevertheless, additional research is required to confirm their role in the onset and progression of AECOPD.http://e-trd.org/upload/pdf/trd-2024-0089.pdfchronic obstructive pulmonary diseaseacute exacerbationpathogendrug resistance |
| spellingShingle | Hyun Woo Ji Soojoung Yu Yun Su Sim Hyewon Seo Jeong-Woong Park Kyung Hoon Min Deog Kyeom Kim Hyun Woo Lee Chin Kook Rhee Yong Bum Park Kyeong-Cheol Shin Kwang Ha Yoo Ji Ye Jung Clinical Significance of Various Pathogens Identified in Patients Experiencing Acute Exacerbations of COPD: A Multi-center Study in South Korea Tuberculosis and Respiratory Diseases chronic obstructive pulmonary disease acute exacerbation pathogen drug resistance |
| title | Clinical Significance of Various Pathogens Identified in Patients Experiencing Acute Exacerbations of COPD: A Multi-center Study in South Korea |
| title_full | Clinical Significance of Various Pathogens Identified in Patients Experiencing Acute Exacerbations of COPD: A Multi-center Study in South Korea |
| title_fullStr | Clinical Significance of Various Pathogens Identified in Patients Experiencing Acute Exacerbations of COPD: A Multi-center Study in South Korea |
| title_full_unstemmed | Clinical Significance of Various Pathogens Identified in Patients Experiencing Acute Exacerbations of COPD: A Multi-center Study in South Korea |
| title_short | Clinical Significance of Various Pathogens Identified in Patients Experiencing Acute Exacerbations of COPD: A Multi-center Study in South Korea |
| title_sort | clinical significance of various pathogens identified in patients experiencing acute exacerbations of copd a multi center study in south korea |
| topic | chronic obstructive pulmonary disease acute exacerbation pathogen drug resistance |
| url | http://e-trd.org/upload/pdf/trd-2024-0089.pdf |
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