EFFECT OF SIMVASTATIN THERAPY ON INDICATORS OF TRANSMITRAL BLOOD FLOW IN PATIENTS WITH DIASTOLIC HEART FAILURE
Aim. To study the effect of simvastatin added to standard therapy on the left ventricular structure functional status in patients with diastolic chronic heart failure (CHF).Material and methods. Patients (n=125) with diastolic CHF (relaxation disturbances and pseudonormalization) were included into...
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Столичная издательская компания
2015-09-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/276 |
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| author | T. V. Pinchuk Y. N. Fedulaev G. A. Khairetdinova A. A. Kozina V. N. Ryzhenkov N. M. Ahmedzhanov |
| author_facet | T. V. Pinchuk Y. N. Fedulaev G. A. Khairetdinova A. A. Kozina V. N. Ryzhenkov N. M. Ahmedzhanov |
| author_sort | T. V. Pinchuk |
| collection | DOAJ |
| description | Aim. To study the effect of simvastatin added to standard therapy on the left ventricular structure functional status in patients with diastolic chronic heart failure (CHF).Material and methods. Patients (n=125) with diastolic CHF (relaxation disturbances and pseudonormalization) were included into the open nonrandomized study. Patients of the main group (n=66) received simvastatin additionally to standard therapy of CHF. Patients of control group (n=59) received standard therapy only. Initially and after 6 months of treatment Doppler echocardiography (EchoCG) was performed with assessment of transmitral blood flow indices. On the basis of EchoCG data diastolic dysfunction types were determined in patients of the main group. Dynamics of EchoCG indices were evaluated in accordance with these types.Results. Significant increase in E (peak early diastolic left ventricular filling velocity) value by 14.1% (p<0.001) and E/A (where A - peak left ventricular filling velocity at atrial contraction) ratio by 18.7% (p<0.001) was found in the main group in estimating of transmitral flow indicators. Deceleration time of early diastolic filling significantly decreased by 7.8% (p<0.01). Other parameters did not change significantly both in the main and control groups. Intra-group comparison in the main group demonstrated that transmitral blood flow indices changed significantly only in patients with delayed relaxation (type I of diastolic dysfunction).Conclusion. Simvаstatin added to standard therapy of CHF resulted in significant improvement in the left ventricle diastolic function. |
| format | Article |
| id | doaj-art-a5279ef2ced247719567c4f2da7be631 |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2015-09-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-a5279ef2ced247719567c4f2da7be6312025-08-23T10:00:18ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532015-09-019665565910.20996/1819-6446-2013-9-6-655-659276EFFECT OF SIMVASTATIN THERAPY ON INDICATORS OF TRANSMITRAL BLOOD FLOW IN PATIENTS WITH DIASTOLIC HEART FAILURET. V. Pinchuk0Y. N. Fedulaev1G. A. Khairetdinova2A. A. Kozina3V. N. Ryzhenkov4N. M. Ahmedzhanov5Russian National Research Medical University named after N.I. Pirogov, MoscowRussian National Research Medical University named after N.I. Pirogov, MoscowCenter for Sport Innovative Technologies and Picked Teams Training of Moscow, MoscowMunicipal Clinical Hospital №13, MoscowMunicipal Clinical Hospital №13, MoscowState Research Center for Preventive Medicine, MoscowAim. To study the effect of simvastatin added to standard therapy on the left ventricular structure functional status in patients with diastolic chronic heart failure (CHF).Material and methods. Patients (n=125) with diastolic CHF (relaxation disturbances and pseudonormalization) were included into the open nonrandomized study. Patients of the main group (n=66) received simvastatin additionally to standard therapy of CHF. Patients of control group (n=59) received standard therapy only. Initially and after 6 months of treatment Doppler echocardiography (EchoCG) was performed with assessment of transmitral blood flow indices. On the basis of EchoCG data diastolic dysfunction types were determined in patients of the main group. Dynamics of EchoCG indices were evaluated in accordance with these types.Results. Significant increase in E (peak early diastolic left ventricular filling velocity) value by 14.1% (p<0.001) and E/A (where A - peak left ventricular filling velocity at atrial contraction) ratio by 18.7% (p<0.001) was found in the main group in estimating of transmitral flow indicators. Deceleration time of early diastolic filling significantly decreased by 7.8% (p<0.01). Other parameters did not change significantly both in the main and control groups. Intra-group comparison in the main group demonstrated that transmitral blood flow indices changed significantly only in patients with delayed relaxation (type I of diastolic dysfunction).Conclusion. Simvаstatin added to standard therapy of CHF resulted in significant improvement in the left ventricle diastolic function.https://www.rpcardio.online/jour/article/view/276left ventricle diastolic dysfunctionsimvastatinchronic heart failure |
| spellingShingle | T. V. Pinchuk Y. N. Fedulaev G. A. Khairetdinova A. A. Kozina V. N. Ryzhenkov N. M. Ahmedzhanov EFFECT OF SIMVASTATIN THERAPY ON INDICATORS OF TRANSMITRAL BLOOD FLOW IN PATIENTS WITH DIASTOLIC HEART FAILURE Рациональная фармакотерапия в кардиологии left ventricle diastolic dysfunction simvastatin chronic heart failure |
| title | EFFECT OF SIMVASTATIN THERAPY ON INDICATORS OF TRANSMITRAL BLOOD FLOW IN PATIENTS WITH DIASTOLIC HEART FAILURE |
| title_full | EFFECT OF SIMVASTATIN THERAPY ON INDICATORS OF TRANSMITRAL BLOOD FLOW IN PATIENTS WITH DIASTOLIC HEART FAILURE |
| title_fullStr | EFFECT OF SIMVASTATIN THERAPY ON INDICATORS OF TRANSMITRAL BLOOD FLOW IN PATIENTS WITH DIASTOLIC HEART FAILURE |
| title_full_unstemmed | EFFECT OF SIMVASTATIN THERAPY ON INDICATORS OF TRANSMITRAL BLOOD FLOW IN PATIENTS WITH DIASTOLIC HEART FAILURE |
| title_short | EFFECT OF SIMVASTATIN THERAPY ON INDICATORS OF TRANSMITRAL BLOOD FLOW IN PATIENTS WITH DIASTOLIC HEART FAILURE |
| title_sort | effect of simvastatin therapy on indicators of transmitral blood flow in patients with diastolic heart failure |
| topic | left ventricle diastolic dysfunction simvastatin chronic heart failure |
| url | https://www.rpcardio.online/jour/article/view/276 |
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