Pathological complete response of locally advanced colon cancer after preoperative radiotherapy: a case report and narrative review of the literature
Abstract Background The oncological effectiveness of preoperative radiotherapy for locally advanced colon cancer is unclear. We report a case of pathological complete response in a patient with locally advanced ascending colon cancer after preoperative radiotherapy following failure of chemotherapy....
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Japan Surgical Society
2018-06-01
|
| Series: | Surgical Case Reports |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40792-018-0466-8 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849404163261202432 |
|---|---|
| author | Sho Sekiya Kiyotaka Imamura Shintaro Takeuchi Koichi Teramura Yusuke Watanabe Eiji Tamoto Minoru Takada Yoshihiro Kinoshita Yoshiyasu Anbo Fumitaka Nakamura Nobuichi Kashimura Hiroko Noguchi Katsutoshi Miura Satoshi Hirano |
| author_facet | Sho Sekiya Kiyotaka Imamura Shintaro Takeuchi Koichi Teramura Yusuke Watanabe Eiji Tamoto Minoru Takada Yoshihiro Kinoshita Yoshiyasu Anbo Fumitaka Nakamura Nobuichi Kashimura Hiroko Noguchi Katsutoshi Miura Satoshi Hirano |
| author_sort | Sho Sekiya |
| collection | DOAJ |
| description | Abstract Background The oncological effectiveness of preoperative radiotherapy for locally advanced colon cancer is unclear. We report a case of pathological complete response in a patient with locally advanced ascending colon cancer after preoperative radiotherapy following failure of chemotherapy. Case presentation A 65-year-old Japanese woman presented with malaise and hematochezia. A computed tomography (CT) revealed a tumor in the ascending colon which seemed to infiltrate the adjacent structures. She was diagnosed with locally advanced ascending colon cancer stages T4b, N2a, M0, and IIIC. We selected modified FOLFOX6 with panitumumab as neoadjuvant chemotherapy. However, we discontinued the chemotherapy after the 8th cycle because of disease progression and severe adverse effects. The patient then underwent radiotherapy of 60 Gy in 30 fractions, resulting in significant tumor size reduction. One month after the radiotherapy, we performed a right hemicolectomy with multivisceral resection without complications. Histopathologically, we found no residual cancer cells in the resected specimen. The patient remains alive and has not required additional therapies for 24 months, as there are no signs of recurrence. Conclusions The present case suggests that preoperative radiotherapy might be an effective treatment options for locally advanced colon cancer. |
| format | Article |
| id | doaj-art-a52b516b12cd4d2aa32591dc3281e940 |
| institution | Kabale University |
| issn | 2198-7793 |
| language | English |
| publishDate | 2018-06-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-a52b516b12cd4d2aa32591dc3281e9402025-08-20T03:37:05ZengJapan Surgical SocietySurgical Case Reports2198-77932018-06-01411510.1186/s40792-018-0466-8Pathological complete response of locally advanced colon cancer after preoperative radiotherapy: a case report and narrative review of the literatureSho Sekiya0Kiyotaka Imamura1Shintaro Takeuchi2Koichi Teramura3Yusuke Watanabe4Eiji Tamoto5Minoru Takada6Yoshihiro Kinoshita7Yoshiyasu Anbo8Fumitaka Nakamura9Nobuichi Kashimura10Hiroko Noguchi11Katsutoshi Miura12Satoshi Hirano13Department of Gastroenterological Surgery, Teine Keijinkai HospitalDepartment of Gastroenterological Surgery, Teine Keijinkai HospitalDepartment of Gastroenterological Surgery, Teine Keijinkai HospitalDepartment of Gastroenterological Surgery, Teine Keijinkai HospitalDepartment of Gastroenterological Surgery, Teine Keijinkai HospitalDepartment of Gastroenterological Surgery, Teine Keijinkai HospitalDepartment of Gastroenterological Surgery, Teine Keijinkai HospitalDepartment of Gastroenterological Surgery, Teine Keijinkai HospitalDepartment of Gastroenterological Surgery, Teine Keijinkai HospitalDepartment of Gastroenterological Surgery, Teine Keijinkai HospitalDepartment of Gastroenterological Surgery, Teine Keijinkai HospitalDepartment of Pathology, Teine Keijinkai HospitalDepartment of Radiology, Teine Keijinkai HospitalDepartment of Gastroenterological Surgery II, Hokkaido University Faculty of MedicineAbstract Background The oncological effectiveness of preoperative radiotherapy for locally advanced colon cancer is unclear. We report a case of pathological complete response in a patient with locally advanced ascending colon cancer after preoperative radiotherapy following failure of chemotherapy. Case presentation A 65-year-old Japanese woman presented with malaise and hematochezia. A computed tomography (CT) revealed a tumor in the