Impact of Toceranib/Piroxicam/Cyclophosphamide Maintenance Therapy on Outcome of Dogs with Appendicular Osteosarcoma following Amputation and Carboplatin Chemotherapy: A Multi-Institutional Study.

Impact of Toceranib/Piroxicam/Cyclophosphamide Maintenance Therapy on Outcome of Dogs with Appendicular Osteosarcoma following Amputation and Carboplatin Chemotherapy: A Multi-Institutional Study.

<h4>Background</h4>We hypothesized that the addition of toceranib to metronomic cyclophosphamide/piroxicam therapy would significantly improve disease-free interval (DFI) and overall survival (OS) in dogs with appendicular osteosarcoma (OSA) following amputation and carboplatin chemother...

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Main Authors: Cheryl A London, Heather L Gardner, Tamra Mathie, Nicole Stingle, Roberta Portela, Michael L Pennell, Craig A Clifford, Mona P Rosenberg, David M Vail, Laurel E Williams, Kim L Cronin, Heather Wilson-Robles, Antonella Borgatti, Carolyn J Henry, Dennis B Bailey, Jennifer Locke, Nicole C Northrup, Martin Crawford-Jakubiak, Virginia L Gill, Mary K Klein, David M Ruslander, Doug H Thamm, Brenda Phillips, Gerald Post
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0124889&type=printable
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