Depression and depressive symptoms among people living with vitiligo: findings from the cross-sectional, population-based global VALIANT survey
Purpose Vitiligo often affects quality of life and psychosocial well-being. This analysis of the population-based global Vitiligo and Life Impact Among International Communities (VALIANT) study sought to understand the impact of vitiligo on depression and depressive symptoms from the patient perspec...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Journal of Dermatological Treatment |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/09546634.2025.2504082 |
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| author | Khaled Ezzedine Davinder Parsad John E. Harris Nanja van Geel Jackie Gardner Kristen Bibeau Jessy Gao Haobo Ren Iltefat H. Hamzavi |
| author_facet | Khaled Ezzedine Davinder Parsad John E. Harris Nanja van Geel Jackie Gardner Kristen Bibeau Jessy Gao Haobo Ren Iltefat H. Hamzavi |
| author_sort | Khaled Ezzedine |
| collection | DOAJ |
| description | Purpose Vitiligo often affects quality of life and psychosocial well-being. This analysis of the population-based global Vitiligo and Life Impact Among International Communities (VALIANT) study sought to understand the impact of vitiligo on depression and depressive symptoms from the patient perspective.Materials and methods The cross-sectional survey collected information on patient demographics, clinical characteristics, mental health diagnoses, and depressive symptoms (assessed using the Patient Health Questionnaire–Depression screener [PHQ-9]) among recruited patients who reported a vitiligo diagnosis.Results Of 3541 VALIANT respondents, 24.5% reported formal diagnosis of depression, and 55.0% reported moderate-to-severe symptoms of depression per the PHQ-9. Rates of formally diagnosed depression and moderate-to-severe depressive symptoms were significantly higher in younger patients, those with Fitzpatrick skin types IV–VI (i.e. darker skin), >5% affected body surface area, hand or face involvement, and those receiving mental healthcare versus their counterparts (all p < 0.0001). Interestingly, moderate-to-severe depressive symptoms were more common among patients with shorter disease duration (≤2 vs 3–9 and ≥10 years; p < 0.01), but there was no correlation between diagnosed depression and disease duration.Conclusions These VALIANT study findings highlight that depression may be common but often undiagnosed among patients with vitiligo, reinforcing the importance of an improved and multifaceted approach to vitiligo management. |
| format | Article |
| id | doaj-art-a53f4ded933d4e538bb6cf7c13e6a4b4 |
| institution | DOAJ |
| issn | 0954-6634 1471-1753 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Dermatological Treatment |
| spelling | doaj-art-a53f4ded933d4e538bb6cf7c13e6a4b42025-08-20T03:07:50ZengTaylor & Francis GroupJournal of Dermatological Treatment0954-66341471-17532025-12-0136110.1080/09546634.2025.2504082Depression and depressive symptoms among people living with vitiligo: findings from the cross-sectional, population-based global VALIANT surveyKhaled Ezzedine0Davinder Parsad1John E. Harris2Nanja van Geel3Jackie Gardner4Kristen Bibeau5Jessy Gao6Haobo Ren7Iltefat H. Hamzavi8Department of Dermatology, Henri Mondor University Hospital and Université Paris-Est Créteil Val de Marne, Paris, FranceDepartment of Dermatology, Post Graduate Institute of Medical Education and Research, Chandigarh, IndiaDepartment of Dermatology, University of Massachusetts Chan Medical School, Worcester, MA, USADepartment of Dermatology, Ghent University Hospital, Ghent, BelgiumVitiligo Support International, Lynchburg, VA, USAIncyte Corporation, Wilmington, DE, USAIncyte Corporation, Wilmington, DE, USAIncyte Corporation, Wilmington, DE, USADepartment of Dermatology, Henry Ford Medical Center, Detroit, MI, USAPurpose Vitiligo often affects quality of life and psychosocial well-being. This analysis of the population-based global Vitiligo and Life Impact Among International Communities (VALIANT) study sought to understand the impact of vitiligo on depression and depressive symptoms from the patient perspective.Materials and methods The cross-sectional survey collected information on patient demographics, clinical characteristics, mental health diagnoses, and depressive symptoms (assessed using the Patient Health Questionnaire–Depression screener [PHQ-9]) among recruited patients who reported a vitiligo diagnosis.Results Of 3541 VALIANT respondents, 24.5% reported formal diagnosis of depression, and 55.0% reported moderate-to-severe symptoms of depression per the PHQ-9. Rates of formally diagnosed depression and moderate-to-severe depressive symptoms were significantly higher in younger patients, those with Fitzpatrick skin types IV–VI (i.e. darker skin), >5% affected body surface area, hand or face involvement, and those receiving mental healthcare versus their counterparts (all p < 0.0001). Interestingly, moderate-to-severe depressive symptoms were more common among patients with shorter disease duration (≤2 vs 3–9 and ≥10 years; p < 0.01), but there was no correlation between diagnosed depression and disease duration.Conclusions These VALIANT study findings highlight that depression may be common but often undiagnosed among patients with vitiligo, reinforcing the importance of an improved and multifaceted approach to vitiligo management.https://www.tandfonline.com/doi/10.1080/09546634.2025.2504082Depressiondisease burdenquality of lifesurveysymptomsvitiligo |
| spellingShingle | Khaled Ezzedine Davinder Parsad John E. Harris Nanja van Geel Jackie Gardner Kristen Bibeau Jessy Gao Haobo Ren Iltefat H. Hamzavi Depression and depressive symptoms among people living with vitiligo: findings from the cross-sectional, population-based global VALIANT survey Journal of Dermatological Treatment Depression disease burden quality of life survey symptoms vitiligo |
| title | Depression and depressive symptoms among people living with vitiligo: findings from the cross-sectional, population-based global VALIANT survey |
| title_full | Depression and depressive symptoms among people living with vitiligo: findings from the cross-sectional, population-based global VALIANT survey |
| title_fullStr | Depression and depressive symptoms among people living with vitiligo: findings from the cross-sectional, population-based global VALIANT survey |
| title_full_unstemmed | Depression and depressive symptoms among people living with vitiligo: findings from the cross-sectional, population-based global VALIANT survey |
| title_short | Depression and depressive symptoms among people living with vitiligo: findings from the cross-sectional, population-based global VALIANT survey |
| title_sort | depression and depressive symptoms among people living with vitiligo findings from the cross sectional population based global valiant survey |
| topic | Depression disease burden quality of life survey symptoms vitiligo |
| url | https://www.tandfonline.com/doi/10.1080/09546634.2025.2504082 |
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