ascending colon which seemed to infiltrate the adjacent structures. She was diagnosed with locally advanced ascending colon cancer stages T4b, N2a, M0, and IIIC. We selected modified FOLFOX6 with panitumumab as neoadjuvant chemotherapy. However, we discontinued the chemotherapy after the 8th cycle because of disease progression and severe adverse effects. The patient then underwent radiotherapy of 60 Gy in 30 fractions, resulting in significant tumor size reduction. One month after the radiotherapy, we performed a right hemicolectomy with multivisceral resection without complications. Histopathologically, we found no residual cancer cells in the resected specimen. The patient remains alive and has not required additional therapies for 24 months, as there are no signs of recurrence. Conclusions The present case suggests that preoperative radiotherapy might be an effective treatment options for locally advanced colon cancer.http://link.springer.com/article/10.1186/s40792-018-0466-8Colon cancerRadiotherapyPathological complete response |
| spellingShingle | Sho Sekiya Kiyotaka Imamura Shintaro Takeuchi Koichi Teramura Yusuke Watanabe Eiji Tamoto Minoru Takada Yoshihiro Kinoshita Yoshiyasu Anbo Fumitaka Nakamura Nobuichi Kashimura Hiroko Noguchi Katsutoshi Miura Satoshi Hirano Pathological complete response of locally advanced colon cancer after preoperative radiotherapy: a case report and narrative review of the literature Surgical Case Reports Colon cancer Radiotherapy Pathological complete response |
| title | Pathological complete response of locally advanced colon cancer after preoperative radiotherapy: a case report and narrative review of the literature |
| title_full | Pathological complete response of locally advanced colon cancer after preoperative radiotherapy: a case report and narrative review of the literature |
| title_fullStr | Pathological complete response of locally advanced colon cancer after preoperative radiotherapy: a case report and narrative review of the literature |
| title_full_unstemmed | Pathological complete response of locally advanced colon cancer after preoperative radiotherapy: a case report and narrative review of the literature |
| title_short | Pathological complete response of locally advanced colon cancer after preoperative radiotherapy: a case report and narrative review of the literature |
| title_sort | pathological complete response of locally advanced colon cancer after preoperative radiotherapy a case report and narrative review of the literature |
| topic | Colon cancer Radiotherapy Pathological complete response |
| url | http://link.springer.com/article/10.1186/s40792-018-0466-8 |
| work_keys_str_mv | AT shosekiya pathologicalcompleteresponseoflocallyadvancedcoloncancerafterpreoperativeradiotherapyacasereportandnarrativereviewoftheliterature AT kiyotakaimamura pathologicalcompleteresponseoflocallyadvancedcoloncancerafterpreoperativeradiotherapyacasereportandnarrativereviewoftheliterature AT shintarotakeuchi pathologicalcompleteresponseoflocallyadvancedcoloncancerafterpreoperativeradiotherapyacasereportandnarrativereviewoftheliterature AT koichiteramura pathologicalcompleteresponseoflocallyadvancedcoloncancerafterpreoperativeradiotherapyacasereportandnarrativereviewoftheliterature AT yusukewatanabe pathologicalcompleteresponseoflocallyadvancedcoloncancerafterpreoperativeradiotherapyacasereportandnarrativereviewoftheliterature AT eijitamoto pathologicalcompleteresponseoflocallyadvancedcoloncancerafterpreoperativeradiotherapyacasereportandnarrativereviewoftheliterature AT minorutakada pathologicalcompleteresponseoflocallyadvancedcoloncancerafterpreoperativeradiotherapyacasereportandnarrativereviewoftheliterature AT yoshihirokinoshita pathologicalcompleteresponseoflocallyadvancedcoloncancerafterpreoperativeradiotherapyacasereportandnarrativereviewoftheliterature AT yoshiyasuanbo pathologicalcompleteresponseoflocallyadvancedcoloncancerafterpreoperativeradiotherapyacasereportandnarrativereviewoftheliterature AT fumitakanakamura pathologicalcompleteresponseoflocallyadvancedcoloncancerafterpreoperativeradiotherapyacasereportandnarrativereviewoftheliterature AT nobuichikashimura pathologicalcompleteresponseoflocallyadvancedcoloncancerafterpreoperativeradiotherapyacasereportandnarrativereviewoftheliterature AT hirokonoguchi pathologicalcompleteresponseoflocallyadvancedcoloncancerafterpreoperativeradiotherapyacasereportandnarrativereviewoftheliterature AT katsutoshimiura pathologicalcompleteresponseoflocallyadvancedcoloncancerafterpreoperativeradiotherapyacasereportandnarrativereviewoftheliterature AT satoshihirano pathologicalcompleteresponseoflocallyadvancedcoloncancerafterpreoperativeradiotherapyacasereportandnarrativereviewoftheliterature |