Pattern of Expression of CDX2 in Colorectal Cancer and its Role in Prognosis: An Ambispective Observational Study
Introduction Caudal-type homeobox 2 (CDX2), a nuclear protein, is essential for the proliferation and development of intestinal epithelial cells and is frequently downregulated during tumorigenesis. CDX2 inhibits cell growth as well as stimulates differentiation by activating intestinal s...
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| Series: | Indian Journal of Medical and Paediatric Oncology |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1750207 |
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| author | Jagdeep Singh N G. Rajesh Biswajit Dubashi Nanda K. Maroju Prasanth Ganesan Kiran K. Matta I Charles Smita Kayal |
| author_facet | Jagdeep Singh N G. Rajesh Biswajit Dubashi Nanda K. Maroju Prasanth Ganesan Kiran K. Matta I Charles Smita Kayal |
| author_sort | Jagdeep Singh |
| collection | DOAJ |
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Introduction Caudal-type homeobox 2 (CDX2), a nuclear protein, is essential for the proliferation and development of intestinal epithelial cells and is frequently downregulated during tumorigenesis. CDX2 inhibits cell growth as well as stimulates differentiation by activating intestinal specific genes, thus lack of CDX2 favors tumor growth and aggressiveness. |
| format | Article |
| id | doaj-art-a54296a4342f438fac4b3ffeecad79a4 |
| institution | OA Journals |
| issn | 0971-5851 0975-2129 |
| language | English |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-a54296a4342f438fac4b3ffeecad79a42025-08-20T02:22:34ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-212910.1055/s-0042-1750207Pattern of Expression of CDX2 in Colorectal Cancer and its Role in Prognosis: An Ambispective Observational StudyJagdeep Singh0N G. Rajesh1Biswajit Dubashi2Nanda K. Maroju3Prasanth Ganesan4Kiran K. Matta5I Charles6Smita Kayal7https://orcid.org/0000-0001-7275-7377Department of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, IndiaDepartment of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, IndiaDepartment of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, IndiaDepartment of General Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, IndiaDepartment of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, IndiaDepartment of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, IndiaDepartment of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, IndiaDepartment of Medical Oncology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India Introduction Caudal-type homeobox 2 (CDX2), a nuclear protein, is essential for the proliferation and development of intestinal epithelial cells and is frequently downregulated during tumorigenesis. CDX2 inhibits cell growth as well as stimulates differentiation by activating intestinal specific genes, thus lack of CDX2 favors tumor growth and aggressiveness.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1750207colorectal cancerCDX2patternsurvivalprognosis |
| spellingShingle | Jagdeep Singh N G. Rajesh Biswajit Dubashi Nanda K. Maroju Prasanth Ganesan Kiran K. Matta I Charles Smita Kayal Pattern of Expression of CDX2 in Colorectal Cancer and its Role in Prognosis: An Ambispective Observational Study Indian Journal of Medical and Paediatric Oncology colorectal cancer CDX2 pattern survival prognosis |
| title | Pattern of Expression of CDX2 in Colorectal Cancer and its Role in Prognosis: An Ambispective Observational Study |
| title_full | Pattern of Expression of CDX2 in Colorectal Cancer and its Role in Prognosis: An Ambispective Observational Study |
| title_fullStr | Pattern of Expression of CDX2 in Colorectal Cancer and its Role in Prognosis: An Ambispective Observational Study |
| title_full_unstemmed | Pattern of Expression of CDX2 in Colorectal Cancer and its Role in Prognosis: An Ambispective Observational Study |
| title_short | Pattern of Expression of CDX2 in Colorectal Cancer and its Role in Prognosis: An Ambispective Observational Study |
| title_sort | pattern of expression of cdx2 in colorectal cancer and its role in prognosis an ambispective observational study |
| topic | colorectal cancer CDX2 pattern survival prognosis |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1750207 |
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